A5073415982- Traumatic Brain Injury and Neurovascular Disturbances
- Moyamoya disease diagnosis and treatment
- S100 Proteins and Annexins
- Intracerebral and Subarachnoid Hemorrhage Research
- Immune Response and Inflammation
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Molecular Biology Techniques and Applications
- Neonatal and fetal brain pathology
- Glioma Diagnosis and Treatment
- Neurological Complications and Syndromes
- Cerebrospinal fluid and hydrocephalus
- Virus-based gene therapy research
- Cytokine Signaling Pathways and Interactions
- Viral gastroenteritis research and epidemiology
- RNA modifications and cancer
- Advanced Glycation End Products research
- Neuroinflammation and Neurodegeneration Mechanisms
- Thermal Regulation in Medicine
- PARP inhibition in cancer therapy
- Neurosurgical Procedures and Complications
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Kruppel-like factors research
- Cerebrovascular and genetic disorders
Nanjing Brain Hospital
2014-2025
Nanjing Medical University
2013-2025
Nanyang Normal University
2024
University of Michigan
2014-2016
Nanjing University
2011-2013
Nanjing General Hospital of Nanjing Military Command
2011-2013
Ethyl pyruvate (EP) has demonstrated neuroprotective effects against acute brain injury through its anti-inflammatory action. The nuclear protein high-mobility group box 1 (HMGB1) can activate inflammatory pathways when released from dying cells. This study was designed to investigate the protective of EP secondary in rats after Traumatic Brain Injury (TBI). Adult male were randomly divided into three groups: (1) Sham + vehicle group, (2) TBI and (3) (<mml:math...
Microplastic (MP) are an emerging environmental pollutant, which has toxic effects on organisms, and it received extensive attention currently. Studying the transcriptomic metabolic responses of mice to nanoplastic-contaminated water is critical for understanding molecular-level toxicity nanoplastics (NPs), but there few studies this topic. To analyze different concentrations polystyrene (PS) at transcriptome metabolism spleens study molecular toxicity. Here, testing histopathology spleen...
Background: Ischemic stroke is one of the major emergency diseases leading to death and disability worldwide, characterized by its acute onset urgent need for prompt medical intervention reduce mortality long‐term disability. Chronic terminal internal carotid artery and/or middle cerebral occlusion (CTI/MCAO) an important subtype intracranial occlusive disease. The superficial temporal artery‐to‐MCA (STA‐MCA) bypass has been proposed improve blood flow (CBF) cerebrovascular reserve (CVR),...
The present retrospective study was performed to evaluate the clinical outcome, as well post-operative collateral formation and revascularization patterns in combined bypass. Surgical has been mainstay of treatment for moyamoya patients. A total 76 hemispheres from 64 patients undergoing superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis encephalo-duro-myo-synangiosis (EDMS) were retrospectively reviewed. Computed tomography perfusion DSA routinely performed. Modified...
(1) Goose astrovirus (GAstV) is a novel emerging pathogen that causes significant economic losses in waterfowl farming. A convenient, sensitive, and specific detection method for GAstV field samples important order to effectively control GAstV. Droplet digital polymerase chain reaction (ddPCR) novel, good-precision, absolute quantitation PCR technology which does not require calibration curves. (2) In this study, we developed ddPCR system the sensitive accurate quantification of using...
The Ras-related C3 botulinum toxin substrate 1 (Rac1)-WASP-family verprolin-homologous protein-2 (WAVE2)-actin-related protein 2/3 (Arp2/3) signaling pathway has been identified to be involved in cell migration and invasion various types of cancer cell. Cofilin‑1 (CFL‑1), which is regulated by the Rac1‑WAVE2‑Arp2/3 pathway, may promote radioresistance glioma. Therefore, present study aimed investigate potential role U251 human glioma cells elucidate its affect on CFL‑1 expression. Western...
Inflammatory responses are correlated with secondary brain injury after aneurysmal subarachnoid hemorrhage (aSAH). Galectin-3 (Gal-3) is a novel biomarker reflecting inflammation status, and its elevated circulating levels associated poor prognosis of some inflammatory diseases. The aim this study was to evaluate the relationship between Gal-3 plasma in group aSAH patients.We assessed 120 patients healthy individuals. 6-month clinical outcomes included mortality unfavorable outcome (Glasgow...
Goose astrovirus (GAstV) is a newly discovered astrovirus. GAstV causes gout and death in 4- to -16-day-old goslings. For the past few years, fatal gout, cardinal clinical symptom of gosling infected with GAstV, has been spreading rapidly some goose Chinese farms, which caused continuous economic losses breeding industry China. Currently, several underlying mechanisms involved viral replication, inflammatory reaction, virions release, pathogenesis remain be elucidated. In this study, we...
Background JAK2/STAT3 pathway was reported to play an essential role in the neointima formation after vascular intima injury. However, little is known regarding this whole layer injury end-to-end arterial anastomosis (AA). Here, we investigated of common carotid (CCA) anastomosis-induced cell proliferation, phenotypic change smooth muscle cells (VSMCs) and re-endothelialization. Methods CCAs adult male Wistar rats were resected at 3, 7, 14, 30 days CCA anastomosis. Activation detected by...
Background Caveolin-1 (Cav-1) plays pivotal roles in the endothelial function and angiogenesis postischemia. Moyamoya disease (MMD) is characterized by progressive artery stenosis with unknown etiology. We aim to determine whether serum Cav-1 levels of patients MMD were associated collateral vessel formation after bypass surgery. Methods studied 130 (16 RNF213 p.R4810K mutation 114 without mutation), 15 acute stroke, 33 healthy controls. Cerebral perfusion circulation evaluated preoperation...
Ventriculoperitoneal shunt is a routinely performed treatment in neurosurgical department. Intracerebral hemorrhage, as complication after catheterization, really rare but with high mortality. In this study, we reported case of 74-year-old man who suffered from repeated intracerebral hemorrhage ventriculoperitoneal shunt. The first happened 63 h the 1st surgery, and most hematomas were located ipsilateral occipital lobe intraventricles, along ventricular catheter. Fresh blood clot casts...