A5088544930- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Cancer, Hypoxia, and Metabolism
- High Temperature Alloys and Creep
- Complement system in diseases
- Gene expression and cancer classification
- Biochemical and Molecular Research
- Protein Degradation and Inhibitors
- PI3K/AKT/mTOR signaling in cancer
- Fungal and yeast genetics research
- Autophagy in Disease and Therapy
- Material Properties and Failure Mechanisms
- Carcinogens and Genotoxicity Assessment
- Telomeres, Telomerase, and Senescence
- Endoplasmic Reticulum Stress and Disease
- Cellular transport and secretion
- Microtubule and mitosis dynamics
- Biological Research and Disease Studies
- Metabolism, Diabetes, and Cancer
- Neuroendocrine Tumor Research Advances
- Mechanical Failure Analysis and Simulation
- Genetics, Bioinformatics, and Biomedical Research
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Renal Diseases and Glomerulopathies
IFOM
2010-2024
Mario Negri Institute for Pharmacological Research
2019
Yancheng Institute of Technology
2012
The mTOR inhibitor everolimus is effective against advanced pancreatic neuroendocrine tumors (pNETs). However, it can cause metabolic adverse events, such as hyperglycemia, hypertriglyceridemia and hypercholesterolemia. In this work we aimed at evaluating the impact of systemic tumor lipid metabolism on efficacy. We carried out a monocentric, retrospective study to correlate plasma triglyceride cholesterol levels with progression free survival (PFS) pNET patients treated everolimus. formalin...
Abstract The DNA damage response (DDR) coordinates metabolism with nuclear and non-nuclear processes. DDR kinase Rad53 CHK1/CHK2 controls histone degradation to assist repair. However, deficiency causes histone-dependent growth defects in the absence of damage, pointing out unknown physiological functions Rad53-histone axis. Here we show that dosage control by ensures metabolic homeostasis. Under conditions, regulates levels through inhibitory phosphorylation transcription factor Spt21 NPAT...
Survival from UV-induced DNA lesions relies on nucleotide excision repair (NER) and the Mec1
Abstract This paper is inspired by a series of failures that occurred in steam drums and deareators power generation chemical/petrochemical plants. In each case the failure non-Post Weld Heat Treated (PWHT) carbon steel (CS) low alloy (LAS) welded joints was related to synergic action mechanical stresses chemical environment (boiler feed water). Although technical literature has already covered discussed topic Users have experienced such damage for long time, primary mechanism root causes...
Abstract Platinum-based drugs are largely used in cancer treatment. Using genome-wide approaches we aimed at identifying cisplatin primary and secondary targets characterizing responsive genes. The yeast Saccharomyces cerevisiae is widely to study a variety of eukaryotic cellular processes including those that relevant for human health. Yeast can be genetic, genomic mechanistic studies as well pharmacogenomic approaches. yeast-based screens identified novel genes the response. In particular,...
Abstract Introduction: Pharmacogenomics deals with inherited differences in the response to drugs. Genomic information may allow more accurate prediction of an individual's drug and selection appropriate dosage. Information for Phase I trial are limited define maximum tolerated dose toxicity To optimize objectives trials we decide propose concomitant screenings anticancer drugs on yeast. Methods: Our pharmacogenomic tool uses yeast as first step identitfy gene(s) that potentially affect(s)...