A5045829230- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- Colorectal Cancer Screening and Detection
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Monoclonal and Polyclonal Antibodies Research
- Global Cancer Incidence and Screening
- Cancer Genomics and Diagnostics
- Mathematical Biology Tumor Growth
- Advanced Biosensing Techniques and Applications
- Data-Driven Disease Surveillance
- Image Retrieval and Classification Techniques
- Adolescent Sexual and Reproductive Health
- Breast Cancer Treatment Studies
- DNA Repair Mechanisms
- Diagnosis and treatment of tuberculosis
- Tuberculosis Research and Epidemiology
- Protein purification and stability
- Pancreatic and Hepatic Oncology Research
- Global Health Care Issues
- Health disparities and outcomes
- Retirement, Disability, and Employment
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
Vanderbilt University
2016-2022
CDC Foundation
2021
Pfizer (United States)
2013-2021
Vanderbilt-Ingram Cancer Center
2021
Vanderbilt University Medical Center
2021
Emory University
2018-2019
University of California, San Diego
2017
Rady Children's Hospital-San Diego
2017
National Institutes of Health Clinical Center
2011-2013
Nanotherapeutics (United States)
2013
Abstract In the United States, colorectal cancer (CRC) is fourth most common diagnosed among adults and second leading cause of death from cancer. For this guideline update, American Cancer Society (ACS) used an existing systematic evidence review CRC screening literature microsimulation modeling analyses, including a new evaluation age to begin by race sex additional that incorporates changes in US incidence. Screening with any one multiple options associated significant reduction incidence...
<h3>Context</h3>Incidence of human immunodeficiency virus (HIV) in the United States has not been directly measured. New assays that differentiate recent vs long-standing HIV infections allow improved estimation incidence.<h3>Objective</h3>To estimate incidence States.<h3>Design, Setting, and Patients</h3>Remnant diagnostic serum specimens from patients 13 years or older newly diagnosed with during 2006 22 states were tested BED HIV-1 capture enzyme immunoassay to classify as long-standing....
One third of the world's population is infected with Mycobacterium tuberculosis, and in developed countries immigration a major force that sustains incidence tuberculosis. We studied effects on epidemiology tuberculosis its recent resurgence United States.We analyzed data from national reporting system Centers for Disease Control Prevention. Since 1986 reports have included patient's country origin. Population estimates foreign-born persons were derived special samples 1980 1990 censuses.The...
Despite the long-standing observation that tuberculosis (TB) case rates are higher among racial and ethnic minorities than whites in United States (U.S.), proportion of this increased risk attributable to socioeconomic status (SES) has not been determined. Values for six SES indicators (crowding, income, poverty, public assistance, unemployment, education) were assigned U.S. TB cases reported from 1987–1993 by ZIP code- demographic-specific matching 1990 Census data. between racial/ethnic...
Burden of disease studies have been implemented in many countries using the Disability-Adjusted Life Year (DALY) to assess major health problems. Important objectives study were quantify intra-country differentials outcomes and place United States situation international context.We applied methods developed for Global Disease (GBD) data specific compute Years. Estimates are provided by age gender general population each four official race groups: White; Black; American Indian or Alaskan...
To assess the diagnostic performance of distributed human intelligence for classification polyp candidates identified with computer-aided detection (CAD) computed tomographic (CT) colonography.This study was approved by institutional Office Human Subjects Research. The requirement informed consent waived this HIPAA-compliant study. CT images from 24 patients, each at least one 6 mm or larger, were analyzed using CAD software to identify 268 candidates. Twenty knowledge workers (KWs) a...
The goal of this study is to experimentally and computationally investigate combination trastuzumab-paclitaxel therapies identify potential synergistic effects due sequencing the with in vitro imaging mathematical modeling. Longitudinal alterations cell confluence are reported for an model BT474 HER2+ breast cancer cells following various dosages timings paclitaxel trastuzumab regimens. Results drug regimens evaluated interaction relationships based on order, timing, quantity dose drugs....
There has been increasing interest in the potential association between occupation and risk of tuberculosis. Therefore, we analyzed occupational information collected on all patients with clinically active tuberculosis 29 states from 1984 to 1985. Census data were used estimate number persons each occupations. Information employment was ascertained for 9,534 (99%) working age (16 through 64 yr) patients. The overall case rate this group study areas 8.4 per 100,000 persons, which slightly...
BACKGROUND: Pooled NAT and donor screening have reduced the diagnostic window period for HIV in blood population to approximately 10 15 days. This report describes two cases of transfusion‐acquired infection verification transmission from recipients, attempts identify how 18‐year‐old acquired her infection. STUDY DESIGN AND METHODS: After a repeat had positive test result, recipients donor's previous donation were identified tested. The interviewed samples obtained DNA sequencing...
Doxorubicin forms the basis of chemotherapy regimens for several malignancies, including triple negative breast cancer (TNBC). Here, we present a coupled experimental/modeling approach to establish an in vitro pharmacokinetic/pharmacodynamic model describe how concentration and duration doxorubicin therapy shape subsequent cell population dynamics. This work features series longitudinal fluorescence microscopy experiments that characterize (1) uptake dynamics panel TNBC lines, (2) response...
Background Since the mid‐1980s, burden of liver cancer in United States has doubled, with 31,411 new cases and 24,698 deaths occurring 2014. Foreign‐born individuals may be more likely to die than general US‐born population because higher rates hepatitis B infection, a low socioeconomic position, language barriers that limit receipt early detection effective treatment. Methods To determine whether mortality were among foreign‐born versus States, population‐based data obtained from National...
While myriad molecular formats for bispecific antibodies have been examined to date, the simplest structures are often based on scFv. Issues with stability and manufacturability in scFv-based molecules, however, a significant hindrance their development, particularly high-concentration, stable formulations that allow subcutaneous delivery. Our aim was generate tetravalent molecule targeting two inflammatory mediators synergistic immune modulation. We focused an scFv-Fc-scFv format, flexible...
Abstract Purpose To develop and validate a mechanism-based, mathematical model that characterizes 9L C6 glioma cells’ temporal response to single-dose radiation therapy in vitro by explicitly incorporating time-dependent biological interactions with radiation. Methods We employed time-resolved microscopy track the confluence of cells receiving doses 0, 2, 4, 6, 8, 10, 12, 14 or 16 Gy. DNA repair kinetics are measured γH2AX expression via flow cytometry. The data (814 replicates for 9L, 540...
The Centers for Disease Control and Prevention maintains a national surveillance system that provides data about the HIV/AIDS epidemic program planning resource allocation. Until recently, incidence of HIV infection (i.e., number individuals recently infected with HIV) has not been directly measured. New serologic testing methods make it possible to distinguish between recent long-standing HIV-1 on population level. This article describes new National Incidence Surveillance System.