A5032704522- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Nanomaterials and Printing Technologies
- Phagocytosis and Immune Regulation
- Epigenetics and DNA Methylation
- Sphingolipid Metabolism and Signaling
- vaccines and immunoinformatics approaches
- Advanced Sensor and Energy Harvesting Materials
- MicroRNA in disease regulation
- Bladder and Urothelial Cancer Treatments
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Nanofabrication and Lithography Techniques
University of Rochester
2025
Shanghai University of Engineering Science
2024
Soochow University
2023-2024
Viva Biotech (China)
2014
B lymphocytes are essential mediators of humoral immunity and play multiple roles in human cancer. To decode the functions tumor-infiltrating cells, we generated a cell blueprint encompassing single-cell transcriptome, cell-receptor repertoire, chromatin accessibility data across 20 different cancer types (477 samples, 269 patients). cells harbored extraordinary heterogeneity comprised 15 subsets, which could be grouped into two independent developmental paths (extrafollicular versus...
Chemoresistance hinders the curative cancer chemotherapy. To define role of DNA methylation-regulated microRNA (miR) genes in chemoresistance bladder cancer, we performed both methylomic and miRomic analyses a multi-chemosensitive (5637) versus multi-chemoresistant (H-bc) cell line found that miR-193a-3p is hypermethylated/silenced 5637 hypomethylated/expressed H-bc cells. A forced reversal its level turned around cultured cells tumor xenografts nude mice. Three targets: SRSF2, PLAU HIC2,...
Abstract Ferroptosis, a newly discovered form of regulated cell death, has been reported to be associated with multiple cancers, including colorectal cancer (CRC). However, the underlying molecular mechanism is still unclear. In this study, we identified B7H3 as potential regulator ferroptosis resistance in CRC. knockdown decreased but overexpression increased CRC cells, evidenced by expression ferroptosis‐associated genes ( PTGS2 , FTL FTH and GPX4 ) levels important indicators...
Microscale heating platforms capable of generating localized temperature rises can find applications in wide‐ranging areas including nanomaterials synthesis and microscale thermometry. Here, commercially available optical calibration samples called Ronchi rulings, which consist an array chrome lines on a float glass substrate, are demonstrated to serve as reconfigurable Joule heaters. Electrical connections formed by wire bonding onto the heat individual monitor their using electrical...
Neutralizing antibodies (nAbs) play an important role against SARS-CoV-2 infections. Previously, we have reported one potent receptor binding domain (RBD)-binding nAb Ab08 the prototype and a panel of variants, but showed much less efficacy variants harboring L452R mutation. To overcome antibody escape caused by mutation, generated several structure-based derivatives. One derivative, Ab08-K99E, displayed mostly enhanced neutralizing potency Delta pseudovirus bearing mutation compared to...
Longevity Assurance 5 (LASS5), a member of the LASS/Ceramide Synthases family, synthesizes C16-ceramide and is implicated in tumor biology. However, its precise role not yet well understood. A yeast two-hybrid screen was performed using human cDNA library to identify potential LASS5- interaction partners. One identified clone encodes succinate dehydrogenase subunit B (SDHB). Mammalian assays showed that LASS5 interacts with SDHB, result also confirmed by GST pull-down coimmunoprecipitation...