A5039588867- Bioinformatics and Genomic Networks
- Ovarian cancer diagnosis and treatment
- CRISPR and Genetic Engineering
- Genetics, Bioinformatics, and Biomedical Research
- Sinusitis and nasal conditions
- Long-Term Effects of COVID-19
- 14-3-3 protein interactions
- Gene Regulatory Network Analysis
- Vestibular and auditory disorders
- Protein Degradation and Inhibitors
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Surgical Treatments
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Head and Neck Surgical Oncology
- Computational Drug Discovery Methods
- Hearing, Cochlea, Tinnitus, Genetics
- Minimally Invasive Surgical Techniques
- Inflammasome and immune disorders
- Single-cell and spatial transcriptomics
- Hearing Loss and Rehabilitation
- COVID-19 Clinical Research Studies
- BRCA gene mutations in cancer
- Advanced biosensing and bioanalysis techniques
San Bernardino County Department of Public Health
2022
Kaiser Permanente
2022
University of California, San Diego
2015-2020
// John Paul Shen 1,2 , Rohith Srivas 1,8 Andrew Gross 3 Jianfeng Li 4,5,9 Eric J. Jaehnig 1,6 Su Ming Sun 7 Ana Bojorquez-Gomez 1 Katherine Licon Vignesh Sivaganesh Jia L. Xu Kristin Klepper Huwate Yeerna Daniel Pekin Chu Ping Qiu Haico van Attikum Robert W. Sobol and Trey Ideker 1,2,3 Department of Medicine, University California San Diego, La Jolla, CA, USA 2 Moores Cancer Center, Bioinformatics Systems Biology Program, 4 Pharmacology Chemical Biology, Pittsburgh School Pittsburgh, PA, 5...
Abstract Background Facial baroparesis is a palsy of the seventh cranial nerve resulting from increased pressure compressing along its course through middle ear cavity. It rare condition, most commonly reported in barotraumatic environments, particular scuba diving and high-altitude air travel. We report here an unusual case highly frequent baroparesis, workup, successful treatment. Case presentation A 57-year-old Caucasian male commercial airline traveler presented with 4-year history...
Introduction With the number of COVID cases in children increasing, variation presentation seen pediatric patients compared with adults has become more apparent. The typical adult COVID-19 infection, generally associated acute respiratory symptoms, seems to differ from that children, many whom are initially asymptomatic. Case Presentation In this case, a previously healthy female adolescent presented insidious onset nausea and weight loss, but broad gastrointestinal workup was unrevealing....
Abstract An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets. Here, we develop resource of synthetic-lethal genes mutated cancer, including many suppressor (TSG), chemical inhibitors FDA-approved drugs, using an integrative multi-species approach. Whereas, targeting oncogenes with either or antibodies has proven be highly effective therapy, it not currently feasible restore...
Abstract PURPOSE: Like many solid tumors, high grade serous ovarian carcinoma (HGSOC) is a heterogeneous entity with widely variable clinical course even among patients of the same stage and histological subtype. Although most will achieve remission platinum-based chemotherapy, approximately 20% display primary platinum resistance. If it were possible to resistance from molecular profile tumor, resistant tumor could be identified for alternative therapy, however, currently no such biomarker...
5561 Background: High-grade serous ovarian carcinoma (HGS-OvCa) is a heterogeneous entity with widely variable clinical course even among patients of the same stage and histological subtype. Although most will achieve remission platinum-based chemotherapy, ~20% display primary platinum resistance. Currently no biomarker exists to identify these resistant patients. Methods: We have recently developed method called Network-based Stratification (NBS), which combines genome-scale somatic...
Abstract Genetic interactions, in particular negative or "synthetic-lethal" interactions for which simultaneous disruption of two genes causes cell killing, have implications therapeutic development as has been demonstrated by the clinical success PARP inhibitors specifically tumors with loss-of-function mutations BRCA1/2. However, further applications synthetic-lethal cancer therapy limited poor understanding important genetic a cell, and how these vary from one type to another patient...