A5051052778- Biochemical effects in animals
- Child and Adolescent Health
- Antioxidants, Aging, Portulaca oleracea
- Sepsis Diagnosis and Treatment
- Health and Medical Studies
- Advanced Glycation End Products research
- Vitamin D Research Studies
- Vitamin C and Antioxidants Research
- Human Health and Disease
- Diet, Metabolism, and Disease
- Cardiac, Anesthesia and Surgical Outcomes
- Reproductive Biology and Fertility
- Nosocomial Infections in ICU
- Immune Cell Function and Interaction
- Biochemical Acid Research Studies
- Childhood Cancer Survivors' Quality of Life
- Healthcare Systems and Public Health
- Sperm and Testicular Function
- Ovarian function and disorders
- Phytoestrogen effects and research
- Nitric Oxide and Endothelin Effects
- Acute Kidney Injury Research
- Diet and metabolism studies
- Clinical Laboratory Practices and Quality Control
- Infections and bacterial resistance
Maltepe University
2016-2024
Istanbul Medipol University
2024
Istanbul University
2011-2018
Medizinische Hochschule Hannover
2015
Istanbul University-Cerrahpaşa
2013
Human serum albumin, a negative acute phase reactant and marker of nutritive status, presents at high concentrations in plasma. Albumin has always been used many clinical states especially to improve circulatory failure. It showed that albumin is involved bioactive functions such as regulation plasma osmotic pressure, binding transport various endogenous or exogenous compounds, finally extracellular antioxidant defenses. Molecules like transferrin, caeruloplasmin, haptoglobin, uric acid,...
It has been reported that d-galactose administration causes an increase in oxidative and osmotic stresses several tissues of rodents. In this study, we established a brain ageing model by using investigated the concentrations stress markers on hippocampus, parietal frontal lobes male Sprague-Dawley rats. A mimetic was injecting (60 mg/kg/day/i.p.) experimental group for 42 days. At end period, tested spatial memory Morris water maze test. To investigate magnitude damage proteins, lipids DNA,...
Oxidative damage parameters in renal tissues of aged and young rats based on gender Duygu Uzun,1 Gülcan Güntas Korkmaz,2 Mustafa Erinç Sitar,3 Tamer Cebe,4 Karolin Yanar,3 Ufuk Çakatay,3 Seval Aydin3 1Istanbul University, Istanbul Faculty Medicine, Istanbul, Turkey; 2Kirklareli School Health, Kirklareli, 3Istanbul Cerrahpasa Department Medical Biochemistry, 4Istanbul University Turkey Purpose: Aging is characterized by a gradual functional decrease all systems including the kidneys. Growing...
Obesity has recently been mentioned as a metabolic pandemic in developed and developing countries is an important known risk factor for type 2 diabetes cardiovascular diseases. The main mechanism responsible obesity insulin resistance. Adropin peptide-structured regulatory hormone that suggested to play role resistance regulation. We aimed evaluate the associations of serum adropin with clarify factors affecting concentrations. study included 50 obese patients 22 healthy controls. Patients...
To examine whether the D-galactose induced aging model is an appropriate for further research.Experimental study.Aziz Sancar Institute of Experimental Medicine, Istanbul University, Turkey, June 2015- 2017.The study comprises 3 groups rats. Group I young control (YC) 5-month-old II 5-month- old rats, which were mimetically aged (MA) 6 weeks via intraperitoneal (60 mg/kg body weight/day, 0.5 mL) administration. III naturally (NA) 24-month-old and received saline (0.9% as vehicle. injections...
A redox basis of the increased oxidative protein damage and free radical-mediated desialylation have not been fully elucidated in aging. It is well known that incidence several liver diseases increase with age. This original research focuses on oxidation mechanisms protein-bound sialic acid levels tissue mimetic aging rats. Injection D-galactose (60 mg/kg/day) for six weeks to male Sprague-Dawley rats (20-week-old) used establish model. We investigated various markers such as carbonyl...
