A5071414632- Blood properties and coagulation
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Cellular Mechanics and Interactions
- Endoplasmic Reticulum Stress and Disease
- Proteins in Food Systems
- PI3K/AKT/mTOR signaling in cancer
- CRISPR and Genetic Engineering
- Fungal and yeast genetics research
- Genetics, Aging, and Longevity in Model Organisms
- Fungal Biology and Applications
Centre National de la Recherche Scientifique
2017-2023
Université de Montpellier
2017-2023
Jawaharlal Nehru University
2012-2018
Inserm
2017-2018
University of Delhi
2012
An inherited gain-of-function variant (E756del) in the mechanosensitive cationic channel PIEZO1 was shown to confer a significant protection against severe malaria. Here, we demonstrate vitro that human red blood cell (RBC) infection by Plasmodium falciparum is prevented pharmacological activation of PIEZO1. Yoda1 causes an increase intracellular calcium associated with rapid echinocytosis inhibits RBC invasion, without affecting parasite intraerythrocytic growth, division or egress....
Abstract Background Peptide: N- glycanase (PNGase) enzyme cleaves oligosaccharides from the misfolded glycoproteins and prepares them for degradation. This plays a role in endoplasmic reticulum associated degradation (ERAD) pathway yeast mice but its biological importance multicellular development remain largely unknown. Results In this study, PNGase cellular slime mold, Dictyostelium discoideum ( Dd PNGase) was identified based on presence of common TG (transglutaminase) core domain...
Sirtuins (SIRTs) belong to class III histone deacetylases and require NAD+ for their activity. Their activity is associated with the nutritional status of cell they directly link cellular metabolic signalling state protein post-translational modifications. play an important role in healthy aging, longevity age-related diseases, as well survival mechanisms, such autophagy. Here, we investigate functions Dictyostelium discoideum Sir2D which shows similarity human SIRT1. This gene expressed...
TOR (target of rapamycin) protein kinase acts as a central controller cell growth and development an organism. Present study was undertaken to find the expression pattern role during Dictyostelium discoideum. Failures generate either knockout and/or knockdown mutants indicate that interference with its levels led cellular defects. Thus, effects (DDB_G0281569) overexpression specifically, cells expressing Dd(Δ211-TOR)-Eyfp mutant analyzed. Elevated (Δ211-TOR)-Eyfp reduced both size...
Abstract Hereditary xerocytosis (HX) is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. Gain-of-function (GOF) mutations in mechanosensitive Piezo1 ion channels are identified HX patients. RBC linked reduced Plasmodium infection rates vitro. We engineered mouse model of and show that fails cause experimental cerebral malaria these mice. Furthermore, we novel GOF human variant, E756del, present third African population. Remarkably,...
Abstract An inherited gain-of–function variant (E756 del) in the mechanosensitive cationic channel PIEZO1 was recently shown to confer a significant protection against severe malaria. Here, we demonstrate vitro that human red blood cell (RBC) infection by Plasmodium falciparum is prevented pharmacological activation of PIEZO1. The activator Yoda1 inhibits RBC invasion, without affecting parasite intraerythrocytic growth, division or egress. dehydration, echinocytosis and intracellular Na +...