Antibacterial Activity of Some Non-steroidal Anti-inflammatory Drugs against Bacteria Causing Urinary Tract Infection

• DOI: 10.12691/ajidm-5-1-4
• Publication Date: 2017-03-10
• Authors: Eman Farouk Ahmed; Rehab Mahmoud Abd...; Abo Bakr F. Ahmed; Nancy Gamil Waly; Gamal Fadl Mahmou...
• Keywords: Enterococcus faecalis; Cefixime

This study aims to evaluate the effect of NSAIDs on activity some antibiotics against urinary tract pathogens. Urine samples were collected and cultured cysteine lactose electrolyte deficient (CLED) media MICs for determined using Agar dilution method. The combined effects β-lactam tested standard strains by checkerboard technique. Out 100 (63 female patients 37 male suffering from UTIs), 122 bacterial isolated. E. coli Coagulase negative Staphylococci (CoNS) most common (39.3% 26.2%, respectively), followed S. aureus (9.8%), Klebsiella spp, Enterococcus faecalis (7.4% each), P. aeruginosa (3.2%), Streptococci, Proteus spp. (2.5% each) Bacillus (1.6%). Most showed high resistance antibiotics. Diclofenac sodium indomethacin lowest MIC90 strains. All significantly lowered bacteria FICIs these combinations ranged 0.004 0.5. In conclusion, increased therapeutic showing good synergistic effect.