Abstract Background Individuals with glioma endorse high fear of cancer recurrence or progression (FCR), yet existing interventional studies for FCR exclude patients. Components interventions are not entirely translatable to those as they were designed non-CNS populations less risk recurrence, minimal-to-no neurologic sequelae, and different sources worry. Methods A two-stage Phase I ORBIT Model process was employed: Ia included consultation international experts two advisory boards toward...

Abstract Background The COVID-19 pandemic induced rapid adoption of telemedicine services for neuro-oncology patients at an increased risk infection. Neuropsychological assessment is important to care yet challenging complete outside a structured testing environment. Teleneuropsychology (TNP) has been explored in limited populations and proven feasible reliable. Conducting TNP visits directly patients’ home (DTH) had minimal prior study. Methods We used two voluntary surveys examine...

Abstract Objective: Neuropsychological assessment via video conferencing has been proposed during the COVID-19 pandemic. Existing literature demonstrated feasibility and acceptance of neuropsychological measures administered by videoconference, although few studies have examined patient TNP visits directly to patients’ homes (DTH-TNP). Methods: We modified a previously published satisfaction survey for DTH-TNP developed clinician examine experiences DTH-TNP. Results: Seventy-two patients...

Effective screening tools can help providers with treatment decisions, including when to refer patients for neuropsychological evaluations, which are the gold standard cognitive assessment of neurodegenerative disease. The authors examined whether performance on Addenbrooke's Cognitive Examination-Third Edition (ACE-III), a readily available tool older adults, predicted subsequent evaluations.In total, 217 referred neurocognitive concerns completed evaluation, ACE-III. Patients were...

Subjective cognitive function is an important outcome measure in oncology. The Functional Assessment of Cancer Therapy-Brain (FACT-Br) a quality life (QoL) that includes indices physical, emotional, social, and neurologic aspects disease but does not function. This study seeks to validate novel index cognition derived from the FACT-Br.Patients with heterogeneous cancer diagnoses (N = 214) completed neuropsychological evaluation self-report measures. Nine FACT-Br items regarding were combined...

Abstract Objective Patients with primary brain tumor (PBT) experience declines in cognitive functioning and frequently endorse sleep disturbance. Our single-arm proof-of-concept trial of Cognitive Behavioral Therapy for Insomnia (CBT-I) patients PBT demonstrated clinically significant improvements self-reported insomnia symptoms. The present study explored changes patients’ subjective objective following completion the six-week CBT-I intervention. Methods Participants clinical (N = 35; Mage...

Abstract Objective There is a connection between resilience and subjective cognitive symptoms in medical populations. However, there limited understanding of this relationship cancer survivors, no studies examine whether cognition may change from pre- to post-resilience training these patients. This study examined the function non-CNS survivors who participated resiliency intervention investigated potential influences cognition. Method Adult at Massachusetts General Hospital (N = 275, Mage...

Managing Cancer and Living Meaningfully (CALM) is a brief, evidence-based psychotherapy designed to help patients with advanced cancer cope the practical profound challenges of their illness. However, no study has systematically examined CALM in adults brain metastases, despite well-documented incidence distress this growing population. The primary aim trial was assess feasibility acceptability metastases. Patients metastases (N = 13) elevated symptoms depression and/or death anxiety...

Abstract BACKGROUND Patients diagnosed with brain tumors experience significant cognitive sequelae, yet they remain underrepresented in behavioral intervention research. We present the development and initial results from pilot study of C-SMART (Cognitive Strategies, Mindfulness, Rehabilitation Therapy), an integrated rehabilitation mindfulness for patients tumor mild decline. incorporated key stakeholders content experts’ opinions as a critical first step developing empirically supported...

Abstract BACKGROUND Patients with both primary and secondary brain tumors demonstrate substantial psychological distress but have been historically excluded from research. Managing Cancer Living Meaningfully (CALM), a supportive- expressive- psychotherapy, has proven to reduce depression death-anxiety in advanced cancer patients trials neuro-oncology limited. Interim analyses (50% accrual) of the first randomized control pilot trial (RCT) CALM are presented here. METHODS In this ongoing NIH...

Abstract BACKGROUND Cognitive decline, common in patients with gliomas, can contribute to reduced independence daily functioning. Patients gliomas often rely on informal caregivers for functional support, evidenced cause distress other caregiver populations (e.g., Alzheimer’s, terminal cancer, dementia). Few studies have investigated this relationship neuro-oncology; thus, we explored whether patients’ neurocognitive function was associated aspects of burden. METHODS glioma underwent testing...

