A5043397706- Antifungal resistance and susceptibility
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and biological activity
- Antimicrobial Peptides and Activities
- Bacterial biofilms and quorum sensing
- Synthesis and Biological Evaluation
- Antimicrobial Resistance in Staphylococcus
- Essential Oils and Antimicrobial Activity
- Cancer therapeutics and mechanisms
- Fungal Infections and Studies
- Computational Drug Discovery Methods
- Oral microbiology and periodontitis research
- Zebrafish Biomedical Research Applications
- Venomous Animal Envenomation and Studies
- Ocular Infections and Treatments
- DNA Repair Mechanisms
- Neuroscience and Neuropharmacology Research
- Antimicrobial agents and applications
- Chemistry and Chemical Engineering
- Medicinal Plants and Neuroprotection
- Bioactive Compounds and Antitumor Agents
- Curcumin's Biomedical Applications
- Insect Pest Control Strategies
- Fungal Plant Pathogen Control
- Cholinesterase and Neurodegenerative Diseases
Universidade Regional do Cariri
2023-2025
Universidade Estadual do Ceará
2018-2024
The plant Alpinia zerumbet, commonly known as "Colonia," is widely utilized in traditional medicine for addressing anxiety and hypertension, both of which are associated with oxidative damage the brain. This study aimed to explore antioxidant anticholinesterase properties essential oil extracted from its leaves. Additionally, an in-silico investigation was carried out on several constituents concerning acetylcholinesterase enzyme. GC/MS analysis identified nineteen volatile compounds, mainly...
Introduction.Candida spp. are commensal fungal pathogens of humans, but when there is an imbalance in the microbiota, or weak host immunity, these yeasts can become pathogenic, generating high medical costs.Gap Statement. With increase resistance to conventional antifungals, development new therapeutic strategies necessary. This study evaluated vitro antifungal activity chlorogenic acid against fluconazole-resistant strains Candida Mechanism action through flow cytometry and silico analyses,...
Background: Staphylococcus aureus is a human pathogen responsible for high mortality rates. The development of new antimicrobials urgent. Materials & methods: authors evaluated the activity hydralazine along with its synergism other drugs and action on biofilms. With regard to mechanisms, cell viability, DNA damage molecular docking. Results: MIC minimum bactericidal concentration values ranged from 128 2048 μg/ml. There was oxacillin (50%) vancomycin (25%). Hydralazine reduced viability...
Candida spp. infections are a serious health problem, especially in patients with risk factors. The acquisition of resistance, often associated biofilm production, makes treatment more difficult due to the reduced effectiveness available antifungals. Drug repurposing is good alternative for by biofilms. present study evaluated vitro antibiofilm activity sertraline reducing cell viability forming and matured biofilms, addition elucidating whether effective concentrations safe. Sertraline than...
This study evaluated the effect of etomidate against biofilms Candida spp. and analysed through molecular docking interaction this drug with ALS3, an important protein for fungal adhesion. Three fluconazole-resistant fungi were used: albicans, parapsilosis tropicalis. Growing exposed to at 31.25-500 µg ml-1. Then, ALS3 adhesive from C. albicans was a mapping technique, composed sequence algorithms perform simulation based on classic force field theory. Etomidate showed antifungal activity...
The species Tapirira guianensis Aubl is used in folk medicine to treat leprosy, diarrhea, and syphilis. present study aims evaluate the chemical composition antioxidant, anticholinesterase, antifungal potential of essential oil from T. leaves. plant material was collected at Arco Estadual do Cocó, with prior authorization Municipal Environment Department. extracted through hydrodistillation process a Clevenger-type apparatus, constituents were evaluated Gas Chromatography coupled Mass...
The genus Candida spp. has been highlighted as one of the main etiological agents causing fungal infections, with albicans being most prominent, responsible for cases candidemia. Due to its capacity invasion and tissue adhesion, it is associated formation biofilms, mainly in environment hospital devices, decreasing effectiveness available treatments. repositioning drugs, which characterized by use drugs already on market other purposes, together molecular-docking methods can be used aiming...
To evaluate the antibacterial activity of paroxetine alone and associated with oxacillin against isolates methicillin-sensitive -resistant
Aim: Our study evaluated the activity of sertraline (SER) alone and associated with antifungal drugs in planktonic Candida spp. strains, investigated its mechanism action. Materials & methods: Broth microdilution method minimum fungicidal concentration/MIC ratio were used to assess SER anticandidal activity, interaction antifungals was determined by fractional inhibitory concentration index. The action flow cytometry silico tests. Results: inhibited strains at low concentrations effect...
