Lena Gorgannezhad

ORCID: 0000-0001-5086-1288
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About
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Research Areas
  • Advanced biosensing and bioanalysis techniques
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Microfluidic and Capillary Electrophoresis Applications
  • Biosensors and Analytical Detection
  • Cancer Genomics and Diagnostics
  • Pickering emulsions and particle stabilization
  • Microfluidic and Bio-sensing Technologies
  • Electrochemical sensors and biosensors
  • Enzyme Catalysis and Immobilization
  • RNA Interference and Gene Delivery
  • Protein Interaction Studies and Fluorescence Analysis
  • Mesoporous Materials and Catalysis
  • Renal and related cancers
  • Polymer Surface Interaction Studies
  • Surface Modification and Superhydrophobicity
  • MicroRNA in disease regulation
  • Synthesis and Characterization of Heterocyclic Compounds
  • Gene expression and cancer classification
  • Enzyme-mediated dye degradation
  • Metal complexes synthesis and properties
  • Graphene and Nanomaterials Applications
  • Proteins in Food Systems
  • Free Radicals and Antioxidants
  • Single-cell and spatial transcriptomics
  • Electrohydrodynamics and Fluid Dynamics

Griffith University
2017-2024

Payame Noor University
2015

The polymerase chain reaction (PCR) is a popular and well-established DNA amplification technique. Technological engineering advancements in the field of microfluidics have fuelled progress technology last three decades. Advances microfluidics-based PCR significantly reduced sample volume thermal cycling time. Further advances led to novel accurate techniques such as digital PCR. However, contamination samples, lack reusability microfluidic platforms, complexity instrumentation operation...

10.1039/c9lc00676a article EN Lab on a Chip 2019-01-01

Over the last three decades, protocols and procedures of DNA amplification technique, polymerase chain reaction (PCR), have been optimized well developed. However, there no significant innovations in processes for sample dispersion PCR that reduced amount single-use or unrecyclable plastic waste produced. To address issue waste, this paper reports synthesis successful use a core-shell bead microreactor using photopolymerization composite liquid marble as process. This platform uses simple...

10.3390/mi11030242 article EN cc-by Micromachines 2020-02-26

Abstract We report the electrocatalytic activity of a new class superparamagnetic nanoparticles, graphene‐oxide‐loaded iron oxide (GO/IO hybrid material), towards reduction ruthenium hexaammine(III) chloride (Ru(NH 3 ) 6 ] 3+ , RuHex). Leveraging GO/IO material and signal enhancement capacity [Ru(NH /[Fe(CN) 3− in an cycle, ultrasensitive specific electrochemical sensor was developed for detection cancer‐related microRNA (miRNA). Using direct affinity interaction between RNA graphene oxide,...

10.1002/celc.201800339 article EN ChemElectroChem 2018-06-12

Abstract Circulating tumor nucleic acids (ctNAs) are promising biomarkers for minimally invasive cancer assessment. The FGFR2 : FAM76A fusion gene is one of the highly ovarian detectable in ctNAs. Herein, we introduce a new amplification‐free electrochemical assay detection ctNAs extracted from patients. relies on electrocatalytic activity class superparamagnetic graphene‐loaded iron oxide nanoparticles (GO‐NPFe 2 O 3 ). After isolation and purification, target RNA was directly adsorbed onto...

10.1002/elan.201800282 article EN Electroanalysis 2018-07-04

The polymerase chain reaction (PCR) is a robust technique used to make multiple copies of segment DNA. However, the available PCR platforms require elaborate and time-consuming operations or costly instruments, hindering their application. Herein, we introduce sandwiched glass–polydimethylsiloxane (PDMS)–glass microchip containing an array reactors for real-time PCR-based detection waterborne bacteria. solution was loaded into in single step utilising capillary filling, eliminating need...

10.3390/mi10120883 article EN cc-by Micromachines 2019-12-16

A highly dispersible and magnetically recoverable Cu-PEI@Fe$_{3}$O$_{4}$ MNPs catalyst was prepared successfully applied in one-pot three-component coupling of terminal alkynes, sodium azide, alkyl bromides/chlorides water to give 1,4-disubstituted 1,2,3-triazoles with good excellent yields. The fully characterized FT-IR, TGA, TEM, SEM, VSM, EDX, cyclic voltammetry, ICP-AES spectroscopic techniques. Furthermore, the easily recycled by an external magnet reused six times reaction without...

10.3906/kim-1607-40 article EN TURKISH JOURNAL OF CHEMISTRY 2017-01-01

Multiplex polymerase chain reaction (PCR) is an effective tool for simultaneous detection of target genes. Nevertheless, their use has been restricted due to the intrinsic interference between primer pairs. Performing several single PCRs in array format instead a multiplex PCR simple way overcome this obstacle. However, there are still major technical challenges designing new generation microreactors with small sample volume, rapid thermal cycling, and no evaporation during amplification. We...

10.3390/mi11080761 article EN cc-by Micromachines 2020-08-07
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