A5002324142- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Bacteriophages and microbial interactions
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanocluster Synthesis and Applications
- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- Metal-Organic Frameworks: Synthesis and Applications
- DNA and Biological Computing
- Random Matrices and Applications
- nanoparticles nucleation surface interactions
- Advanced Materials Characterization Techniques
- Covalent Organic Framework Applications
- Monoclonal and Polyclonal Antibodies Research
- X-ray Diffraction in Crystallography
- Modular Robots and Swarm Intelligence
- Crystallography and molecular interactions
- Mercury impact and mitigation studies
- Crystallization and Solubility Studies
- Carbon dioxide utilization in catalysis
- Molecular Sensors and Ion Detection
- Metabolomics and Mass Spectrometry Studies
- Protein Structure and Dynamics
- Chemical Synthesis and Analysis
- Silk-based biomaterials and applications
Arizona State University
2018-2024
University of California, San Francisco
2022-2024
Indian Institute of Technology Madras
2018-2019
Jawaharlal Nehru Centre for Advanced Scientific Research
2012
Sophisticated statistical mechanics approaches and human intuition have demonstrated the possibility of self-assembling complex lattices or finite-size constructs. However, attempts so far mostly only been successful in silico often fail experiment because unpredicted traps associated with kinetic slowing down (gelation, glass transition) competing ordered structures. Theoretical predictions also face difficulty encoding desired interparticle interaction potential experimentally available...
A three-dimensional luminescent metal–organic framework, {Mg(DHT)(DMF)2}n (1), based on an excited-state intramolecular proton-transfer (ESIPT) responsive linker, 2,5-dihydroxyterephthalic acid (H2DHT), has been synthesized, and its desolvated microporous framework with pendent −OH groups the pore surface was exploited for binding specific sensing of metal ions via Lewis acid–base interactions. The luminescence intensity significantly quenches CuII among various s- d-block ions, highly...
Three-dimensional (3D) cages are one of the most important targets for nanotechnology. Both proteins and DNA have been used as building blocks to create tunable nanoscale a wide range applications, but each molecular type has its own limitations. Here, we report cage constructed from both protein through use covalent protein–DNA conjugates. We modified homotrimeric (KDPG aldolase) with three identical single-stranded handles by functionalizing reactive cysteine residue introduced via...
DNA tile-based assembly provides a promising bottom-up avenue to create designer two-dimensional (2D) and three-dimensional (3D) crystalline structures that may host guest molecules or nanoparticles achieve novel functionalities. Herein, we introduce new kind of tiles (named layered-crossover tiles) each consists two four pairs layered crossovers bridge helices in neighboring layers with precisely predetermined relative orientations. By providing proper matching rules for the sticky ends at...
Metal nanostructures of chiral geometry interacting with light via surface plasmon resonances can produce tailorable optical activity their structural alterations. However, bottom-up fabrication arbitrary metal precise size and morphology remains a synthetic challenge. Here we develop DNA origami-enabled aqueous solution metallization strategy to prescribe the chirality silver in three dimensions. We find that diamine silver(I) complexes coordinate bases prescribed single-stranded protruding...
Improving the precision and function of encapsulating three-dimensional (3D) DNA nanostructures via curved geometries could have transformative impacts on areas such as molecular transport, drug delivery, nanofabrication. However, addition non-rasterized curvature escalates design complexity without algorithmic regularity, these challenges limited ad hoc development usage previously unknown shapes. In this work, we develop automate application a set principles that now includes multilayer...
We report the first example of a covalently bound dimer monolayer protected atomically precise silver nanocluster [Ag25(DMBT)18]- (DMBT stands for 2,4-dimethylbenzenethiol). Covalently linked dimers could be important to design new cluster assembled materials with composite properties.
The combination of multiple orthogonal interactions enables hierarchical complexity in self-assembled nanoscale materials. Here, efficient supramolecular polymerization DNA origami nanostructures is demonstrated using a multivalent display small molecule host-guest interactions. Modification strands with cucurbit[7]uril (CB[7]) and its adamantane guest, yielding complex an affinity order 10
[Au25(SR)18]− nanoclusters have been tested as a model catalyst in multiple oxidation reactions involving CO, alkenes, cyclohexane, and alcohols. Oxygen is used an oxidizing agent most of the reactions. Hence, O2 activation great interest catalysis. The mechanism these reactions, role intact catalytically active species, utility such homogeneous catalysts are not completely clear. Herein, we investigate interaction solution with using electrospray ionization mass spectrometry density...
We present here the combination of experimental and computational modeling tools for design characterization protein-DNA hybrid nanostructures. Our work incorporates several features in these nanostructures: (1) linker identity length; (2) optimizing cages to account mechanical stresses; (3) probing incorporation efficiency conjugates into DNA The were experimentally validated using structural methods like cryo-TEM AFM. method can be used fitting low-resolution electron density maps when...
Integrating proteins with DNA nanotechnology would enable materials diverse applications in biology, medicine, and engineering. Here, we describe a method for incorporating bioactive fibronectin domain nanostructures using two orthogonal coiled-coil peptides. One peptide from each pair is attached to origami cuboid multivalent fashion by attaching the peptides handles. These structures can then be assembled into one-dimensional arrays through addition of linker genetically fused...
Sophisticated statistical mechanics approaches and human intuition have demonstrated the possibility to self-assemble complex lattices or finite size constructs, but mostly only been successful in silico. The proposed strategies quite often fail experiment due unpredicted traps associated kinetic slowing down (gelation, glass transition), as well competing ordered structures. An additional challenge that theoretical predictions face is difficulty encode desired inter-particle interaction...