Malignant progression and survival analysis for intraductal papillary mucinous neoplasms based on risk stratification

• DOI: 10.3760/cma.j.issn.1007-5232.2017.12.005
• Publication Date: 2017-12-20
• Authors: Shanshan Shen; Xuetian Qian; Xinghui Liu; Mengyue Shi; Yuanyuan Yu; Shuang Nie; Chunyan Peng; Bo Hyun Kong; Lei Wang; Xiaoping Zou
• Keywords: Guideline; Risk Stratification

Objective To evaluate the potential malignancy, prognosis and risk factors for intraductal papillary mucinous neoplasm (IPMN), which were classified into different levels based on Fukuoka guideline.

Methods A retrospective analysis of patients with IPMN diagnosed at Nanjing Drum Tower Hospital from 2009 to 2016 was conducted. Clinical characteristics, treatment IPMNs analyzed.

Results A total 94 included divided 3 groups according guideline, 46 in high-risk(HR) group, 30 group worrisome features (WF), 18 low-risk(LR) group. For undergoing surgery treatment, there 5 cases (19.2%, 5/26) HR 2 (12.5%, 2/16) WF whose postoperative pathological findings malignant (P=0.690). The 5-year survival rates after operations 73.9% 77.0% respectively (P=0.830). without a follow-up, 6 (33.3%, 6/18), (16.7%, 2/12) 0 (0.0%, 0/18) progressing pancreatic cancers HR, LR groups, (P<0.05). In addition, among three 49.5%, 85.7% 100.0% (P=0.025). Jaundice significantly related (P<0.01) hazard ratio 8.883 (95%CI: 2.953-26.721).

Conclusion Jaundice is predictive factor IPMN. As IPMN, should receive while those can be followed up. customized, evaluation factors, performed when needed.

Key words: Prognosis; Jaundice; Intraductal neoplasm; Risk stratification; Malignancy