Abstract BACKGROUND Brain tumor diagnosis and treatment result in significant negative sequelae, including cognitive decline, fatigue, psychosocial symptoms. This study aimed to identify brain patients’ sources of cancer-related distress examine their interest various modalities targeting decline inform program development for this underserved population. METHODS In pursuit development, patients with both primary secondary tumors completed an anonymous survey. They reported demographics,...

Abstract BACKGROUND Individuals with glioma endorse fear of cancer recurrence (FCR), but existing interventions for FCR are not entirely translatable to neuro-oncology. We consulted international experts and advisory boards comprised neuro-oncology professionals, patients, caregivers assist in creating a 6-module psychotherapy targeting patients caregivers: FearLess Neuro-Oncology. Intervention modules will be discussed in-depth. METHODS The ongoing telehealth pilot aims enroll 24...

Abstract BACKGROUND The COVID-19 pandemic altered the delivery of healthcare services globally with a rapid adoption telemedicine to meet patient’s needs. Telemedicine is critical for neuro-oncology patients who may be at an increased risk infection, yet require continuity care. An important aspect care includes neuropsychological assessment, which can challenging complete outside structured testing environment. Teleneuropsychology (TNP) has been explored under proctored conditions and...

Abstract INTRODUCTION Chimeric Antigen Receptor T-cell (CAR-T) therapy carries risk of significant neurocognitive function (NCF) toxicities. Longer term NCF outcomes have yet to be reported. The goal the current study was assess prospectively in patients undergoing CAR-T. METHODS Adult CAR-T participated testing with a cognitive clinical trial battery (CTB) at baseline and 6 months after treatment. Group change on each test composite score (CTBC) examined paired t-tests individual change,...

Abstract BACKGROUND Patients with brain cancer demonstrate substantial psychological distress yet are frequently excluded from research. Managing Cancer and Living Meaningfully (CALM), an expressive-supportive psychotherapy designed to address the challenges faced by patients advanced cancer. CALM is proven reduce depression death-related distress; however, metastases (bMETs) have not been formally examined for CALM’s appropriateness or effectiveness. METHODS In this ongoing Phase II trial,...

Abstract BACKGROUND Many patients with brain tumors experience double vulnerability—significant emotional distress coupled cognitive decline—however, these changes often prohibit their inclusion in psychotherapeutic interventions that might otherwise improve wellbeing. The primary goal of this analysis was to understand how best accommodate the neurocognitive needs so they may effectively participate future interventions. Our secondary assess potential differences desired adaptations between...

Abstract Objective The ACE-III is a brief cognitive screener with high sensitivity and specificity in detecting neurocognitive disorders. We examined the utility of subscale scores (Attention/Orientation, Memory, Fluency, Language, Visuospatial) to predict performance on expanded neuropsychological evaluation detect diagnostic group differences. Data Selection 217 patients (Mag = 74.0, Medu 15.78) concerns completed followed by comprehensive evaluation, including Wechsler Adult Intelligence...

Abstract INTRODUCTION Subjective cognitive dysfunction is an important outcome measure in neuro-oncology and may provide additional information beyond performance-based neuropsychological testing. The Functional Assessment of Cancer Therapy-Brain (FACT-Br) a frequently used quality life (QoL) that includes indices physical, emotional, social, neurologic aspects disease, but does not concerns. This study seeks to develop validate index self-reported cognition derived from existing items on...

Abstract PURPOSE To report preliminary results on outcomes of patients with lower grade gliomas (LGG) treated proton therapy. METHODS Patients II or IDH mutant III glioma and indications for radiation therapy were enrolled in a prospective single arm trial (PRT), receiving dose 54 Gy(RBE) 59.4 Gy(RBE), respectively. Comprehensive baseline regular post-treatment evaluations neuroendocrine function, neurocognitive functions (NCF), quality life (QOL), progression-free survival (PFS) performed....

Abstract INTRODUCTION Our group previously demonstrated stability in neurocognitive function (NCF) over a 5-year period after proton radiation therapy (PRT) low grade glioma (LGG) patients. Subjective cognitive (SCF) had not been explored, nor individual analyses of cognition, which can detect variability trajectory. We used the newly derived Functional Assessment Cancer Therapy-Brain Cognitive-Index (FACT-Br-CI) to examine SCF LGG patients PRT and compare longitudinal changes NCF. METHODS...

Abstract INTRODUCTION Estimates of subjective cognitive function (SCF) generally show minimal correlation with objective measures neurocognitive (NCF). Our group recently validated a new metric SCF in neuro-oncology patients, creating the Cognitive Index Functional Assessment Cancer Therapy-Brain (FACT-Br-CI). This study examines whether brain tumor (BT) patients evaluated on more than one occasion improved relationship between and NCF. We hypothesized that change scores NCF across...