A5022970869- Antifungal resistance and susceptibility
- Essential Oils and Antimicrobial Activity
- Phenothiazines and Benzothiazines Synthesis and Activities
- Bacterial biofilms and quorum sensing
- Fungal Infections and Studies
- Antimicrobial agents and applications
- Synthesis and biological activity
- Antibiotic Resistance in Bacteria
- Antimicrobial Peptides and Activities
- Piperaceae Chemical and Biological Studies
- Bioactive Compounds and Antitumor Agents
- Antimicrobial Resistance in Staphylococcus
- Natural product bioactivities and synthesis
- Probiotics and Fermented Foods
- Antibiotics Pharmacokinetics and Efficacy
- Herbal Medicine Research Studies
- Nail Diseases and Treatments
- Nosocomial Infections in ICU
- Oral microbiology and periodontitis research
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Cancer, Stress, Anesthesia, and Immune Response
- Ocular Infections and Treatments
- Free Radicals and Antioxidants
- Phytochemistry Medicinal Plant Applications
Universidade Federal do Ceará
2016-2025
State University of Vale do Acaraú
2023
Unichristus
2017-2018
National Nuclear Energy Commission
2010
ABSTRACT Flavonoids are a class of phenolic compounds commonly found in fruits, vegetables, grains, flowers, tea, and wine. They differ their chemical structures characteristics. Such show various biological functions have antioxidant, antimicrobial, anti-inflammatory, antiapoptotic properties. The aim this study was to evaluate the vitro interactions flavonoids with fluconazole against Candida tropicalis strains resistant fluconazole, investigating mechanism synergism. Three combinations...
The incidence of fungal infections and, in particular, the antibiotic resistance, which is associated with biofilm formation, have significantly increased, contributing to morbidity and mortality. Thus, new therapeutic strategies need be developed. In this context, natural products emerged as a major source possible antifungal agents. Berberine protoberberine-type isoquinoline alkaloid isolated from roots, rhizomes, stem bark herbs, such Berberis aquifolium, vulgaris, aristata, Hydrastis...
In recent decades, the incidence of candidemia in tertiary hospitals worldwide has substantially increased. These infections are a major cause morbidity and mortality; addition, they prolong hospital stays raise costs associated with treatment. Studies have reported significant increase by non-albicans Candida species, especially C. tropicalis. The number antifungal drugs on market is small comparison to antibacterial agents available. limited treatment options, coupled increasing frequency...
ABSTRACT There have recently been significant increases in the prevalence of systemic invasive fungal infections. However, number antifungal drugs on market is limited comparison to available antibacterial drugs. This fact, coupled with increased frequency cross-resistance, makes it necessary develop new therapeutic strategies. Combination drug therapies become one most widely used and effective strategies alleviate this problem. Amiodarone (AMD) classically for treatment atrial fibrillation...
Recent research has shown broad antifungal activity of the classic antidepressants selective serotonin reuptake inhibitors (SSRIs). This fact, combined with increased cross-resistance frequency genre Candida regarding main treatment today, fluconazole, requires development novel therapeutic strategies. In that context, this study aimed to assess potential fluoxetine, sertraline, and paroxetine against fluconazole-resistant spp. planktonic cells, as well mechanism action viability biofilms...
Background/Objectives: Mixed bloodstream infections associated with central venous catheter (CVC) use are a growing problem. The aim of this study was to evaluate the activity cationic arginine-based gemini surfactant, C9(LA)2, against mixed biofilms fluconazole-resistant Candida albicans and extended-spectrum beta-lactamase (ESBL)-producing E. coli, preventive effect surfactant impregnated in CVCs on formation inter-kingdom biofilms. Methods: Broth microdilution assays were performed along...
Abstract This study aimed to characterize Melissa officinalis essential oil (EOMO) from a region in Northeast Brazil and evaluate its antifungal activity against Candida Cryptococcus neoformans, by analyzing action mechanism. EOMO was characterized using gas chromatography-mass spectrometry the main chemical compounds were Geranial (14.10%) (Z)-Nerolidol (17.75%). The broth microdilution assay used determine minimum inhibitory concentration (MIC) strains of albicans, parapsilosis, krusei,...
