A5019704913- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- interferon and immune responses
- RNA Interference and Gene Delivery
- Mosquito-borne diseases and control
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- CAR-T cell therapy research
- Computational Drug Discovery Methods
- Eosinophilic Disorders and Syndromes
- Chronic Lymphocytic Leukemia Research
- Neuroblastoma Research and Treatments
- Advanced Breast Cancer Therapies
- Cytokine Signaling Pathways and Interactions
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- CRISPR and Genetic Engineering
- Synthesis and biological activity
- Sleep and Wakefulness Research
- Sleep and related disorders
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Antibiotics Pharmacokinetics and Efficacy
- Biochemical and Molecular Research
Kern Medical Center
2025
Pittsburg State University
2024
University of Pittsburgh
2024
Dana-Farber Cancer Institute
2021-2024
Boston Children's Hospital
2021-2024
Broad Institute
2023
Harvard University
2021-2022
University of Massachusetts Boston
2018-2022
University of South Dakota
2018
Nishtar Medical College and Hospital
2018
Knockdown of orexin/hypocretin 2 receptor (Orx2) in the basolateral amygdala (BLA) affects anxious and depressive behavior. We use a new behavioral paradigm, Stress Alternatives Model (SAM), designed to improve translational impact. The SAM induces social stress adult male mice by aggression from larger mice, allowing for adaptive decision-making regarding escape. In this model, remain (Stay) oval arena or escape (Escape) via routes only large enough smaller mouse. hypothesized...
Leukemic blasts are immune cells gone awry. We hypothesized that dysregulation of inflammatory pathways contributes to the maintenance their leukemic state and can be exploited as cell-intrinsic, self-directed immunotherapy. To this end, we applied genome-wide screens discover genetic vulnerabilities in acute myeloid leukemia (AML) implicated pathways. identified modulator IRF2BP2 a selective AML dependency. validated cell dependency on with protein degradation approaches vitro genetically...
Abstract Background Central nervous system (CNS) involvement with coccidioidomycosis (cocci) is a serious infection that universally fatal if not treated. Prior to the advent of magnetic resonance imaging (MRI), very few reports describe spinal cord and autopsies often omitted examination. Accurate anatomic localization areas affected by CNS cocci can be challenging due mental status changes presence brain abnormalities. Here, we radiologic clinical characteristics 53 cases who had MRI...
Abstract Aberrant RAS/MAPK signaling is a common driver of oncogenesis that can be therapeutically targeted with clinically approved MEK inhibitors. Disease progression on single-agent inhibitors common, however, and combination therapies are typically required to achieve significant clinical benefit in advanced cancers. Here we focused identifying inhibitor-based neuroblastoma mutations activate the pathway, which rare at diagnosis but frequent relapsed neuroblastoma. A genome-scale...
Abstract Tissue-specific differences in the expression of paralog genes, which are not essential most cell types due to buffering effect partner pair, can make for highly selective gene dependencies. To identify paralogous targets acute myeloid leukemia (AML), we integrated Cancer Dependency Map with numerous datasets characterizing protein–protein interactions, relationships, and cancer models. In this study, identified ATP1B3 as a context-specific, paralog-related dependency AML. ATP1B3,...
Abstract Purpose: Patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) lymphoma (T-LBL) have limited therapeutic options. Clinical use of genomic profiling provides an opportunity to identify targetable alterations inform therapy. Experimental Design: We describe a cohort 14 pediatric patients T-ALL enrolled on the Leukemia Precision-based Therapy (LEAP) Consortium trial (NCT02670525) and patient T-LBL, discovering in platelet-derived growth factor receptor-α...
<p>KO validation using TIDE PCR and cell cycle analysis</p>
<p>Cell viability assay in OCI-AML3 CTRL and TP53-KO cells treated with Nutlin-3.</p>
<p>Candidate gene selection based on the introduced features</p>
<p>Isoform expression of ATP1B1</p>
<p>GSEA enrichments for the most significant biological processes Gene Ontology terms in ATP1B1 dependent and not cell lines</p>
<p>In vivo data and validation of MV4-11_LUC cell models</p>
<p>NB4_BioID results</p>
<p>ATP1B1 expression in CCLE and Treehouse data base</p>
<p>Merged file_supplementary figures and tables with legend</p>
<p>ATP1B1 expression in CCLE highlighting Ewing sarcoma cell lines</p>
<div>Abstract<p>Tissue-specific differences in the expression of paralog genes, which are not essential most cell types due to buffering effect partner pair, can make for highly selective gene dependencies. To identify paralogous targets acute myeloid leukemia (AML), we integrated Cancer Dependency Map with numerous datasets characterizing protein–protein interactions, relationships, and cancer models. In this study, identified ATP1B3 as a context-specific, paralog-related...
<p>ATP1B1 expression across hematopoietic lineages</p>