A5093096593- Advanced biosensing and bioanalysis techniques
- Iron oxide chemistry and applications
- Block Copolymer Self-Assembly
- Bacteriophages and microbial interactions
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticles: synthesis and applications
- Biosensors and Analytical Detection
- Modular Robots and Swarm Intelligence
- Polymer Surface Interaction Studies
- DNA and Biological Computing
- RNA Interference and Gene Delivery
- Coagulation and Flocculation Studies
Columbia University
2023-2024
Sophisticated statistical mechanics approaches and human intuition have demonstrated the possibility of self-assembling complex lattices or finite-size constructs. However, attempts so far mostly only been successful in silico often fail experiment because unpredicted traps associated with kinetic slowing down (gelation, glass transition) competing ordered structures. Theoretical predictions also face difficulty encoding desired interparticle interaction potential experimentally available...
Self-assembly of isotropically interacting particles into desired crystal structures could allow for creating designed functional materials via simple synthetic means. However, the ability to use isotropic assemble different types remains challenging, especially generating low-coordinated structures. Here, we demonstrate that pairwise interparticle interactions can be rationally tuned through design DNA shells in a range allows transition from common, high-coordinated FCC-CuAu and BCC-CsCl...
Signaling cascades are crucial for transducing stimuli in biological systems, enabling multiple to regulate a downstream target with precisely controlled timing and amplifying signals through series of intermediary reactions. Developing robust signaling system such capabilities would be pivotal programming complex behaviors synthetic DNA-based molecular devices. However, although "software" as nucleic acid circuits could potentially harnessed relay nanostructure hardware, explorations have...
Sophisticated statistical mechanics approaches and human intuition have demonstrated the possibility to self-assemble complex lattices or finite size constructs, but mostly only been successful in silico. The proposed strategies quite often fail experiment due unpredicted traps associated kinetic slowing down (gelation, glass transition), as well competing ordered structures. An additional challenge that theoretical predictions face is difficulty encode desired inter-particle interaction...