Background For Coronavirus Disease 2019 (Covid-19) infection, clinical laboratories provide essential contributions in the diagnosis of stage prognostication, and evaluation disease severity. We aimed to show laboratory problems including changes test numbers, panels, differences preanalytical errors during Covid-19 pandemic and, current study, we also intended give solutions for obstacles guide other possible pandemics. Methods Our study was based on data between January 10, 2020, May 2020....
Introduction Ralstonia spp. are nonfermenting gram-negative bacteria that have recently emerged as opportunistic pathogens. Previously, two case series of infection associated with insidiosa been published. In this report, R. a neonate in the neonatal intensive care unit (NICU) is presented. Case Presentation A term male infant developed respiratory distress 2 hours after birth and was admitted to NICU presumptive diagnosis transient tachypnea newborn. left apical pneumothorax detected,...
Chemotherapeutic agents used in the treatment of testicular cancer cause damage to healthy tissues, including testis. We investigated effects glutathione on sperm DNA integrity and histomorphology bleomycin etoposide cisplatin (BEP) treated rats. Twelve-week-old male rats reproductive age (n = 24) were randomly divided into three groups, (i) control group, (ii) BEP (iii) BEP+ group. Weight gain increase testes indices group found be higher than that While increased fragmentation...
One of the most important side effects contrast pharmaceutical agents, which are used very common in routine radiology practice, is induced nephropathy. Even ischemia, oxidative stress and osmolality related cytotoxic considered, molecular mechanisms underlying this pathology have not been identified completely yet.The aim current study was to reveal role antioxidant enzymatic defence aetiopathogenesis contrast-induced We also studied possible alleviating N-acetylcysteine (NAC), a potent...
Objectives: Sepsis is a complex and lethal condition.For successful treatment, clinicians need high quality testing to guide the approach pathogen identification treatment.Medical laboratories play vital role in detection of infectious agents, must continually strive discover new reliable tests analyze reliability existing different diseases expand their usage as appropriate.Selecting appropriate therapy, reducing use antibiotics thereby antibiotic resistance are also undeniable parts this...
Background: Vitamin D deficiency is a significant global health concern. Experimental models are essential to elucidate the biochemical, histopathological, and immunological consequences of this deficiency. This study established vitamin rat model mimic insufficient intake examine resulting impacts, particularly on liver, kidney, immune functions. Materials methods: Sprague-Dawley male rats were randomly assigned two groups. The control group received standard rodent diet, while experimental...
Amaç: Progesteron, adrenal bezler ve yumurtalıklar tarafından sentezlenen, yapısal olarak birçok farklı hormonun da öncüsü olan bir sinyal molekülüdür. D vitamini ise diğer vitaminlerden ekzojen alımın yanında endojen sentezlenebilen ancak eksiklik durumu güncel tıp dünyasında büyük tartışmalara neden steroid yapıda hormondur. Bu çalışmada amaç, progesteronun HepG2 hücre proliferasyonu karaciğer enzim aktivitelerine etkisini belirlemek, ayrıca vitamininin oluşturduğu sitotoksik etkileri...
Immature oocytes are retrieved and matured through in vitro maturation (IVM). Maturation, fertilization rates, embryo development via IVM all lower than those found (IVF) cycles. We investigated the effects of oncostatin M (OSM), insulin-like growth factor-1 (IGF-I), hormone (GH) rescue IVM. A total 111 germinal vesicle (GV) 17 metaphase I (MI) were obtained after conventional IVF from 28 female Wistar albino rats. Denuded immature cultured medium supplemented with OSM, IGF-1, or GH. The...
Antecedentes / objetivo : La muerte celular autofágica y la apoptosis de células tumorales se ha convertido en uno los principales objetivos el tratamiento del cáncer, mientras que las líneas celulares utilizan principalmente estudios para proporcionar datos importantes evaluación posibles sustancias anticancerígenas. En este estudio, nuestro fue evaluar cambios morfológicos bioquímicos, incluida tasa niveles alfa fetoproteína (AFP) a diferentes concentraciones ácido carnósico (CA) carcinoma...