There is increasing resistance of malaria parasites to chloroquine, the cheapest and commonly used drug for in Nigeria. Artemisin, a product from medicinal plant indigenous China, based on active principle Artemisia annua, has been introduced into Nigerian market. However not much done project antimalaria properties plants. This study thus, main objective presenting plants therapy Okeigbo, Ondo State, South west Focus group discussions interview were held about often found useful community....

Acinetobacter baumannii is one of the most notorious hospital-acquired pathogens, and novel treatment strategies are desperately required. Two-component regulatory systems represent potential therapeutic targets as they mediate microorganism adaptation to changing environments, often control virulence, specific bacteria. Here we describe first global virulence regulator in A. baumannii.Using transcriptional profiling functional assays a deletion mutant sensor kinase gene, A1S_0574 (termed...

Steam distillation of the dry flower buds Syzigium aromaticum (clove) yielded 7% (w/w) pure light yellow oil. Gas chromatography-mass spectrometry (GC-MS) analysis oil revealed that components were eugenol, caryophyllene, eugenol acetate and alpha-humelene, with being main component. The antimicrobial sensitivity volatile against some Gram-negative bacteria (Escherichia coli ATCC 35218, Escherichia coli, Klebsiella pneumoniae, Salmonella paratyphi, Citrobacter spp. Enterobacter cloacae), a...

Background Food-borne nematodes of the genus Anisakis are responsible for a wide range illnesses (= anisakiasis), from self-limiting gastrointestinal forms to severe systemic allergic reactions, which often misdiagnosed and under-reported. In order enhance refine current diagnostic tools anisakiasis, knowledge whole spectrum parasite molecules transcribed expressed by this parasite, including those acting as potential allergens, is necessary. Methodology/Principal Findings study, we employ...

ABSTRACT Over a 9-month period, 8 of 40 nonduplicate isolates Enterobacter spp. producing extended-spectrum β-lactamase (ESBL) were detected for the first time from two hospitals in Lagos, Nigeria. Microbiologic and molecular analysis confirmed presence ESBL. Only four transferred ESBL resistance as determined by conjugation test, pulsed-field gel electrophoresis showed genetically unrelated isolates.

To investigate the in-vitro antimicrobial activities of extracts Abrus precatorius on some clinical isolates as resistance to available and affordable antibiotics by these pathogens is increase.In this study effects from leaves, stem seed oil were tested against Staphylococcus aureus ATCC 25923, three S. different sources, epidermidis, Enterococcus faecalis, Streptococcus anginosus (S.milleri), Bacillus subtilis, Corynebacterium spp (toxigenic strain mitis biotype), Escherichia coli 25922,...

Two hundred and seventy three isolates of Escherichia coli obtained from 7 hospitals in Lagos were screened for Fluoroquinolone resistance (FQR). Rate was 22.3% showing an increase quinolone when compared with resistant rates between 1994 1999 which ranged 0 – 2% then. In this study FQR E. more common patients urinary tract infection (22.9%). ESBL enzyme production found to be associated most the strains. The prevalence colii faeces healthy adults 22.9%, 6.7% children 22.2% avian. By Pulsed...

The volatile oil of tangerine fruit (Citrus reticulata) was extracted by steam distillation and assessed for antibacterial antioxidant activity. tested against some Gram-negative organisms (Escherichia coli ATCC 35218, E. coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella paratyphi, Proteus mirabilis Citrobacter spp); Gram-positive such as Staphylococcus aureus 25923, S. aureus, Enterococcus faecalis a fungus (Candida albicans). minimum inhibitory concentration (MIC) determined...

Using removable silica templates, protein nanocapsules comprising the A subunit of Helicobacter pylori urease (UreA) were synthesised. The templates two sizes, with solid core mesoporous shell (SC/MS) giving rise to average diameter 510 nm and (MS) 47 nm. Both shown be highly monodispersed relatively homogenous in structure. Various combinations formulation assessed as vaccines a mouse model H. infection. Immune responses evaluated protective efficacy assessed. It was demonstrated that...

Objectives: To investigate the occurrence of Extended-Spectrum Beta-Lactamase (ESBL) enzymes in isolates Klebsiella spp and E.coli from various health institutions Lagos. Methods: From December 2000 to October 2001, 356 (200) Escherichia coli (156) were investigated for ESBL production. These obtained Microbiology laboratories 7 hospitals Lagos metropolis. Results: Seventy four (20.8%) found be ESBL-producers using double-disk test (DD test). Amongst ESBL-producers, pneumoniae (60.8%) was...

Blood culture was performed on 204 children (aged 1 day – 12 years) who presented at the University College Hospital (UCH) Ibadan, Nigeria, with fever. Eighty-four (41.3%) out of blood cultures were positive. Staphylococcus aureus commonest bacterial agent isolated and accounted for (50%) all isolates. Klebsiella spp Salmonella each 21.4% 10.7% respectively. Other agents included Escherichia coli, Enterobacter spp. Citrobacter Pseudomonas aeruginosa, Streptococcus Pneumoniae Serratia Two...

This paper sets to differentiate between Klebsiella and Enterobacter spp. Identification compare their antimicrobial susceptibility patterns at Lagos University Teaching hospital, a tertiary health institution. From March July 1998, total of 300 clinical specimens were processed in the Medical Microbiology Laboratory Hospital (LUTH). Isolates obtained from urine swabs wounds, ear, throat eye. was carried out by conventional methods investigated disk diffusion method. All isolates tested for...

Background: Bacteria infections associated with multidrug resistance have been implicated in the high mortality and morbidity, reported amongst cancer patients. This study determined beta-lactamase mediated Gram-negative bacteria isolates from patients attending Radiology Oncology Clinic of Lagos University Teaching Hospital between April November, 2006. Methods: One hundred nineteen samples were analysed characterized using analytical profile index (API) test. Antimicrobial susceptibility...