A5030487245- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Hematopoietic Stem Cell Transplantation
- Reproductive System and Pregnancy
- Long-Term Effects of COVID-19
- Immunotherapy and Immune Responses
- Neutropenia and Cancer Infections
Lancashire Teaching Hospitals NHS Foundation Trust
2023-2024
University of Birmingham
2022
Our study was conducted to optimise a peptide stimulation and an intracellular cytokine staining protocol, alongside Bio-Plex supernatant analysis, for use in patients who had previously contracted SARS-CoV-2 or received vaccination against this virus clinical laboratory setting. Peripheral Blood Mononuclear Cell extraction cryopreservation allowed cells be stored long term enhanced logistical processing of samples. Viability functionality were analysed by flow cytometric methodology using...
Recombinant granulocyte colony-stimulating factor (G-CSF) is frequently administered to patients with cancer enhance recovery post-chemotherapy. Clinical trials have also used G-CSF modulate myeloid cell function in pregnancy and inflammatory diseases. Although the contribution of expanding normal granulocytes well known, effect this cytokine on phenotype immunosuppressive granulocytic cells remains unclear. Here, we investigate impact physiological iatrogenic an as yet undescribed ensuing...
The difference in the immune response to severe acute respiratory syndrome coro-navirus 2 (SARS-CoV-2) patients with mild versus disease remains poorly understood. Recent scientific advances have recognised vital role of both B cells and T cells; however, many questions remain unanswered, particularly for cell responses. are essential helping generation SARS-CoV-2 antibody responses but also been their own right as a major factor influencing COVID-19 outcomes. examination receptor (TCR)...