A5064754827- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Noise Effects and Management
- Vestibular and auditory disorders
- Neuroscience of respiration and sleep
- Coenzyme Q10 studies and effects
- Marine animal studies overview
- Calcium signaling and nucleotide metabolism
- Genomics, phytochemicals, and oxidative stress
- Connexins and lens biology
- Immune Response and Inflammation
- Genetically Modified Organisms Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Bat Biology and Ecology Studies
- Ion Channels and Receptors
- Olfactory and Sensory Function Studies
- Advanced battery technologies research
- Bioeconomy and Sustainability Development
- Synthesis of Organic Compounds
- Bioactive Compounds and Antitumor Agents
- Curcumin's Biomedical Applications
- Insect Resistance and Genetics
Università Cattolica del Sacro Cuore
2010-2018
This study addresses the relationship between cochlear oxidative damage and auditory cortical injury in a rat model of repeated noise exposure. To test effect increased antioxidant defenses, water-soluble coenzyme Q 10 analog (Q ter ) was used. We analyzed function, stress, morphological alterations cortices structures, levels coenzymes 9 (CoQ CoQ , respectively) as indicators endogenous capability. report three main results. First, hearing loss hair cells spiral ganglion determined by...
In oncology, an emerging paradigm emphasises molecularly targeted approaches for cancer prevention and therapy the use of adjuvant chemotherapeutics to overcome cisplatin limitations. Owing their safe use, some polyphenols, such as curcumin, modulate important pathways or molecular targets in cancers. This paper focuses on curcumin molecule by analysing its potential implications targets, signal transducer activator transcription 3 (STAT3) NF-E2 p45-related factor 2 (Nrf-2), tumour...
To investigate whether curcumin may have in vivo protective effects against cisplatin ototoxicity by its direct scavenger activity and/or curcumin-mediated upregulation of HO-1.Cisplatin-induced is a major dose-limiting side effect anticancer chemotherapy. A approach to decrease without compromising therapeutic efficacy remains critical goal for therapy. Recent evidences indicate that exhibits antioxidant, anti-inflammatory, and chemosensitizer activities.In male adult Wistar rats, dose 200...
Trans-tympanic Rosmarinic Acid (RA), as compared with the systemic administration, protects against noise-induced auditory hair cell and hearing losses in rats vivo.ROS production, lipoperoxidative damage, an imbalance of antioxidant defences play a significant role loss. Several molecules properties have been tested to restore redox homeostasis; however, drug delivery system represents challenge for their effectiveness. In our model, acute intense noise exposure induces loss, death,...
Abstract p66 shc , a member of the ShcA protein family, is essential for cellular response to oxidative stress, and elicits formation mitochondrial Reactive Oxygen Species (ROS), thus promoting vasomotor dysfunction inflammation. Accordingly, mice lacking isoform display increased resistance tissue damage cardiovascular disorders. Oxidative stress also contributes noise-induced hearing loss (NIHL); we found that expression serine phosphorylation were induced following noise exposure in rat...
Conclusion: The effectiveness of a coenzyme Q10 formulation, Q-ter, given via transtympanic injection is interesting for the future application this minimally invasive procedure in treatment reactive oxygen species (ROS)-induced hearing loss. Objective: We focused on antioxidant therapy noise-induced loss (NIHL). Our study was designed to evaluate Q-ter different schedules drug administration establish best modality treatment. Methods: Rats were exposed acoustic trauma (10 kHz at 120 dB 60...
Noise exposure causes damage of multiple cochlear cell types producing permanent hearing loss with important social consequences. In mammals, no regeneration either damaged hair cells or auditory neurons has been observed and successful treatment is available to achieve a functional recovery. Several evidences indicate adipose-derived stem (ASCs) as promising tools in diversified regenerative medicine applications, due the high degree plasticity trophic features. This study was aimed at...
Conclusion: Our results are in agreement with the general idea that natural antioxidants achieve their best cytoprotective capacity if given before and soon after stressor. Objective: We focused on ferulic acid (FA, 4-hydroxy 3-methoxycinnamic acid), a phenolic compound is known to exhibit antioxidant properties. study was designed evaluate effectiveness of FA for different schedules treatment establish ‘therapeutic window’ protection. Methods: Guinea pigs were exposed acoustic trauma (6 kHz...
Objective: Oxidative stress plays a significant role in noise induced hearing loss (NIHL) as it largely participates the mechanisms that underlie cell death after exposure and leads to sensorineural loss. Many antioxidant drugs have been tested prevent NIHL. Study design: We compared protective effects of five molecules having properties (vitamin E, ferulic acid, active CoQ10, its synthetic analogue – idebenone, soluble formulation CoQ ter ) our laboratory. This study has conducted model...