Conventional ultrasound combined with contrast-enhanced ultrasound predicts lateral lymph node metastasis in papillary thyroid carcinoma.

• DOI: 10.3233/ch-242217
• Publication Date: 2025-01-01
• Authors: Jing Lü; Xiaofeng Wu; Wei Wang; Zhiming Chen; Chenyang Jin; Dan Zhao; Kairen Zhang; Fenglin Dong
• Keywords: Contrast-enhanced ultrasound

This study aimed to investigate the correlation between conventional ultrasound and contrast-enhanced (CEUS) features lateral lymph node metastasis (LLNM) in papillary thyroid carcinoma (PTC), establish a predictive model, provide imaging evidence for clinical diagnosis treatment. selected 428 patients with postoperative pathologically confirmed PTC, who had undergone cervical dissection, from September 2020 August 2021 at First Affiliated Hospital of Soochow University. According pathological results, were divided into those LLNM (n = 94) without 334). The characteristics CEUS two groups retrospectively analyzed, differences them compared. Independent risk factors related screened, prediction model was constructed, its efficiency practicality evaluated. independent nodules located upper (odds ratio [OR] 2.640, 95% confidence interval [CI]: 1.488-4.682), maximum tumor diameter≥1.0 cm (OR 2.027, CI: 1.146-3.586), microcalcification 2.176, 1.153-4.106), central 3.091, 1.721-5.549), enhanced late hyperenhancement 2.440, 1.081-5.508), membrane continuity interruption early enhancement 3.988, 2.315-6.871) (P < 0.05 all). sensitivity specificity combined index predicting PTC 72.34% 78.74%, respectively (best cut-off value: 0.511); area under curve (AUC) 0.818 (95% 0.778-0.853). Moreover, AUC greater than that alone. calibration nomogram constructed based on aforementioned six showed could fit actual probability well high calibration. Decision analysis revealed has good applicability. by can effectively predict metastasis, providing an intuitive guide tool