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Jeffrey Varnes

ORCID: 0009-0009-6257-8063
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A5073103325
Research Areas
  • Synthesis and Catalytic Reactions
  • Mast cells and histamine
  • Immune cells in cancer
  • Cancer Research and Treatments
  • Cancer, Stress, Anesthesia, and Immune Response
  • Immune Cell Function and Interaction
  • Inflammatory mediators and NSAID effects
  • Cancer Immunotherapy and Biomarkers
  • Amino Acid Enzymes and Metabolism
 Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

Abstract Antitumor immunity can be hampered by immunosuppressive mechanisms in the tumor microenvironment, including recruitment of arginase (ARG) expressing myeloid cells that deplete l-arginine essential for optimal T-cell and natural killer cell function. Hence, ARG inhibition reverse immunosuppression enhancing antitumor immunity. We describe AZD0011, a novel peptidic boronic acid prodrug to deliver an orally available, highly potent, inhibitor payload (AZD0011-PL). demonstrate...

10.1158/1535-7163.mct-22-0431 article EN Molecular Cancer Therapeutics 2023-03-13
 Supplementary Figure 4 from Novel arginase inhibitor, AZD0011, demonstrates immune cell stimulation and anti-tumor efficacy with diverse combination partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 4</p>

10.1158/1535-7163.27035725 preprint EN 2024-09-16
 Supplementary Figure 2 from Novel arginase inhibitor, AZD0011, demonstrates immune cell stimulation and anti-tumor efficacy with diverse combination partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 2</p>

10.1158/1535-7163.27035731 preprint EN 2024-09-16
 Supplementary Figure 3 from Novel arginase inhibitor, AZD0011, demonstrates immune cell stimulation and anti-tumor efficacy with diverse combination partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 3</p>

10.1158/1535-7163.27035728 preprint EN 2024-09-16
 Supplementary Figure 5 from Novel arginase inhibitor, AZD0011, demonstrates immune cell stimulation and anti-tumor efficacy with diverse combination partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 5</p>

10.1158/1535-7163.27035722 preprint EN 2024-09-16
 Supplementary Figure 1 from Novel arginase inhibitor, AZD0011, demonstrates immune cell stimulation and anti-tumor efficacy with diverse combination partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 1</p>

10.1158/1535-7163.27035734 preprint EN 2024-09-16
 Data from Novel arginase inhibitor, AZD0011, demonstrates immune cell stimulation and anti-tumor efficacy with diverse combination partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<div>Abstract<p>Anti-tumor immunity can be hampered by immunosuppressive mechanisms in the tumor microenvironment including recruitment of arginase (ARG) expressing myeloid cells which deplete L-arginine essential for optimal T cell and natural killer function. Hence, ARG inhibition reverse immunosuppression enhancing anti-tumor immunity. We describe AZD0011, a novel peptidic boronic acid prodrug to deliver an orally available, highly potent, inhibitor payload (AZD0011-PL)....

10.1158/1535-7163.c.6611322.v3 preprint EN 2024-09-16
 Supplementary Figure 5 from Novel arginase inhibitor, AZD0011, demonstrates immune cell stimulation and anti-tumor efficacy with diverse combination partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 5</p>

10.1158/1535-7163.27035722.v1 preprint EN 2024-09-16
 Supplementary Figure 4 from Novel arginase inhibitor, AZD0011, demonstrates immune cell stimulation and anti-tumor efficacy with diverse combination partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 4</p>

10.1158/1535-7163.27035725.v1 preprint EN 2024-09-16
 Supplementary Figure 3 from Novel arginase inhibitor, AZD0011, demonstrates immune cell stimulation and anti-tumor efficacy with diverse combination partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 3</p>

10.1158/1535-7163.27035728.v1 preprint EN 2024-09-16
 Supplementary Figure 1 from Novel arginase inhibitor, AZD0011, demonstrates immune cell stimulation and anti-tumor efficacy with diverse combination partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 1</p>

10.1158/1535-7163.27035734.v1 preprint EN 2024-09-16
 Supplementary Figure 2 from Novel arginase inhibitor, AZD0011, demonstrates immune cell stimulation and anti-tumor efficacy with diverse combination partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 2</p>

10.1158/1535-7163.27035731.v1 preprint EN 2024-09-16
 Data from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<div>Abstract<p>Antitumor immunity can be hampered by immunosuppressive mechanisms in the tumor microenvironment, including recruitment of arginase (ARG) expressing myeloid cells that deplete l-arginine essential for optimal T-cell and natural killer cell function. Hence, ARG inhibition reverse immunosuppression enhancing antitumor immunity. We describe AZD0011, a novel peptidic boronic acid prodrug to deliver an orally available, highly potent, inhibitor payload (AZD0011-PL)....

10.1158/1535-7163.c.6611322.v1 preprint EN 2023-04-21
 Supplementary Figure 1 from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 1</p>

10.1158/1535-7163.22674525 preprint EN cc-by 2023-04-21
 Supplementary Figure 4 from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 4</p>

10.1158/1535-7163.22674516.v1 preprint EN cc-by 2023-04-21
 Supplementary Figure 5 from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 5</p>

10.1158/1535-7163.22674513 preprint EN cc-by 2023-04-21
 Supplementary Figure 2 from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 2</p>

10.1158/1535-7163.22674522.v1 preprint EN cc-by 2023-04-21
 Supplementary Figure 2 from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 2</p>

10.1158/1535-7163.22674522 preprint EN cc-by 2023-04-21
 Supplementary Figure 5 from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 5</p>

10.1158/1535-7163.22674513.v1 preprint EN cc-by 2023-04-21
 Supplementary Figure 3 from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 3</p>

10.1158/1535-7163.22674519 preprint EN cc-by 2023-04-21
 Supplementary Figure 4 from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners
OPENALEX - Publications 
Aatman S. Doshi Susan Cantin Marylens Hernandez Srimathi Srinivasan Sharon Tentarelli and 23 more Matthew Griffin Yanjun Wang Petar Pop-Damkov Laura B. Prickett Cecilia Kankkonen Minhui Shen Maryann San Martin Song Wu M. Paola Castaldi Hormas Ghadially Jeffrey Varnes Sonya Gales David Henry Clare Hoover Deanna A. Mele Iain Simpson Eric T. Gangl Scott N. Mlynarski M. Raymond V. Finlay Lisa Drew Stephen E. Fawell Wenlin Shao Alwin G. Schuller

<p>Supplementary Figure 4</p>

10.1158/1535-7163.22674516 preprint EN cc-by 2023-04-21
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