A5065118343- Photochromic and Fluorescence Chemistry
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Chemical Synthesis and Analysis
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Regulation of Appetite and Obesity
- Free Radicals and Antioxidants
- X-ray Diffraction in Crystallography
- Pharmacological Receptor Mechanisms and Effects
- Molecular Sensors and Ion Detection
- Circadian rhythm and melatonin
- Crystallization and Solubility Studies
- Adenosine and Purinergic Signaling
- Sleep and related disorders
- Tryptophan and brain disorders
University of Tsukuba
2021-2024
Tsukuba International University
2023-2024
Optochemistry, an emerging pharmacologic approach in which light is used to selectively activate or deactivate molecules, has the potential alleviate symptoms, cure diseases, and improve quality of life while preventing uncontrolled drug effects. The development in-vivo applications for optochemistry render brain cells photoresponsive without relying on genetic engineering been progressing slowly. nucleus accumbens (NAc) a region regulation slow-wave sleep (SWS) through integration...
Orexins are a family of neuropeptides that regulate various physiological events, such as sleep/wakefulness well emotional and feeding behavior, act on two G-protein-coupled receptors, i.e., orexin 1 (OX1R) 2 receptors (OX2R). Since the discovery dysfunction orexin/OX2R system causes sleep disorder narcolepsy, several OX2R-selective OX1/2R dual agonists have been disclosed. However, an OX1R-selective agonist has not yet reported, despite importance biological function OX1R. Herein, we report...
Background: Insomnia is associated with psychiatric illnesses such as bipolar disorder or schizophrenia. Treating insomnia improves psychotic symptoms severity, quality of life, and functional outcomes. Patients disorders are often dissatisfied the available therapeutic options for their insomnia. In contrast, positive allosteric modulation adenosine A 2A receptors (A Rs) leads to slow-wave sleep without cardiovascular side effects in contrast R agonists. Methods: We investigated hypnotic...
Structurally diverse small compounds are utilized to obtain hit that have suitable pharmacophores in appropriate three-dimensional conformations for the target drug receptors. We focused on 1,3,5-trioxazatriquinane skeleton, which has a high degree of properties, leading novel small-scale library based 1,3,5- trioxazatriquinane. In screening orexin receptor, some showed receptor antagonistic activity with rate 7%. By optimizing compounds, we discovered potent dual antagonist, 38b, and...
Orexins are a family of neuropeptides that regulate various physiological events such as sleep/wakefulness well emotional and feeding behavior, act on two G-protein-coupled receptors, i.e., the orexin 1 (OX1R) 2 receptors (OX2R). Since discovery dysfunction orexin/OX2R system causes sleep disorder narcolepsy, several OX2R-selective OX1/2R dual agonists have been disclosed. However, an OX1R-selective agonist has not yet reported, despite importance biological function OX1R. Herein, we report...
Structurally diverse small compounds are utilized to obtain hit that have suitable pharmacophores in appropriate three-dimensional conformations for the target drug receptors. We focused on 1,3,5-trioxazatriquinane skeleton, which has a high degree of properties, leading novel small-scale library based 1,3,5- trioxazatriquinane. In screening orexin receptor, some showed receptor antagonistic activity with rate 7%. By optimizing compounds, we discovered potent dual antagonist, 38b, and...