A5033355455- Metal complexes synthesis and properties
- Computational Drug Discovery Methods
- Mycotoxins in Agriculture and Food
- Titanium Alloys Microstructure and Properties
- Bone Tissue Engineering Materials
- SARS-CoV-2 and COVID-19 Research
- Tissue Engineering and Regenerative Medicine
- Heavy Metal Exposure and Toxicity
- Plant Disease Resistance and Genetics
- Orthopaedic implants and arthroplasty
- COVID-19 Clinical Research Studies
- Pesticide Exposure and Toxicity
- Air Quality and Health Impacts
- Magnesium Alloys: Properties and Applications
- Drug-Induced Hepatotoxicity and Protection
- Endodontics and Root Canal Treatments
- Ferrocene Chemistry and Applications
- Electrospun Nanofibers in Biomedical Applications
- Synthesis and Biological Evaluation
- Animal testing and alternatives
- Occupational exposure and asthma
- Silk-based biomaterials and applications
- Protein Interaction Studies and Fluorescence Analysis
- Electrochemical Analysis and Applications
- Radiation Effects and Dosimetry
TÜBİTAK Marmara Research Center
2013-2024
Scientific and Technological Research Council of Turkey
2013-2024
Biotechnology Institute
2013-2017
Fatih University
2012
Joint Research Centre
2008-2010
European Commission
2009
University of Nebraska–Lincoln
2000-2006
Changes in weather conditions and lifestyle lead to an annual increase the amount of lung cancer, therefore it is one three most common types making important find appropriate treatment method. This research aims introduce a new smart nano-drug delivery system with antibacterial anticancer capabilities that could be applied for cancer. It composed niosomal carrier containing curcumin as drug coated chitosan polymeric shell, alongside Rose Bengal (RB) photosensitizer feature. The...
Small molecule inhibitors have previously been investigated in different studies as possible therapeutics the treatment of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In current drug repurposing study, we identified leukotriene (D4) receptor antagonist montelukast a novel agent that simultaneously targets two important SARS-CoV-2. We initially demonstrated dual inhibition profile through multiscale molecular modeling studies. Next, characterized its effect on both by vitro...
Epidemiological studies show that cadmium (Cd) exposure causes pulmonary damage, such as emphysema, pneumonitis, and lung cancer. However, the mechanisms leading to toxicity are not yet fully elucidated. The aim of this study was further investigate chloride (CdCl(2)) induced using Calu-3 cells an in vitro model human bronchial epithelial cells. CdCl(2) effects following either apical or basolateral were evaluated by Neutral Red Uptake (NRU), Trans-Epithelial Electrical Resistance (TEER),...
Metal-based compounds represent promising anticancer therapeutic agents. In this study, the mechanism of action a novel metal-based drug, palladium(II) (Pd) complex ([PdCl(terpy)](sac)·2H2O, terpy=2,2′:6′,2′′-terpyridine and sac=saccharinate), was elucidated. The tested compound induced cytotoxicity in nine different human cancer cell lines that originated from various organs, suggesting broad spectrum activity. IC50 values were significantly higher for noncancerous cells when compared with...
The objective of this study was to determine loss toxicity zearalenone in extruded cereal-based products by the MTT (tetrazolium salt) cell proliferation assay using a sensitive MCF-7 human breast cancer line and compare results chemical (high-performance liquid chromatography, HPLC) biochemical (enzyme-linked immunosorbent assay, ELISA) methods analysis. A split−split plot design used for extrusion process experiments at temperatures 150, 175, 200 °C screw speeds 70 140 rpm. initial...
This study investigated the microstructures, mechanical performances, corrosion resistances, and in vitro studies of porous Ti-xNb-10Zr (x: 10 20; at. %) alloys. The alloys were fabricated by powder metallurgy with two categories porosities, i.e., 21–25% 50–56%, respectively. space holder technique was employed to generate high porosities. Microstructural analysis performed using various methods including scanning electron microscopy, energy dispersive spectroscopy, backscatter diffraction,...
Abstract Introduction Numerous efforts in natural product drug development are reported for the treatment of Coronavirus. Based on literature, among these plants Artemisia annua L . shows some promise SARS‐CoV‐2. Objective The main objective our study was to determine artemisinin content by liquid chromatography electrospray ionisation tandem mass spectrometry (LC‐ESI‐MS/MS), investigate vitro biological activity from A. grown Turkey with various extracted methods, elaborate silico against...
Posters, either as promotions by various ELT publishing houses or prepared teachers and students, are widely used on the walls of many foreign language classrooms. Many them consist colourful pictures along with L2 vocabulary, grammar, texts in order to contribute learning process. However, envisage posters only decorative class motifs rather than educational tools themselves. The aim this study, conducted a private Turkish primary school, is show that students can actually enhance their...
The main aim of this study is to assess the safety and antitumor efficacy a palladium(II) (Pd)-saccharinate complex with terpyridine. To characterize Pd(II) in vitro, its cytotoxicity was evaluated using water-soluble tetrazolium salt cell viability assay mechanism death assessed by DNA fragmentation/condensation live imaging analyses. in-vivo were examined analyzing reduction tumor size, changes body organ weight, histopathological analysis liver, kidney, sections, biochemical serum C57BL/6...
In October 2006, the European Centre for theValidation of Alternative Methods (ECVAM) spon-sored and hosted a three-day workshop to consideropportunities challenges in development ofalternative methods identification char-acterisation chemical respiratory allergens. Theproceedings, conclusions recommendations ofthat were subsequently made available asECVAM Workshop Report 60 (1).In April 2008, second meeting was convenedby ECVAM consider what progress has beenmade light derivedfrom 2006...
Nowadays, cancer represents one of the major causes death in humans worldwide, which renders quest for new and improved antineoplastic agents to become an urgent issue field biomedicine human health. The present research focuses on synthesis 2,3,2',3'-tetra(pyridin-2-yl)-6,6'-biquinoxaline) (2,3,2',3'-tetra(thiophen-2-yl)-6,6'-biquinoxaline) containing copper(II) platinum(II) compounds as prodrug candidates. binding interaction these with calf thymus DNA (CT-DNA) serum albumin were assessed...
Titanium-Niobium (TiNb) alloys are commonly employed in a number of implantable devices, yet concerns exist regarding their use implantology owing to the biomechanical mismatch between implant and host tissue. Therefore, balance mechanical performance load-bearing with bone, TiNb differing porosities were fabricated by powder metallurgy combined spacer material. Microstructures phase constituents characterized energy dispersive spectroscopy (EDS), scanning electron microscopy (SEM), X-ray...
The objective of this study was to determine the loss toxicity deoxynivalenol in extruded cereal-based products by tetrazolium salt (MTT) bioassay using a sensitive Chinese hamster ovary (CHO-K1) cell line and compare results chemical (high-performance liquid chromatography, HPLC) biochemical (enzyme-linked immunosorbant assay, ELISA) methods analysis. A split−split plot design used for extrusion process experiments at temperatures 150, 175, 200 °C screw speeds 70 140 rpm. initial mean...
Cardiac tissue engineering focusing on biomaterial scaffolds incorporating cells from different sources has been explored to regenerate or repair damaged area as a lifesaving approach.The aim of this study was evaluate the cardiomyocyte differentiation potential human adipose mesenchymal stem (hAD-MSCs) an alternative cell source silk fibroin (SF) for cardiac engineering. The change in surface morphology SF depending concentration (1-6%, w/v) and increase their porosity upon application...