A5003347403- Pharmacogenetics and Drug Metabolism
- Biomedical Text Mining and Ontologies
- Pharmaceutical studies and practices
- Genomics and Rare Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Statistics Education and Methodologies
- Electronic Health Records Systems
- Pharmaceutical Practices and Patient Outcomes
- Census and Population Estimation
- Pancreatic and Hepatic Oncology Research
- Neutropenia and Cancer Infections
- Colorectal Cancer Treatments and Studies
- Statistical Methods and Bayesian Inference
St Mary's Hospital
2023-2025
St. Mary's Hospital
2023-2025
Manchester University NHS Foundation Trust
2023-2025
St Mary's Hospital
2025
University of Manchester
2024
St. Mary’s Hospital
2024
Pharmacogenetics can impact patient care and outcomes through personalizing the selection of medicines, resulting in improved efficacy a reduction harmful side effects. Despite existence compelling clinical evidence international guidelines highlighting benefits pharmacogenetics practice, implementation within National Health Service United Kingdom is limited. An important barrier to overcome development IT solutions that support integration pharmacogenetic data into health systems. This...
Study objectives Describe the implementation of an interoperable solution to support pharmacogenomic-guided prescribing in primary care National Health Service, England. Methods We used iterative approach software development going through clinical workflow mapping, architecture design and development, pilot-testing. Results configured a commercial health data management platform store pharmacogenomic results structured format created knowledge base guidance. This was deployed ‘as-a-service’...
Aims Pharmacogenomics enables personalization of drug therapy improving effectiveness and/or safety. Dihydropyrimidine dehydrogenase [DPYD] testing prior to fluoropyrimidine chemotherapy was commissioned by NHS England in response an update from the Medicines and Healthcare products Regulatory Agency. Methods A questionnaire developed approved National DPYD Working Group investigated processes testing, receiving responding results. The survey distributed Genomics Medicine Service Alliance...
<sec> <title>BACKGROUND</title> Pharmacogenetics, a subset of precision medicine, leverages genetic testing to improve the safety and efficacy prescribed medicines. Despite compelling evidence supporting its clinical economic impact, widespread implementation remains limited. An established barrier is lack interoperable health information technology solutions that integrate pharmacogenetic data into frontline workflows, particularly for non-specialist clinicians. Open standards, such as...
Pharmacogenetic testing in the United Kingdom's National Health Service (NHS) has historically been reactive nature, undertaken context of single gene-drug relationships specialist settings. Using a discrete choice experiment we aimed to identify healthcare professional preferences for development pharmacogenetic service primary care NHS. Respondents, representing two professions groups (general practitioners or pharmacists), completed one survey versions, asking them select their preferred...
<sec> <title>BACKGROUND</title> Pharmacogenetics can impact patient care and outcomes through personalizing the selection of medicines, resulting in improved efficacy a reduction harmful side effects. Despite existence compelling clinical evidence international guidelines highlighting benefits pharmacogenetics practice, implementation within National Health Service United Kingdom is limited. An important barrier to overcome development IT solutions that support integration pharmacogenetic...