A5027351506- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- Vaccine Coverage and Hesitancy
- Reproductive System and Pregnancy
- Liver physiology and pathology
- Neuroendocrine Tumor Research Advances
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Pancreatitis Pathology and Treatment
- COVID-19 Impact on Reproduction
- Pancreatic and Hepatic Oncology Research
- Hemophilia Treatment and Research
- Liver Disease and Transplantation
- COVID-19 epidemiological studies
- Dermatological diseases and infestations
- Travel-related health issues
- Ultrasound Imaging and Elastography
- Hepatitis Viruses Studies and Epidemiology
- Infectious Diseases and Mycology
- Proteoglycans and glycosaminoglycans research
- Ocular Infections and Treatments
- Animal Virus Infections Studies
- Ultrasound and Hyperthermia Applications
- Immunotherapy and Immune Responses
Topiwala National Medical College & BYL Nair Charitable Hospital
2020-2025
Kasturba Hospital
2020-2022
Victoria Hospital
2020-2021
Takeda (United States)
2016-2019
Baxalta (United States)
2016-2019
UCB Pharma (Belgium)
2006
National Institute of Immunology
1992-1994
We report here results of clinical trials on a birth control vaccine, consisting heterospecies dimer the beta subunit human chorionic gonadotropin (hCG) associated noncovalently with alpha ovine luteinizing hormone and conjugated to tetanus diphtheria toxoids as carriers, that induces antibodies high avidity (K(a) approximately 10(10) M-1) against hCG. Fertile women exposed conception over 1224 cycles recorded only one pregnancy at antibody titers > 50 ng/ml (hCG bioneutralization...
Background: Post infection immunity and post vaccination both confer protection against COVID-19. However, there have been many whole genome sequencing proven reinfections breakthrough infections. Both are most often mild caused by Variants of Concern (VOC). Methods: The patient in our study underwent serial COVID-19 RT-PCR, blood tests for serology, acute phase reactants, chest imaging as part clinical care. We interviewed the history retrieved reports case papers. stored RT-PCR positive...
Antibodies play a role in herd immunity, and studies estimate that COVID-19 antibody protection lasts approximately 1 to 4 months following vaccination 6 8 infection. As healthcare workers frontline were highly exposed the infection, it is necessary know if they have developed immunity against COVID-19. To seroprevalence of SARS-CoV-2 antibodies among health care Mumbai qualitatively quantitatively observe change levels after months. This longitudinal study was conducted over 9 two phases...
Background: SARS-CoV-2 infection may not provide long lasting post-infection immunity. While hundreds of reinfections have reported only a few been confirmed. Whole genome sequencing (WGS) the viral isolates from different episodes is mandatory to establish reinfection. Methods: Nasopharyngeal (NP), oropharyngeal (OP) and whole blood (WB) samples were collected paired four individuals who suspected reinfection based on distinct clinical RT-PCR tests. Details their case record files...
Infectious respiratory particles expelled by SARS-CoV-2 positive patients are attributed to be the key driver of COVID-19 transmission. Understanding how and whom virus is transmitted can help implement better disease control strategies. Here we have described use a noninvasive mask sampling method detect quantify RNA in discussed its relationship transmission risk. Respiratory 31 symptomatic asymptomatic healthy volunteers were captured on N-95 masks layered with gelatin membrane 30-minute...
Background: Frontline healthcare workers (HCWs) are exceedingly exposed to SARS-CoV-2 and reinfections a possibility. A RT-PCR positive test does not confirm reinfection. Whole genome sequencing (WGS) of the viral isolates from different episodes can Methods: RNA was extracted nasopharyngeal plus oropharyngeal samples four HCWs who were in May/June then again July. Anti-NC antibody testing performed after second infection three HCWs. The subjected whole comparative protein-based functional...
Previous studies have shown antifibrotic effects of somatostatin. Since hepatic stellate cells (HSC) express somatostatin receptors and play a key role in fibrogenesis, we investigated the vitro effect on rat HSC. At day 12 after isolation, were exposed to different concentrations (10(-6)-10(-9) mol l(-1)). mRNA expression collagen types I III, smooth muscle alpha-actin (alpha-SMA) was analysed by Northern blotting. 10(-9) l(-1), significantly reduced (72.3 +/- 10.7%; 95% confidence interval...
Somatostatin has been used for over two decades to treat acute variceal bleeding. Although it is assumed that somatostatin lowers portal pressure by constriction of the splanchnic arteries, little known about expression receptors (SSTR) in blood vessels. In this study we investigated SSTR vessels from normal and cirrhotic rats.Cirrhosis was induced intraperitoneal injection 50 mg thioacetamide twice a week 14 weeks. vein, mesenteric artery aorta rats, mRNA five measured quantitative reverse...
The role of sMAdCAM, an important gut immune migratory marker, remains unexplored in COVID-19 pathogenesis considering recent studies positing the as a sanctuary site for SARS-CoV-2 persistence. Thus, assimilating profiles systemic inflammatory mediators with sMAdCAM levels may provide insights into progression disease. Also, these markers governing virus specific immunity following infection largely unexplored. A cohort (n = 84) SARS-C0V-2 infected individuals included group in-patients 60)...
Objectives: Somatostatin inhibitory effect on the exocrine pancreas has been demonstrated by clinical and experimental studies performed with invasive investigative methods. The aim of this study was to quantify low doses somatostatin (62.5, 125, 250 μg) secretin-stimulated pancreatic secretions using magnetic resonance cholangiopancreatography (MRCP). Methods: Ten healthy volunteers underwent 4 MRCP at a 1-week interval. At each MRCP, 1 3 or placebo given intravenous route for period 40...
Background: Infectious respiratory particles expelled by SARS-CoV-2 positive patients are attributed to be the key driver of COVID-19 transmission. Understanding how and whom virus is transmitted can help implement better disease control strategies. Here we have described use a noninvasive mask sampling method detect quantify RNA in discussed its relationship transmission risk.Methods: Respiratory 31 symptomatic with confirmed positivity asymptomatic healthy volunteers were captured on N-95...
Two vaccines inducing antibodies against human chorionic gonadotropin (hCG) have completed Phase I clinical trials, indicating the reversibility and safety of these vaccines. One is currently in II efficacy trials women three major centres India. The available data suggest that vaccine prevents pregnancy above antibody titres 50 ng/ml hCG bioneutralization capacity.
We report here the genome sequences of SARS-CoV-2 variants from five COVID-19 patients in Mumbai, India. Viral genomic RNA was isolated nasopharyngeal swabs and/or respiratory particles masks patients. Genomic variant analysis determined 8 to 22 mutations, and belong lineages previously associated with Indian variants.
Ophthalmomyiasis is the infestation of ocular structures by fly larvae (maggots). Oestrus ovis common among them. This usually observed in rural areas, but a case presented here from urban areas. Depending on species and structure involved, manifestations vary self-limiting condition to optic nerve involvement which may lead blindness, hence, identification prompt management necessary. report alerts ophthalmologists areas consider time also microbiologists for rapid identification.
Context: Neonatal sepsis is a clinical syndrome of bacteraemia characterized by systemic signs and symptoms infection in the first month life.Blood culture mainstay diagnosis but it has long turnaround time delay instituting therapy affects outcome.Taking this into perspective, present study was undertaken to find out importance two inflammatory markers rapid neonatal sepsis.Aim: To compare utility Interleukin-6 Tumour necrosis factor-α with automated blood sepsis.Settings Design: A...