A5092800310- RNA and protein synthesis mechanisms
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- Immune cells in cancer
- Chemical Synthesis and Analysis
- Sphingolipid Metabolism and Signaling
Vrije Universiteit Amsterdam
2023-2024
The G protein–coupled receptor (GPCR) US28 encoded by the human cytomegalovirus (HCMV) is associated with accelerated progression of glioblastomas, aggressive brain tumors a generally poor prognosis. Here, we showed that increased malignancy U251 glioblastoma cells enhancing signaling mediated sphingosine-1-phosphate (S1P), bioactive lipid stimulates oncogenic pathways in glioblastoma. expression abundance key components S1P axis, including an enzyme generates [sphingosine kinase 1 (SK1)],...
Abstract Messenger RNA (mRNA) display is being increasingly adopted for peptide drug candidate discovery. While many conditions have been reported the affinity enrichment step and in some cases modification, there still limited understanding about versatility of peptide–puromycin–mRNA/cDNA (complementary DNA) complexes. This work explores chemical stability mRNA/cDNA hybrid complexes under a range different fundamental as well with modification an mRNA setting. We further compare full...
Messenger RNA (mRNA) display is being increasingly adopted for peptide drug candidate discovery. While many conditions have been reported the affinity enrichment step and in some cases modification, there still limited understanding about versatility of peptide—puromycin—mRNA/cDNA (complementary DNA) complexes. This work explores chemical stability mRNA/cDNA hybrid complexes under a range different fundamental as well with modification an mRNA setting. We further compare full originating...