It has been reported that d-galactose administration causes an increase in oxidative and osmotic stresses several tissues of rodents. In this study, we established a brain ageing model by using investigated the concentrations stress markers on hippocampus, parietal frontal lobes male Sprague-Dawley rats. A mimetic was injecting (60 mg/kg/day/i.p.) experimental group for 42 days. At end period, tested spatial memory Morris water maze test. To investigate magnitude damage proteins, lipids DNA,...

Albumin represents the predominant circulating antioxidant agent in plasma exposed to continuous oxidative stress and a change serum albumin structure accounts for its properties. Alterations redox status of may result impairments biological Alpha‐lipoic acid (LA), naturally occurring thiol compound found virtually all species, is potent with high efficacy which also involved chelation metal ions, regeneration antioxidants, repair oxidatively damaged proteins. In human body LA rapidly...

The aim of this study was to evaluate prolidase activity and oxidative stress in patients with oral lichen planus (OLP) lichenoid contact reactions (OLCR) using serum salivary samples compare these biomarkers each other as well a group healthy subjects order be able opine their role the estimation OLP OLCR.Eighteen recently diagnosed OLP, 32 OLCR 18 controls matched periodontal status were recruited study. Prolidase activity, lipid peroxidation product malondialdehyde (MDA), sialic acid...

Accumulation of oxidized proteins and impaired antioxidant system have been shown to be associated with arthritis. Serum sialic acid (SA) is known as a parameter inflammation. In the present study, explore potential role SA in arthritis, we measured serum levels, plasma protein oxidation, status patients primary osteoarthritis (POA) inactive rheumatoid arthritis (RA). Inactive RA (iRA) was defined upon American College Rheumatology criteria for clinical remission RA. A total 40 (20 POA...

Diabetes mellitus (DM) causes debilitating complications and, as a result, diabetics frequently require intensive care. Although lungs are not thought to be affected primarily by DM, an increasing number of studies indicate physiological and structural abnormalities in diabetic lungs.Pyrrolidine dithiocarbamate (PDTC) is metal chelator potent inhibitor NF-kappaB. Keeping mind that NF-kappaB activation may crucial end-organ injury due we studied the role PDTC on inhibition its effects...

Chronic ethanol administration is able to induce an oxidative stress in the central nervous system. N-Acetylcysteine (NAC) has antioxidant properties; as a sulphydryl donor, it contributes regeneration of glutathione and acts through direct reaction with hydroxyl radicals. In this study we investigated possible beneficial effect NAC on some free radical related parameters. Twenty four male Wistar rats were divided three groups given (Group 1), 2) isocaloric dextrose 3). Ethanol...

In this study, our aim was to determine whether or not type 1 diabetes mellitus affects salivary sialic acid level and SOD activity. For purpose, unstimulated saliva specimen collected. Saliva activity were measured by the methods of Warren Sun, respectively. We found significantly decline in The decrease may be due changes activities enzymes taking part synthesis catabolism acid. main reason for increased glycation enzyme and/or deleterious effect free oxygen radicals glycated proteins on...

Thyroid hormones are associated with the oxidative and antioxidative status of organism. Depression metabolism by hypothyroidism has been reported to decrease oxidant production thus protect tissues against damage. The purpose present study was investigate Zn Cu levels in MMI-induced show whether there is a connection between these trace elements oxidant-antioxidant experimental hypothyroidism. 3-Nitrotyrosine measured as marker nitro-oxidative stress. In order examine antioxidant rats, GSH...

Although nuts are typically high in dietary fat, novel studies have shown that regular consumption of these heart-healthy foods might confer a beneficial effect on cardiovascular disease risk. In the present study, we aimed to analyse effects pistachio blood lipids, antioxidant activity, oxidative stress and sialic acid levels high-fat-fed rats for 8 weeks. The oxidant-antioxidant status was evaluated by determination lipid peroxidation (thiobarbituric acid-reactive substances), total...

A redox basis of the increased oxidative protein damage and free radical-mediated desialylation have not been fully elucidated in aging. It is well known that incidence several liver diseases increase with age. This original research focuses on oxidation mechanisms protein-bound sialic acid levels tissue mimetic aging rats. Injection D-galactose (60 mg/kg/day) for six weeks to male Sprague-Dawley rats (20-week-old) used establish model. We investigated various markers such as carbonyl...

We aimed to test our hypothesis that scavenging reactive oxygen species (ROS) with tempol, a membrane permeable antioxidant, affects the type and magnitude of oxidative damage stress tolerance through mimetic aging process in Drosophila. Drosophila colonies were randomly divided into three groups: (1) no d ‐galactose, tempol; (2) ‐galactose without (3) but tempol. Mimetic was induced by administration. The tempol‐administered flies received tempol at concentration 0.2% addition ‐galactose....

Objective: The aim of this study was to investigating the effects infl iximab in severe necrotizing pancreatitis.Methods: Forty male Wistar rats were randomly divided into fi ve groups evenly.Necrotizing pancreatitis induced group I and II by retrograde injection 3% taurocholate common pancreaticobiliary duct.In III IV saline introduced instead mimic pressure effect.Infl (8mg/kg) infused through tail vein just before laparotomy.Group V underwent sham laparotomy.Serum amylase activity, serum...

Recombinant human growth hormone and nandrolone phenylpropionate are two different anabolic agents. This study was designed to investigate the effects of these agents on healing ischemic colon anastomosis in rats.Seventy adult male Wistar rats were divided into five groups (n = 14). Group I sham laparotomy group. In other groups, surgical procedures consisting transsection made at a distance 3 cm from peritoneal reflection. II nonischemic control Ischemic model produced remaining groups. III...

AIM: Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells.Increased ADM level has been linked to hyperdynamic circulation arterial vasodilatation cirrhotic portal hypertension (CPH).The role of non-cirrhotic (NCPH) unknown.plasma levels were studied patients with NCPH, compensated decompensated cirrhosis order determine its contribution (PH) these groups.METHODS: There 4 groups subjects.Group 1 consisted 27 (F/M: 12/15)...

It is well known that in vitro storage lesions lead to membrane dysfunction and decreased number of functional erythrocytes. As erythrocytes get older, media as peripheral circulation, they undergo a variety biochemical changes. In our study, the with different age groups citrate phosphate dextrose adenine-formula 1 (CPDA-1) solution were used order investigate possible effect gender factor on oxidative damage. Oxidative damage biomarkers erythrocyte membranes such ferric reducing...

Sirtuin3 (SIRT3) is a NAD+-dependent major mitochondrial deacetylase. In this study, we aimed to investigate SIRT3 levels and their target enzyme activities, including glutamate dehydrogenase (GDH), succinate (SDH), manganese superoxide dismutase (MnSOD), also determine the antioxidant capacity oxidative stress in tissue, mitochondria serum samples ovarian endometrioma patients.We collected tissue from 30 patients. control group, eutopic endometrial 26 women without endometriosis.SIRT3 were...

The effects of pentoxifylline (PTX) and interferon α (IFN-α) in the prevention strictures due to corrosive esophagitis rats were investigated. Forty randomly divided into four equal groups. Corrosive was induced all groups by application 37.5% NaOH distal esophagus for a period 90 s followed saline rinse. Histopathologic damage significantly lower PTX IFN-α-treated than untreated group. During study period, INF-α-treated animals showed significant increase body weight when compared controls....