A5078790545- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Drug-Induced Adverse Reactions
- Eosinophilic Disorders and Syndromes
- Congenital Anomalies and Fetal Surgery
- Cancer, Hypoxia, and Metabolism
- Congenital limb and hand anomalies
- Inflammatory Myopathies and Dermatomyositis
- Mobile Health and mHealth Applications
- ICT in Developing Communities
- Ophthalmology and Visual Health Research
- Assisted Reproductive Technology and Twin Pregnancy
- Congenital Heart Disease Studies
- Skin Diseases and Diabetes
- Gynecological conditions and treatments
- Cytomegalovirus and herpesvirus research
- Health and Well-being Studies
- Clostridium difficile and Clostridium perfringens research
- Melanoma and MAPK Pathways
- Dermatological and Skeletal Disorders
- Traffic and Road Safety
- Automotive and Human Injury Biomechanics
- Muscle Physiology and Disorders
- Microtubule and mitosis dynamics
MRC London Institute of Medical Sciences
2023-2024
Imperial College London
2024
University of Manchester
2023-2024
Great Ormond Street Hospital
2023
University College London
2023
National Institute for Health Research
2023
Liverpool School of Tropical Medicine
2016
University of Colorado Denver
1998-2007
Queen Charlotte's and Chelsea Hospital
2005
University of Colorado Anschutz Medical Campus
1998
Abnormal increases in cell size are associated with senescence and cycle exit. The mechanisms by which overgrowth primes cells to withdraw from the remain unknown. We address this question using CDK4/6 inhibitors, arrest G0/G1 licensed treat advanced HR+/HER2- breast cancer. demonstrate that CDK4/6-inhibited overgrow during G0/G1, causing p38/p53/p21-dependent withdrawal. Cell withdrawal is triggered biphasic p21 induction. first wave caused osmotic stress, leading p38- size-dependent...
The conversion of fibroblasts into myogenic cells is a powerful tool to both develop and test therapeutic strategies perform in-depth investigations neuromuscular disorders, avoiding the need for muscle biopsies. We developed an easy, reproducible, high-efficiency lentivirus-mediated transdifferentiation protocol, that can be used convert healthy donor promising new cellular model, urinary stem (USCs), myoblasts, further differentiated multinucleated myotubes in vitro . Transcriptome...
Background Source data verification (SDV) is a monitoring procedure which compares the original records with Case Report Form (CRF). Traditionally, on-site SDV relies on monitors making multiples visits to study sites requiring extensive resources. The Cooking And Pneumonia Study (CAPS) 24- month village-level cluster randomized controlled trial assessing effectiveness of an advanced cook-stove intervention in preventing pneumonia children under five rural Malawi (www.capstudy.org). CAPS...
Abstract Multiple abnormalities of a fetus were detected on routine antenatal anomaly scan at 19 weeks' gestation. Amniocentesis and karyotype analysis showed trisomy 22. The ultrasound postmortem features are presented. Copyright © 1995 International Society Ultrasound in Obstetrics Gynecology
Abstract As the initial stage in developing a curriculum to assist family physicians diagnose and manage alcohol abuse their practices, questionnaires were mailed selected group of physicians. A total 117 (34%) completed questionnaire. The majority (70.1%) reported that fewer than 10% caseload experienced alcohol-related problems. Most (59.3%) did not use any stadard diagnostic instruments but screening detection was most challenging problem along with patient management. questionnaire...
Abstract Breast cancer is the most common type in world. Approximately 70% of pre-malignant breast tumours, known as ductal carcinoma situ (DCIS), and 20% invasive tumours overexpress HER2. Although molecular mechanisms HER2 function tumour cells have been extensively studied, our knowledge on how drives tumourigenesis at its stage quite limited. Here, we investigate HER2-overexpression driven cellular events earliest stages using vitro, vivo ex models. Using mouse models HER2+ clinical...
Secreted proteins regulate the balance between cellular proliferation and G0 arrest therefore play important roles in tumour dormancy. Tumour dormancy presents a significant clinical challenge for breast cancer patients, where non-proliferating, G0-arrested cells remain at metastatic sites, below level of detection, some which can re-enter drive relapse. Knowing secreted entry into exit from allows us to manipulate their signalling prevent To identify novel that promote arrest, we performed...
Abstract Breast cancer is the most common globally, with approximately 70% of pre-malignant breast tumors, known as ductal carcinoma in situ (DCIS), and 20% invasive tumors overexpressing human epidermal growth factor receptor 2 (HER2). While biological role HER2 has been extensively studied, its impact on stem cells (BCSCs) early-stage tumorigenesis, particularly within tumor microenvironment, remains unclear. Here, we explore overexpression driving cellular events microenvironment during...
SUMMARY HER2 is considered as a driver oncogene responsible for the HER2+ subtype of breast cancer. However, it still unclear how induces oncogenic transformation cancer stem cells (BCSCs) and initiates tumorigenesis during premalignant stage Here, we used clinical samples mouse models to demonstrate that neither BCSCs nor their cell-of-origin express HER2/Neu in early-stage tumors. Instead, our results Neu overexpression non-cell-autonomous manner via triggering DNA damage somatic...
Prenatal diagnosis of congenital heart disease (CHD) is quoted as 23% overall, with major centres achieving higher detection rates (DR), approaching 75%. To compare the effect on DR at our obstetric unit over an 8-year period following training in “5 Transverse View protocol”. From January 1997 to December 2004, 34 332 consecutive pregnant women underwent routine anomaly scan from 20 weeks gestational age, by sonographers different degrees experience ultrasound. The four-chamber view was...