A5074697996- 3D Printing in Biomedical Research
- Spaceflight effects on biology
- Hydrogels: synthesis, properties, applications
- Graphene and Nanomaterials Applications
- Head and Neck Cancer Studies
- Ocular Oncology and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Multiple Myeloma Research and Treatments
- Additive Manufacturing and 3D Printing Technologies
- Cutaneous Melanoma Detection and Management
- Oral Health Pathology and Treatment
- Vascular Tumors and Angiosarcomas
- Melanoma and MAPK Pathways
- Autopsy Techniques and Outcomes
- Collagen: Extraction and Characterization
- Surface Modification and Superhydrophobicity
- Chronic Lymphocytic Leukemia Research
- Botulinum Toxin and Related Neurological Disorders
- Viral-associated cancers and disorders
- Cellular Mechanics and Interactions
- Mechanisms of cancer metastasis
- Graphene research and applications
- Bone Tumor Diagnosis and Treatments
- Cell death mechanisms and regulation
- Tissue Engineering and Regenerative Medicine
Université Libre de Bruxelles
2022-2024
University of L'Aquila
1995-2012
San Salvatore Hospital
1995-2012
Ospedale Maggiore
2006
Three-dimensional (3D) bio-printing has recently emerged as a crucial technology in tissue engineering, yet there are still challenges selecting materials to obtain good print quality. Therefore, it is essential study the influence of chosen material (i.e., bio-ink) and printing parameters on final result. The “printability” bio-ink indicates its suitability for bio-printing. Hydrogels great choice because their biocompatibility, but printability exploiting properties ensuring high accuracy....
Scaffolds have been used to stimulate cell migration, adhesion, and proliferation as extracellular matrix analogues. This study proposes a novel method for creating hybrid alginate-gelatine aerogel-based scaffold, which could be suitable adhesion. To this end, at 4% was first make stable hydrogels, were then frozen -70°C dried under vacuum produced aerogels. Aerogels are materials known their extremely low density, which, by definition, should lower than 0.5 g/cm <sup...
Abstract Laser-induced graphene (LIG) possesses desirable properties for numerous applications. However, LIG formation on biocompatible substrates is needed to further augment the integration of LIG-based technologies into nanobiotechnology. Here, cross-linked sodium alginate reported. The systematically investigated, providing a comprehensive understanding physicochemical characteristics material. Raman spectroscopy, scanning electron microscopy with energy-dispersive x-ray analysis,...
In the process of tissue engineering, several types stresses can influence outcome regeneration. This be understood by designing hydrogels that mimic this and studying how such hydrogel scaffolds cells behave under a set stresses. Here, formulation is proposed to create biomimetic suitable for fibroblast cell culture. Subsequently, we examine impact external on cultured both solid porous hydrogels. These included mechanical tension altered-gravity conditions experienced during 83rd parabolic...
Abstract Exposure to altered gravity influences cellular behaviour in cell cultures. Hydrogels are amongst the most common materials used produce tissue-engineering scaffolds, and their mechanical properties play a crucial role cell-matrix interaction. However, little is known about influence of on hydrogel properties. Here we study Poly (ethylene glycol) diacrylate (PEGDA) PEGDA incorporated with graphene oxide (GO) by performing tensile tests micro hypergravity during Parabolic flight...
The present study examines the formulation of a biocompatible hydrogel bioink for 3D bioprinting, integrating poly(ethylene glycol) diacrylate (PEGDA) and sodium alginate (SA) using double-network approach. These materials were chosen their synergistic qualities, with PEGDA contributing to mechanical integrity SA ensuring biocompatibility. Fibroblast cells included in printed Reg4Life bioprinter employing micro-extrusion technology. optimisation printing parameters needle size flow...
The incidence of cutaneous melanoma is constantly rising. Ocular involvement rare and the choroid most accessible structure to metastatic emboli. case described noteworthy on account several particular features: 1) missed diagnosis primary malignancy. This might be because either or nevi show common features; 2) rarity retinal site. Unlike choroid, retina an unusual site but, regardless organ blood flow, efficiency may related interactions between tumor cells host tissue; 3) treatment...
Uveal melanoma is characterized by an unpredictable clinical course, during which metastatic disease may occur after a prolonged and, at present, undefinable disease-free interval. Because of its relative rarity and the dispersion cases, possible genetic alterations implicated in invasive behaviour this ocular neoplasm have not yet been characterized. The aim immunohistochemical retrospective study was to assess expression nm23 gene product, proposed be metastasis-suppressor gene, uveal...
Abstract In applications related to remote areas and microgravity experiments, access proper CO 2 incubation for in vitro experiments is difficult and, some cases, impossible. It important assess the time period which one can handle transport cells whilst maintaining a reasonable viability. The effects of carbon dioxide (CO ) deficiency, an environment, on viability morphology fibroblast are looked at this work. A -free environment was provided cells, their behavior tracked over established...
One of the main challenges in tissue engineering is to assemble functional constructs able restore damaged tissues. This has led development classes materials with tuneable structural, mechanical and absorption properties. Among others, hydrogels are particularly fascinating because they can be functionalized self-repair structural damage recover pristine properties, like native living tissues do. The present study proposes an improved thermo-responsive alginate-gelatine (SA-Gel) hydrogel...
Purpose: The purpose of the study was to evaluate efficacy botulinum toxin type A (BTX-A) injection in patients with acquired VI nerve palsy. Methods: Twenty-eight (16 F and 12 M), mean age 36.4 +/-- 17.8 DS; range 10 - 69 years palsy, have been treated BTX-A into ipsilateral medial rectus, at least 6 months after onset. At follow up, a paresis paralysis, were respectively diagnosed if affected eye could be actively abducted or not, across mid-line; simple horizontal rectus muscle procedure...