A5064752692- Radiopharmaceutical Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Medical Imaging Techniques and Applications
- Air Quality and Health Impacts
- Intraperitoneal and Appendiceal Malignancies
- Radioactive Decay and Measurement Techniques
- Ion Transport and Channel Regulation
- Chemotherapy-induced organ toxicity mitigation
- Field-Flow Fractionation Techniques
- Advanced Polymer Synthesis and Characterization
- Lysosomal Storage Disorders Research
- Heavy Metal Exposure and Toxicity
- Cardiac Arrest and Resuscitation
- Hepatocellular Carcinoma Treatment and Prognosis
- Nanoparticles: synthesis and applications
- Peptidase Inhibition and Analysis
- Molecular Biology Techniques and Applications
- Trypanosoma species research and implications
- Cardiac electrophysiology and arrhythmias
- Acute Kidney Injury Research
- Advanced Drug Delivery Systems
- Synthesis and Biological Evaluation
- Chemotherapy-induced cardiotoxicity and mitigation
University of Buenos Aires
2013-2024
The aim of the present work was to evaluate potential protective effect histamine on Doxorubicin (Dox)-induced hepatic and cardiac toxicity in different rodent species a triple-negative breast tumor-bearing mice model. Male Sprague Dawley rats Balb/c were divided into four groups: control (received saline), (5 mg/kg for 1 mice, daily subcutaneous injection starting 24 h before treatment with Dox), Dox (2 mg/kg, intraperitoneally injected three times week 2 weeks) Dox+histamine both...
Previous studies employing polymeric micelles and molecular imaging for in vivo nanosystem characterization have led to the development of radionanoprobes (RNPs) designed diagnosing monitoring therapeutic interventions preclinical oncology research, specifically within breast colon cancer models. These models exhibit high GLUT1 expression on tumor cells VEGFR vasculature. We aimed enhance tumor-targeting specificity these RNPs by functionalizing with glucose bevacizumab. The choice 99mTc...
D- α -Tocopheryl polyethylene glycol 1000 succinate (TPGS) is a Food and Drug Administration (FDA) approved biomaterial that can form nanosized micelles in aqueous solution. TPGS stand as an interesting system to perform drug delivery they carry lipophilic drugs overcome P glycoprotein efflux well. Therefore, combined with other copolymers have been reported many cancer research studies carrier for therapeutic drugs. Their ability reach tumoral tissue also be exploited develop imaging agents...
Abstract Major Intrinsic Proteins (MIPs) are membrane channels that permeate water and other small solutes. Some trypanosomatid MIPs mediate the uptake of antiparasitic compounds, placing them as potential drug targets. However, a thorough study diversity these is still missing. Here we place in sequence-function space large MIP superfamily through sequence similarity network. This analysis exposes aquaporins integrate distant cluster from currently defined families, here named aquaporin X...
<title>Abstract</title> Background Previous studies with polymeric micelles using molecular imaging for the <italic>in vivo</italic> study and nanosystem characterization leads us to develop radionanoprobes diagnosis monitoring of interventions in preclinical research animal models breast colon cancer. Considering possibility translation clinic, choice <sup>99m</sup>Tc label nanoprobes is its availability widespread SPECT distribution region. From radiochemical point view, a direct labeling...
Chemotherapy is one of the most common approaches for cancer treatment. Particularly Doxorubicin has been proven to be effective in treatment many soft and solid tumors locally advanced metastatic cancer. It not easy clinically evaluate chemotoxic or chemoprotective effect some drugs, even more when there a subclinical toxicity.To determine usefulness hepatobiliary, colloid cardiac scintigraphies, employing99mTcdisida, 99mTc-phytate 99mTc-sestamibi respectively, evaluation hepato...