A5067358157- Pancreatic function and diabetes
- Congenital heart defects research
- Tracheal and airway disorders
- Genetic Syndromes and Imprinting
- Hippo pathway signaling and YAP/TAZ
- Phagocytosis and Immune Regulation
- Metabolism, Diabetes, and Cancer
- Developmental Biology and Gene Regulation
- Diabetes Treatment and Management
- 3D Printing in Biomedical Research
University of Copenhagen
2018-2023
Novo Nordisk Foundation
2018-2022
King's College London
2012-2014
The thymus and parathyroid glands are derived from the third pharyngeal pouch endoderm. mechanisms that establish distinct molecular domains in control subsequent separation of these organ primordia pharynx poorly understood. Here, we report mouse embryos lack two FGF feedback antagonists, Spry1 Spry2, display hypoplasia a failure to completely separate pharynx. We show ligands downstream reporter genes expressed highly regionalised patterns sprouty gene deletion results upregulated...
Background: The T‐box transcription factor Tbx1, is essential for the normal development of multiple organ systems in embryo. One most striking phenotypes Tbx1−/− embryos failure caudal pharyngeal pouches to evaginate from foregut endoderm. Despite considerable interest role Tbx1 development, mechanisms whereby controls pouch formation have remained elusive. In particular, question as how expression endoderm regulates morphogenesis mouse embryo not known. Results: To address this question,...
MODY3 is a monogenic hereditary form of diabetes caused by mutations in the transcription factor HNF1A. The patients progressively develop hyperglycemia due to perturbed insulin secretion, but pathogenesis unknown. Using patient-specific hiPSCs, we recapitulate secretion sensitivity membrane depolarizing agent sulfonylurea commonly observed patients. Unexpectedly, HNF1A+/R272C β cells hypersecrete both vitro and vivo after transplantation into mice. Consistently, identified trend increased...
Abstract During embryogenesis dynamic changes in tissue architecture transform primitive anlages to functional organs. Here we document real time how pancreatic lumens are derived and transformed using a new apical-polarity mouse reporter. Our 4D imaging data reveals remodeling of apical proteins primarily drive each stage duct development. Furthermore, pinpoint two unique transitions during lumenogenesis. Contrary current “ de novo ” models polarity acquisition, show that expansion...