A5004607594- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Mental Health Research Topics
- Tryptophan and brain disorders
- Digital Mental Health Interventions
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Barrier Structure and Function Studies
- Mental Health Treatment and Access
- Thermal properties of materials
- Extracellular vesicles in disease
- Neuroscience and Neuropharmacology Research
- Treatment of Major Depression
- Artificial Intelligence in Healthcare and Education
- Child Abuse and Trauma
- Neonatal and fetal brain pathology
- Birth, Development, and Health
- Neuroendocrine regulation and behavior
- Functional Brain Connectivity Studies
- Machine Learning in Healthcare
McGill University
2017-2024
Douglas Mental Health University Institute
2015-2023
Jewish General Hospital
2017
Institut Universitaire en Santé Mentale de Québec
2017
Douglas College
2017
Child abuse has devastating and long-lasting consequences, considerably increasing the lifetime risk of negative mental health outcomes such as depression suicide. Yet neurobiological processes underlying this heightened vulnerability remain poorly understood. The authors investigated hypothesis that epigenetic, transcriptomic, cellular adaptations may occur in anterior cingulate cortex a function child abuse.Postmortem brain samples from human subjects (N=78) rodent model impact early-life...
Background Recently, artificial intelligence-powered devices have been put forward as potentially powerful tools for the improvement of mental healthcare. An important question is how these impact physician-patient interaction. Aims Aifred an clinical decision support system (CDSS) treatment major depression. Here, we explore use a simulation centre environment in evaluating usability Aifred, particularly its on physician–patient Method Twenty psychiatry and family medicine attending staff...
Background: Deep learning has utility in predicting differential antidepressant treatment response among patients with major depressive disorder, yet there remains a paucity of research describing how to interpret deep models clinically or etiologically meaningful way. In this paper, we describe methods for analyzing clinical and demographic psychiatric data, using our recent work on model STAR*D CO-MED remission prediction. Methods: Our analysis yielded four that predicted the treatments...
Abstract Exposure to early life adversity (ELA) poses a significant global public health concern, with profound pathophysiological implications for affected individuals. Studies suggest that ELA contributes endothelial dysfunction, bringing into question the functional integrity of neurovascular unit in brain regions vulnerable chronic stress. Despite importance neurovasculature maintaining normal physiology, human cells remain poorly characterized, particularly regard their contributory...
The neurovascular unit, comprised of vascular cell types that collectively regulate cerebral blood flow to meet the needs coupled neurons, is paramount for proper function central nervous system. unit gatekeeps blood-brain barrier properties, which experiences impairment in several system diseases associated with neuroinflammation and contributes pathogenesis. To better understand dysfunction at how it may confer inflammatory processes within brain, isolation characterization needed. Here,...
Abstract Previous work has demonstrated that microRNAs (miRNAs) change as a function of antidepressant treatment (ADT) response. However, it is unclear how representative these peripherally detected miRNA changes are to those occurring in the brain. This study aimed use extracted neuron-derived extracellular vesicles (NDEVs) circumvent limitations and investigate neuronal associated with Samples were collected at two time points (baseline after 8 weeks follow-up) from depressed patients who...
ABSTRACT Objective Aifred is an artificial intelligence (AI)-powered clinical decision support system (CDSS) for the treatment of major depression. Here, we explore use a simulation centre environment in evaluating usability Aifred, particularly its impact on physician-patient interaction. Methods Twenty psychiatry and family medicine attending staff residents were recruited to complete 2.5-hour study at interaction with standardized patients. Each physician had option using CDSS inform...
Abstract The neurovascular unit (NVU), comprised of endothelial cells, pericytes, smooth muscle astrocytic endfeet and microglia together with neurons, is paramount for the proper function central nervous system. NVU gatekeeps blood-brain barrier (BBB) properties which, as a system, experiences impairment in several neurological psychiatric diseases, contributes to pathogenesis. To better understand dysfunction at NVU, isolation characterization needed. Here, we describe singular,...