Objective: The present study investigated the antifungal action of dexamethasone disodium phosphate (Dex). Methodology: Susceptibility testing was performed using Clinical & Laboratory Standards Institute protocol; M27-A3, checkerboard test and biofilm were evaluated with two isolates Candida albicans, hyphal production test, molecular docking analysis flow cytometry analysis. Result: Dex fluconazole (FLC) together had a synergistic effect. Mature reduced when treated alone or in...
Introduction. Antibiotic resistance is a major threat to public health, particularly with methicillin-resistant Staphylococcus aureus (MRSA) being leading cause of antimicrobial resistance. To combat this problem, drug repurposing offers promising solution for the discovery new antibacterial agents.Hypothesis. Menadione exhibits activity against methicillin-sensitive and S. strains, both alone in combination oxacillin. Its primary mechanism action involves inducing oxidative...
Aim: This study was designed to evaluate the in vitro antimicrobial activity of amlodipine against Staphylococcus aureus strains. Materials & methods: The evaluated by broth microdilution method and its interaction with oxacillin checkerboard assay. possible mechanism action flow cytometry molecular docking techniques. Results: Amlodipine showed S. between 64 128 μg/ml, addition showing synergism approximately 58% strains used. also good forming mature biofilms. may be attributed ability...
Objective: To evaluate the antifungal activity of hydralazine hydrochloride alone and in synergy with azoles against Candida spp. action mechanism. Methods: We used broth microdilution assays to determine MIC, checkerboard investigate synergism, flow cytometry molecular docking tests ascertain Results: Hydralazine had range 16-128 μg/ml synergistic effect itraconazole versus 100% fungal isolates, while there was fluconazole 11.11% isolates. There interaction receptors exo-B(1,3)-glucanase...
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the main human pathogens and responsible for many diseases, ranging from skin infections to more invasive infections. These are dangerous expensive treat because these strains resistant a large number conventional antibiotics. Thus, antibacterial effect ketamine against MRSA strains, its mechanism action, in silico interaction with sortase A were evaluated. The was assessed using broth microdilution method. Subsequently, action...
Ternatina é um flavonoide que pode ser isolado da Egletes viscosa Less (Macela-da-terra), possui atividade antitrombótica na agregação plaquetária. O conhecimento estrutura tridimensional de uma molécula fundamental importância, pois a partir descritores energéticos e estruturais possível analisar interação substância com seu alvo biológico. Os métodos quânticos semi-empíricos utilizam parâmetros ajustes matemáticos para o entendimento das propriedades eletrônicas molécula, são necessários...
Atualmente, dentre os inibidores de protease HIV aprovados pela FDA, disponíveis comercialmente, destaca-se o Saquinavir, um fármaco indicado para tratamento do HIV-1 com imunodeficiência avançada, juntamente análogos nucleosídeo antirretrovirais, em que atua como inibidor da protease, atividade contra vírus humana Tipo 1 (HIV-1), ligando-se ao sítio ativo e inibindo a enzima. Derivados semissintéticos bixina vem sendo pesquisados, expectativa desenvolver fármacos, direcionados aplicações...
Abstract The xanthone lichenxanthone did not show toxic effects (LC 50 >1.0 mg/mL). prevented nociceptive behavior induced by acidic saline, and its analgesic effect was blocked amiloride, highlighting the involvement of neuromodulation acid‐sensitive ion channels (ASICs). In analysis anti‐inflammatory activity, concentrations 0.1 0.5 mg/mL reduced edema k‐carrageenan 3.5 %, observed from fourth hour analysis. This similar to that with ibuprofen (positive control). No leukocyte...
This study carried out to investigate the anti-inflammatory and antinociceptive effect of tropane alkaloid (EB7) isolated from E. bezerrae. It evaluated toxicity possible involvement ion channels in EB7, as well its adult zebrafish (Zfa). Docking studies with EB7 COX-1 2 were also performed. The tested doses (4, 20 40 mg/kg) did not show any toxic on Zfa during 96h analysis (LD50>40 mg/kg). They produce alteration locomotor behavior animals. Furthermore, showed promising pharmacological...
Aim: The purpose of this study was to assess the antifungal effect β-lapachone (β-lap) on azole-resistant strains Candida spp. in both planktonic and biofilm form. Materials & methods: activity β-lap evaluated by broth microdilution, flow cytometry comet assay. cell viability biofilms assessed using MTT Results: showed against resistant In addition, decreased mature inhibited formation vitro. Conclusion: spp., suggesting that compound can be utilized as an adjunct agent treatment candidiasis.