A5074533920- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Vestibular and auditory disorders
- Stress Responses and Cortisol
- Sleep and related disorders
- Cholinesterase and Neurodegenerative Diseases
- Neuroendocrine regulation and behavior
- Nicotinic Acetylcholine Receptors Study
- Neuroinflammation and Neurodegeneration Mechanisms
- Sleep and Wakefulness Research
- Nerve injury and regeneration
- Maternal Mental Health During Pregnancy and Postpartum
- Infant Development and Preterm Care
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- COVID-19 and Mental Health
- Neuropeptides and Animal Physiology
- Circadian rhythm and melatonin
- Autoimmune Neurological Disorders and Treatments
- Action Observation and Synchronization
- Olfactory and Sensory Function Studies
- Fatty Acid Research and Health
- Genetic Neurodegenerative Diseases
Marconi University
2015-2024
Fondazione Santa Lucia
2013-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2011-2022
Univar (United Kingdom)
2017
Sapienza University of Rome
2008-2014
Alterations of the dopaminergic (DAergic) system are frequently reported in Alzheimer's disease (AD) patients and commonly linked to cognitive non-cognitive symptoms. However, cause DAergic dysfunction AD remains be elucidated. We investigated alterations midbrain Tg2576 mouse model AD, overexpressing a mutated human amyloid precursor protein (APPswe). Here, we found an age-dependent neuron loss ventral tegmental area (VTA) at pre-plaque stages, although substantia nigra pars compacta (SNpc)...
This study addresses the relationship between cochlear oxidative damage and auditory cortical injury in a rat model of repeated noise exposure. To test effect increased antioxidant defenses, water-soluble coenzyme Q 10 analog (Q ter ) was used. We analyzed function, stress, morphological alterations cortices structures, levels coenzymes 9 (CoQ CoQ , respectively) as indicators endogenous capability. report three main results. First, hearing loss hair cells spiral ganglion determined by...
Systemic inflammation might cause neuronal damage and sustain neurodegenerative diseases behavior impairment, with the participation of pro-inflammatory cytokines, like tumor necrosis factor (TNF)-α interleukin (IL)-18. However, potential contribution these cytokines to behavioral impairment in long-term period has not been fully investigated.Wistar rats were treated a single intraperitoneal injection LPS (5 mg/kg) or vehicle. After 7 days 10 months, animal was evaluated by testing specific...
As major components of neuronal membranes, omega-3 polyunsaturated acids (n-3 PUFA) exhibit a wide range regulatory functions, modulating from synaptic plasticity to neuroinflammation, oxidative stress neuroprotection. Recent human and animal studies indicated the n-3 PUFA neuroprotective properties in aging, with clear negative correlation between levels hippocampal deficits. The present multidimensional study was aimed at associating cognition, neurogenesis, volume, neurodegeneration...
Objectives: One of the largest clusters Covid-19 infections was observed in Italy. The population forced to home confinement, exposing individuals increased risk for insomnia, which is, turn, associated with depression and anxiety. Through a cross-sectional online survey targeting all Italian adult (≥18 yrs), insomnia prevalence its interactions relevant factors were investigated. Methods: distributed from 1st April 4th May 2020. We collected information on severity, depression, anxiety,...
Intraparenchymal injections of the immunotoxin 192-IgG-saporin into medial septum and nucleus basalis magnocellularis causes a selective depletion basal forebrain cholinergic neurons. Thus, it represents valid model to mimic key component cognitive deficits associated with aging dementia. Here we administered donepezil, potent acetylcholinesterase inhibitor developed for treating Alzheimer's disease, 15 days before injection, thus examined donepezil effects on neurodegeneration...
Stiff Person Syndrome (SPS) is a rare autoimmune movement disorder characterized by the presence of autoantibodies specific to smaller isoform glutamate decarboxylase (GAD65). A pathological role these antibodies has been suggested their capacity inhibit GAD65 enzyme activity and observation that rats receiving cerebellar injections GAD65Ab showed motor hyperexcitability. To assess effect epitope-specific on cognitive functions, we conducted behavioral experiments in received with two...
To experimentally verify the reserve hypothesis, influence of rearing conditions on cognitive performances and dendritic spines following basal forebrain lesions was analyzed. Adult rats reared in enriched or standard were deple
Environmental enrichment (EE) defined as "a combination of complex inanimate and social stimulation" influences brain function anatomy by enhancing sensory, cognitive, motor, stimulation. The beneficial effects EE in the presence damage have been partially attributed to upregulation neurotrophins, proteins involved neuronal survival activity-dependent plasticity.The authors tested hypothesis that may advantageous on recovery motor after cerebellar damage, associated with changes local...
Environmental enrichment is usually applied immediately after weaning or in adulthood, with strong effects on CNS anatomy and behavior. To examine the hypothesis that a pre-reproductive environmental of females could affect motor development their offspring, female rats were reared an enriched environment from to sexual maturity, while other used as controls under standard conditions. Following mating standard-reared males, all housed individually. evaluate eventual transgenerational...
Environmental enrichment (EE) is a widely used paradigm for investigating the influence of complex stimulations on brain and behavior. Here we examined whether pre-reproductive exposure to EE female rats may their maternal care offspring cognitive performances. To this aim, from weaning breeding age enriched females (EF) were reared in environments. Females standard conditions as controls. At 2.5 months all mated with offspring. Maternal behaviors nesting activity assessed lactating dams....
SUMMARY Insomnia and circadian dysregulation during adolescence represent important risk factors for emotional psychological problems. Recent studies have shown that the coronavirus disease 2019 (COVID‐19) pandemic has been linked to a high prevalence of behavioural sleep problems in general population. This study aimed provide two pictures different time points regarding adolescents their association with health variables. Two independent large samples Italian aged 13–17 years were...
Sleep is vital for maintaining individuals' physical and mental health particularly challenged during pregnancy. More than 70% of women the gestational period report insomnia symptoms. dysfunction in peripartum increases risk a cascade negative outcomes late pregnancy, birth, postpartum. While psychological interventions are considered first line treatment sleep difficulties, they still scarcely offered pregnancy there lack longitudinal research combining physiological indices. The present...
Since acute and chronic administration of the acetylcholinesterase inhibitors, namely donepezil, improves cognitive functions in patients afflicted by mild to moderate dementia reverses memory deficits experimental models learning memor
Several studies have documented an involvement of Neuropeptide Y (NPY) in stress-related disorders. Stress-related disorders are also characterized by changes brain-derived neurotrophic factor (BDNF) and nerve growth (NGF), neurotrophins implicated the survival function neurons. Thus aim this study was to investigate whether NPY intraperitoneal treatment has antidepressant-like effects rats subjected a classical stress paradigm, Forced Swim Test (FST), association with local brain...
In recent years, mechanistic, epidemiologic, and interventional studies have indicated beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) against brain aging age-related cognitive decline, with the most consistent Alzheimer's disease (AD) confined especially in early or prodromal stages pathology. present study, we investigated action n-3 PUFA supplementation on behavioral performances hippocampal neurogenesis, volume, astrogliosis aged mice subjected to a selective...