A5007561190- Mechanical Circulatory Support Devices
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Glioma Diagnosis and Treatment
- Viral Infections and Immunology Research
- Central Venous Catheters and Hemodialysis
- MRI in cancer diagnosis
- Heart Failure Treatment and Management
- Vascular anomalies and interventions
- Radiomics and Machine Learning in Medical Imaging
- Congenital Heart Disease Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Lung Cancer Diagnosis and Treatment
- Erythropoietin and Anemia Treatment
- Cardiac Ischemia and Reperfusion
- Poisoning and overdose treatments
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Membrane-based Ion Separation Techniques
- Cardiomyopathy and Myosin Studies
Hospital of the University of Pennsylvania
2024-2025
University of Pennsylvania
2020-2024
NYU Langone Health
2023
Reading Hospital
2019-2020
Northwestern University
2014
Abstract Background Glucocorticoid treatment remains the cornerstone of therapy for immune checkpoint inhibitor (ICI) myocarditis, but data supporting use additional immunotherapy steroid refractory cases limited. We investigate safety and efficacy infliximab in patients with ICI myocarditis who are to corticosteroids. Additionally, we highlight importance a multi-disciplinary approach care these complex patients. Methods retrospectively identified consecutive developed at our institution...
ABSTRACT Phrenic nerve injury, though rare, can be a serious complication of catheter ablation leading to significant morbidity. The close proximity the phrenic site origin arrhythmias may also impact success ablation. When is near optimal ablation, several techniques have been proposed create separation between and epicardium, including introduction fluid, gas, balloons. In this article, we present step‐by‐step approach displacement facilitate review anatomy, localization techniques,...
We report on the clinical course and management of patients supported with durable implantable LVADs who developed outflow graft obstructions at a large academic center. performed retrospective review receiving LVAD support from 2012 through 2020. Patients an obstruction diagnosed by computed tomography angiography (CTA) or angiogram were identified, patient characteristics outcomes reported. Of 324 our institution, 11 (3.4%) obstructions. The most common presentation was low flow alarms,...
Continuous-flow left ventricular assist devices (CF-LVAD) have been shown to enhance reverse remodeling and myocardial recovery in certain patients allowing for device removal. We sought analyze the characteristics describe outcomes of who underwent CF-LVAD explantation at a large academic center. retrospectively identified all explants due from 2006 2019. Patient baseline data on pre- postexplant evaluation were collected analyzed. Of 421 implantation, 13 (3.1%). Twelve HeartMate II one...
We aimed to identify a simple metric accounting for peri-procedural hemoglobin changes, independent of blood product transfusion strategies, and assess its correlation with outcomes in patients undergoing left ventricular assist device (LVAD) implantation included consecutive LVAD at single center between 10/1/2008 6/1/2014. The anemia stress index (ASI), defined as the sum number packed red cells transfused changes after implantation, was calculated each patient 24 h, discharge, 3 months...
Abstract Objectives To investigate tailored approaches, techniques, and outcomes of catheter ablation in patients with persistent left superior vena cava (PLSVC) undergoing atrial fibrillation (AF) ablation. Background PLSVC presents unique challenges for AF due to its potential as an arrhythmogenic source the complex anatomical variations it introduces. Methods The retrospective cohort included 16 that underwent 21 procedures between August 1, 2008, February 14, 2024, at Hospital University...
Introduction/Background: Persistent Left Superior Vena Cava (PLSVC) presents unique challenges for atrial fibrillation (AF) ablation due to its arrhythmogenic potential and complex anatomical variations. Understanding tailored approaches outcomes in patients with PLSVC AF is essential improving procedural success safety. Research Questions/Hypothesis: This study aims investigate the efficacy of strategies AF. Goals/Aims: To evaluate safety, acute success, recurrence rate post-ablation PLSVC,...
Background: The majority of non-pulmonary vein (PV) triggers atrial fibrillation (AF) require provocative maneuvers for induction during catheter ablation. Identifying a subset patients with higher likelihood having non-PV can guide more efficient use these maneuvers. Objective: This study aims to identify pre-procedural risk factors the presence at first-time AF Methods: We included who underwent ablation between 2019 and 2022 Hospital University Pennsylvania. Non-PV trigger provocation...
Patients undergoing first-time atrial fibrillation (AF) ablation can benefit from targeting non-pulmonary vein (PV) triggers. Preprocedural identification of high-risk individuals guide planning strategy. This study aimed to create a preprocedural screening tool identify patients at risk non-PV triggers during AF ablation.
Introduction: The contribution of chronotropic incompetence to reduced exercise tolerance after a heart transplant is well known, but its role as prognostic marker post-transplant mortality unclear. aim this study examine the relationship between rate response (HRR) and survival. Methods: We performed retrospective analysis all adult recipients at University Pennsylvania years 2000 2011 who underwent cardiopulmonary test (CPET) within year transplant. Follow-up time survival status were...
While it is common practice to use intravenous (IV) iron in patients with left ventricular assist devices (LVADs) and deficiency, there insufficient evidence regarding outcomes this patient population. We evaluated the safety effectiveness of IV therapy supported by LVADs deficiency.We performed a retrospective analysis deficient on continuous LVAD support at large academic center between 2008 2019. Patients were divided into two cohorts based sucrose treatment. The primary endpoint was...
PURPOSE: Epileptic seizure is a common presentation for patients with malignant glioma. Although the biological mechanisms which produce tumor-associated seizures are unclear, more prevalent in grade II gliomas. We hypothesized that an invasive growth kinetic would be associated incidence at presentation, and this association may explain why non-grade IV gliomas likely to present seizures. METHODS: A total of 354 contrast enhancing WHO (N = 13), III 28), 313) were studied. incorporated...
There are limited data on the characteristics and clinical course of fungal infections in patients durable left ventricular assist device (LVAD) support. We sought to further characterize epidemiology outcomes LVAD with fungemia. performed a retrospective review receiving support from January 2012 through June 2020 at large academic institution. Among 336 support, five (1.4%) were diagnosed fungemia during study period. Three had diabetes mean hemoglobin A1c 7.1% (R 6.6, 7.4). Fever...
BACKGROUND: The Days Gained (DG) response metric, which incorporates knowledge of the tumor growth rate, has been shown to correlate with progression-free (PFS) and overall survival (OS) following concurrent chemoradiotherapy for newly diagnosed glioblastoma (Neal et al., 2013 PLOS One; Neal Cancer Research). We describe first use this metric analyze radiographic recurrent malignant gliomas large-volume re-irradiation using proton beam therapy (PBT). METHODS: equation described in Neal, was...