A5077964734- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Animal health and immunology
- Actinomycetales infections and treatment
- Animal Virus Infections Studies
- Vibrio bacteria research studies
- Cancer Research and Treatments
- MicroRNA in disease regulation
- HIV/AIDS Research and Interventions
- Plant and fungal interactions
- HIV/AIDS drug development and treatment
- Mechanical Failure Analysis and Simulation
- Agricultural Systems and Practices
- Identification and Quantification in Food
- Fungal Infections and Studies
- Knee injuries and reconstruction techniques
- Cancer Cells and Metastasis
- melanin and skin pigmentation
- Cancer-related Molecular Pathways
- Elasticity and Material Modeling
- Mitochondrial Function and Pathology
- Microbial infections and disease research
- CAR-T cell therapy research
- Viral Infections and Immunology Research
- T-cell and Retrovirus Studies
Indiana University
2024
Indiana University School of Medicine
2024
University School
2024
University of Colorado Denver
2011-2015
University of Colorado Anschutz Medical Campus
2011
The University of Texas Southwestern Medical Center
1996
Agricultural Research Service
1971-1973
National Animal Disease Center
1971-1973
Oak Ridge Associated Universities
1973
Oak Ridge National Laboratory
1972-1973
Mutation of either two critical human immunodeficiency virus type 1 (HIV-1) regulatory proteins, Tat and Rev, results in marked defects viral replication. Thus, inhibition the function one or both these proteins can significantly inhibit growth. In present study, we constructed a novel transdominant mutant protein compared its efficiency inhibiting HIV-1 replication with that Rev M10 when were stably expressed alone combination T-lymphocyte cell lines. The resulted modest HIV replication,...
SUMMARY Proteus mirabilis was obtained in pure culture from the organs of 58 clinically ill C 3 H/HeJ mice killed and necropsied over a period 28 months. Affected were found breeding colony, among animals involved experimental studies, stock being held for future experiments. Of infected mice, 26 had grossly visible renal lesions. Histologic examinations revealed lesions typical purulent nephritis septicemia. Many rod-shaped bacteria areas inflammation. intestinal tract large percentage but...
Isotope uptake in embryos and tissues of pregnant mice was determined 24 hr after intravenous inoculation with either 67Ga or [3H]TdR. concentration associated maternal tissue at 6–8 days comparable to values reported previously normal adult mouse tissues, whereas 9–11 days, it equaled surpassed concentrations leukemic AKR BALB/c mice. By Day 13, counts were diminished the embryos. The thymus decreased progressively increasing gestation time, as did [3H]TdR embryonic tissue. Autoradiograms...
Background and Hypothesis:A human placental-derived extracellular matrix (ECM) allograft has previously been developed is indicated by the manufacturer for reducing tissue inflammation accelerated repair. To evaluate efficacy of this product post-anterior cruciate ligament (ACL) injury inflammation, we used a novel murine in vivo ACL model. This model shown to induce significant synovitis, infrapatellar fat pad (IFP) fibrosis, articular cartilage (AC) degradation within 2 weeks following an...
Background and Hypothesis:Previous research indicated that fatigue loading of the anterior cruciate ligament (ACL) leads to disruption unraveling collagen triple helix structure. Using a novel in vivo murine model, we have spectroscopically shown at molecular level is associated with an increase proteoglycan activity. Moreover, found tissue compliance within these damaged domains. We hypothesize activity largely responsible for this mechanical change. To investigate this, first need identify...
SUMMARY Vibrio fetus strains representing 3 biotypes (type 1, subtype and type 2) were parenterally inoculated into cattle (18), sheep (21), rabbits (25), guinea pigs (46), mice (168) to determine which types would establish infection in gallbladder or intestines. Type 2 V. was recovered cultures of intestines from (75%) the 4 cattle, 6 (87%) 7 sheep, 5 (63%) 8 rabbits, (33%) pigs, 23 (83%) 28 with this type. 1 not any these strains. pig, mouse. The results indicated that could be...
SUMMARY A survey was made to determine the prevalence of Vibrio fetus infection gallbladder in cattle and sheep slaughtered at abattoirs Iowa. Bile specimens were collected from 525 selected random when slaughtered, 186 9 flocks. species isolated 88 (17%) sampled 29 (16%) sheep. Sixtyfive isolates 17 classed as V. , whereas 23 12 fecalis or unclassifiable on basis results morphologic, biochemical, serologic tests. To test pathogenicity, strains each 4 distinct groups bovine bile inoculated...