Urinary infections caused by Staphylococcus aureus are commonly associated with urinary catheterization and often result in severe complications. Given this problem, the objective of study was to investigate preventive action promethazine (PMT) against formation methicillin-resistant (MRSA) biofilms when impregnated catheters. For purpose, techniques such as broth microdilution, checkerboard, impregnation on catheter fragments, flow cytometry assays scanning electron microscopy were...
To synthesize and characterize a Schiff base derived from vanillin tris(hydroxymethyl)aminomethane (VTRIS) the Zinc (II) complex [Zn(VTRIS)2](CH3COO)2. VTRIS Zn were synthesized through condensation complexation reactions, respectively. Structures confirmed by electron spectroscopy in UV-Vis, FT-IR NMR regions. Toxicity was evaluated Artemia salina, antimicrobial activity microdilution assay, ABTS DPPH methods used for antioxidant effect anticholinesterase potential investigated. showed low...
Over the last decade, there has been a dramatic increase in prevalence and gravity of systemic fungal diseases. This study aimed therefore at evaluating antifungal potential ester derivatives benzoic cinnamic acids from three Candida species. The compounds were prepared via Fischer esterification, assay was performed by microdilution method 96-well microplates for determining minimal inhibitory concentrations (MICs). findings tests revealed that analogue compound methyl ferulate, o...
Introduction.Candida spp. are commensal fungal pathogens of humans, but when there is an imbalance in the microbiota, or weak host immunity, these yeasts can become pathogenic, generating high medical costs.Gap Statement. With increase resistance to conventional antifungals, development new therapeutic strategies necessary. This study evaluated vitro antifungal activity chlorogenic acid against fluconazole-resistant strains Candida Mechanism action through flow cytometry and silico analyses,...
Background: Staphylococcus aureus is a human pathogen responsible for high mortality rates. The development of new antimicrobials urgent. Materials & methods: authors evaluated the activity hydralazine along with its synergism other drugs and action on biofilms. With regard to mechanisms, cell viability, DNA damage molecular docking. Results: MIC minimum bactericidal concentration values ranged from 128 2048 μg/ml. There was oxacillin (50%) vancomycin (25%). Hydralazine reduced viability...
Dual-species biofilms formed by Candida albicans and Staphylococcus aureus have high virulence drug resistance. In this context, biosurfactants produced Pseudomonas aeruginosa been widely studied, of which a new derivative (RLmix_Arg) stands out for possible application in formulations. The objective study was to evaluate the antibiofilm activity RLmix_Arg, both alone incorporated gel prepared with Pluronic F-127, against dual-species fluconazole-resistant C. (FRCA) methicillin-resistant S....
Aim: To evaluate the antifungal activity of gallic acid (GA) against strains Candida spp. resistant to fluconazole and determine its mechanism action. Materials & methods: Antifungal was evaluated using broth microdilution flow cytometry techniques. Results: GA presented minimum inhibitory concentrations ranging from 16 72 μg/ml, causing alterations membrane integrity mitochondrial transmembrane potential, production reactive oxygen species externalization phosphatidylserine. Conclusion: has...
Candida spp. infections are a serious health problem, especially in patients with risk factors. The acquisition of resistance, often associated biofilm production, makes treatment more difficult due to the reduced effectiveness available antifungals. Drug repurposing is good alternative for by biofilms. present study evaluated vitro antibiofilm activity sertraline reducing cell viability forming and matured biofilms, addition elucidating whether effective concentrations safe. Sertraline than...
Introduction. Candida albicans and Staphylococcus aureus are recognized for their development of resistance biofilm formation. New therapeutic alternatives necessary in this context. Hypothesis. Etomidate shows potential application catheters against mixed biofilms fluconazole-resistant C. methicillin-resistant S. (MRSA). Aim. The present study aimed to evaluate the activity etomidate MRSA. Methodology. action mature was verified through evaluation biomass cell viability, its ability prevent...
This study evaluated the effect of etomidate against biofilms Candida spp. and analysed through molecular docking interaction this drug with ALS3, an important protein for fungal adhesion. Three fluconazole-resistant fungi were used: albicans, parapsilosis tropicalis. Growing exposed to at 31.25-500 µg ml-1. Then, ALS3 adhesive from C. albicans was a mapping technique, composed sequence algorithms perform simulation based on classic force field theory. Etomidate showed antifungal activity...