A5075296989- Mosquito-borne diseases and control
- Malaria Research and Control
- HIV Research and Treatment
- COVID-19 Clinical Research Studies
- Sinusitis and nasal conditions
- Infectious Diseases and Tuberculosis
- Anorectal Disease Treatments and Outcomes
- Phagocytosis and Immune Regulation
- Cell death mechanisms and regulation
- Computational Drug Discovery Methods
- Insect Pest Control Strategies
- Long-Term Effects of COVID-19
Chulalongkorn University
2022-2024
University of Da Nang
2023-2024
Da Nang University of Technology
2022
Abstract Flavone has recently been proved as a promising scaffold for the development of novel drug against dengue fever, one major health threats globally. However, structure–activity relationship study flavones on anti-dengue activity remains mostly limited to natural-occuring analogs. Herein, 27 flavone analogs were successfully synthesized, which 5 ( 5e , 5h 5o 5q and 5r ) novel. In total, 33 bearing diverse range substituents evaluated their efficacy DENV2-infected LLC/MK2 cells. The...
Dengue and Zika viruses are mosquito-borne flaviviruses burdening millions every year with hemorrhagic fever neurological symptoms. Baicalein was previously reported as a potential anti-flaviviral candidate halogenation of flavones flavanones potentiated their antiviral efficacies. Here, we that chemically modified 8-bromobaicalein effectively inhibited all dengue serotypes at 0.66-0.88 micromolar in cell-based system. The compound bound to serotype 2 conserved pocket the RdRp activity 6.93...
Background: The COVID-19 pandemic posed a significant healthcare crisis due to the emergence of acute respiratory infections, leading severe complications such as thrombosis. Meanwhile, D-dimer index serves dependable routine diagnostic marker for Therefore, it is hypothesized that could serve potential prognostic infection. Objective: To assess association between levels and severity among patients in Vietnamese central coastal region. Methods: A retrospective cross-sectional study was...
Chikungunya virus is a re-emerging arbovirus that has caused epidemic outbreaks in recent decades. Patients older age groups with high viral load and severe immunologic response during acute infection are likely to develop chronic arthritis joint pain. Currently, no antiviral drug available. Previous studies suggested flavone derivative, 8-bromobaicalein, was potential dengue Zika replication inhibitor cell-based system targeting flaviviral polymerase. Here we characterized 8-bromobaicalein...
Anti-SARS-CoV-2 and immunomodulatory drugs are important for treating clinically severe patients with respiratory distress symptoms. Alpha- gamma-mangostins (AM GM) were previously reported as potential 3C-like protease (3CL
Nghiên cứu được thực hiện trên 300 đối tượng là phụ nữ đến khám khoa tại Bệnh viện Đại học Y Hà Nội, qua thăm thể có ra khí hư bất thường và chỉ định làm xét nghiệm soi tươi dịch âm đạo tìm vi nấm. Tỷ lệ nhiễm nấm Candida sp. 22,3%. Một số yếu tố ảnh hưởng gồm: Nơi phơi quần lót thiếu ánh sáng (OR=3,871; 95%CI=1,204 – 12,447), nguồn nước sử dụng không phải sạch (OR=2,348; 95%CI=1,052 5,402), lượng bạn tình >1 (OR=2,795; 95%CI=1,094 7,139), tiền kháng sinh (OR=2,051; 95%CI=1,088 3,867),...