A5064196485- Bioactive Compounds in Plants
- Cancer Treatment and Pharmacology
- Neurological Disease Mechanisms and Treatments
- Blood Pressure and Hypertension Studies
- Legume Nitrogen Fixing Symbiosis
- Phytochemicals and Antioxidant Activities
- Breast Cancer Treatment Studies
- Flavonoids in Medical Research
- Cancer survivorship and care
- Hormonal Regulation and Hypertension
- Chronic Lymphocytic Leukemia Research
- Global Public Health Policies and Epidemiology
- Advanced Breast Cancer Therapies
- Mycorrhizal Fungi and Plant Interactions
- Pharmacological Receptor Mechanisms and Effects
- HER2/EGFR in Cancer Research
- Plant Pathogens and Resistance
- Tryptophan and brain disorders
- Lung Cancer Treatments and Mutations
- Bioactive natural compounds
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chemotherapy-related skin toxicity
- Lymphoma Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
Ilia State University
2014-2023
National Institute on Drug Abuse
2020
Bordeaux Population Health
2019
Institut de Biochimie et Génétique Cellulaires
2019
Background Recent climatic history has strongly impacted plant populations, but little is known about its effect on microbes. Alders, which host few and specific symbionts, have high genetic diversity in glacial refugia. Here, we tested the prediction that communities of root symbionts survived refugia with their populations. We expected to detect endemic a higher species richness as compared recolonized areas. Methods sampled ectomycorrhizal (EM) tips nitrogen-fixing actinomycete Frankia...
e23172 Background: Ovarian function suppression (OFS) is recommended for premenopausal patients with hormone (HR) positive early breast cancer at higher risk of recurrence. This achieved the use luteinizing hormone–releasing agonist (LHRH) or oophorectomy. Sexual health an important aspect women cancer, although unfortunately this issue often not addressed. The aim study was to explore sexual issues in HR-positive LHRH vs. Oophorectomy. Methods: A prospective observational conducted during...
ObjectiveEvaluation of the effect citrus flavonoid – nobiletin on bioenergetics synaptic and non-synaptic mitochondria in hippocampus hypothyroid rats.MethodsMale Wistar rats were divided into (methimazole-treated), supplemented hypothyroid, thyroxine-treated euthyroid (control) groups. Synaptic (cell) isolated from hippocampus. Oligomycin-sensitive, oligomycin-insensitive, α-ketoglutarate dehydrogenase-dependent synthesis adenosine triphosphate (ATP), succinate dehydrogenase, hexokinase...
Nobiletin is an 0-methylated flavonoid found in citrus peels that have anticancer, antiviral, neuroprotective; anti-inflammatory activities and depending on the cell types exhibits both pro- or anti-apoptotic properties We nobiletin decreases oxygen consumption by bovine brain isolated mitochondria presence of glutamate malate increases succinate. In paralleli NADH: oxidation, a-ketoghitarate dehydrogenase through matrix substrate-level phosphorylation elevates...
The hypothesis stated here that, the long-term prevention by natural flavonoid phenolic compound, for example apigenin (Apg), improves baroreflex sensitivity and vascular resistance occurs beneficial action attenuation renal hypertension (RH). One-kidney, 1-clip rats (1K1C) were treated with Apg 2 weeks after 1 week of surgical intervention. At end study in control RH group blood pressure (BP) increased on average 43.5%, decreased heart period (HP) 9.8%, cardiochronotropic (vagal) component...
e13529 Background: The availability of comprehensive cancer care in different regions is the main problem developing countries. In fact, centers are centralized and patients fail to receive proper medical regions. situation critical for living zones conflict. Georgia we have only two cities Tbilisi Kutaisi. aim study was investigate rate gastric diagnoses Georgia, that could be a model Methods: spread investigated retrospectively by analyzing cases reported based on 5 years national registry...
This study aimed to analyze pharmacological actions of phenolic compound luteolin on the renal and cardiac hypertrophy, blood pressure (BP), baroreflex sensitivity (BRS), levels epoxyeicosatrienoic acids (EETs), prostaglandin E-2 (PGE-2) endothelin-1 (E1) in plasma 2 kidney - 1 clip (2K-1C) model renovascular hypertension (RVH). All animals, were randomized into groups: control (normal) I sham-operated, II- RVH male Wistar rats, which after 4 weeks surgical intervention secondly II group,...