A5044520296- Sphingolipid Metabolism and Signaling
- Marine Sponges and Natural Products
- Cancer, Hypoxia, and Metabolism
- Pharmacological Receptor Mechanisms and Effects
- Bioactive Compounds and Antitumor Agents
- Cancer Research and Treatment
- Plant-derived Lignans Synthesis and Bioactivity
- Glycosylation and Glycoproteins Research
- Lipid Membrane Structure and Behavior
- Lipid metabolism and biosynthesis
- Cancer Treatment and Pharmacology
- Flavonoids in Medical Research
- Cancer and biochemical research
- Cancer Research and Treatments
- Histone Deacetylase Inhibitors Research
University of Alabama at Birmingham
2024-2025
Xavier University of Louisiana
2021-2023
Ceramides are sphingolipids that act as signaling molecules involved in regulating cellular processes including apoptosis, proliferation, and metabolism. Deregulation of ceramide metabolism contributes to cancer development progression. Therefore, regulation levels cells is being explored a new approach for therapy. This review discusses the multiple roles ceramides strategies modulate attenuate cell survival metabolic pathways, while activating apoptotic mechanisms, making them...
Abstract Introduction: Colorectal cancer (CRC) remains one of the most common and deadly cancers in US. Despite advances treatment, once CRC is metastatic (spread from original tumor site to other parts body), 5-year survival rate 20%. Metastasis requires a complex series events, including release cells origin site. Tumor adhere each via adhesive cell-cell junctions, family these called desmosomes. A key desmosomal protein Desmoglein-2 (DSG2), which cell surface protein. DSG2 function could...
We have previously reported that treating triple-negative tumor bearing nude mice with intraperitoneal (ip) 10 mg/kg body weight of (S,E)-3-hydroxy-2-(2-hydroxybenzylidene)amino-N-tetradecylpropanamide, a ceramide analog, 5 days per week for 3 weeks, was shown not only to suppress growth but also reduce metastasis. Studies here focus on determining the toxicity this drug in mice. During first study, treated animals (single injection, 0, 40, 80 and 120 weight) were closely monitored 14 any...
Many current anti-cancer drugs used to treat breast cancer mediate tumor cell death through the induction of apoptosis. Cancer cells, however, often acquire multidrug-resistance following prolonged exposure chemotherapeutics. Consequently, molecular pathways involved in proliferation have become potential targets for pharmacological intervention. Ceramides are suppressor lipids naturally found membrane, and central molecules sphingolipid signalling pathway.
Introduction Ceramides are known to show anti-cancer activity. A novel ceramide analog, (S,E)-3-hydroxy-2-(2-hydroxybenzylidene)amino-N-tetradecylpropanamide (analog 315) was developed as part of a larger study focused on finding more effective breast cancer treatments. Objective To assess whether analog 315 shows any or combination the following effects in cells vitro: inhibiting proliferation, inducing apoptosis, and altering protein expression. Also, determine it inhibits chemo-resistant...
Abstract Globally, breast cancer is the most frequently diagnosed in women, with an estimated 281,550 new cases U.S.A 2021. About 43,600 women U.S. are expected to die from disease by end of year. Chemo- and radio-therapies, primarily, exert anti-tumor effects through activation apoptosis, or programmed cell death pathways. As many current therapies have severe side effects, and/or lose their effectiveness over time due developed resistance, there a need for novel agents that can improve...