A5009564078- Salivary Gland Disorders and Functions
- Pharmacological Effects and Toxicity Studies
- Effects and risks of endocrine disrupting chemicals
- Oral microbiology and periodontitis research
- Zebrafish Biomedical Research Applications
- Histone Deacetylase Inhibitors Research
- Biochemical effects in animals
- Neuroinflammation and Neurodegeneration Mechanisms
- Fluoride Effects and Removal
- Nuts composition and effects
- Cholinesterase and Neurodegenerative Diseases
- Reproductive System and Pregnancy
- Toxic Organic Pollutants Impact
- Diet and metabolism studies
- Birth, Development, and Health
- Surgical Sutures and Adhesives
- Parkinson's Disease Mechanisms and Treatments
- Molecular Biology Techniques and Applications
- Environmental Toxicology and Ecotoxicology
- MicroRNA in disease regulation
- Sulfur Compounds in Biology
- Sirtuins and Resveratrol in Medicine
- Carcinogens and Genotoxicity Assessment
- Adipose Tissue and Metabolism
- Hemostasis and retained surgical items
Marmara University
2015-2024
Dr. A. Ramachandran's Diabetes Hospitals
2024
Advanced Neural Dynamics (United States)
2020
Maltepe University
2017-2020
Istanbul University
2016-2017
İstanbul Nişantaşı Üniversitesi
2007-2015
Military Medical Academy
2010
Background: This study evaluates the effects on clinical and biochemical parameters of Lactobacillus reuteri –containing probiotic supplementation adjunctive to initial periodontal therapy in patients with chronic periodontitis (CP). Methods: Thirty CP were included divided into two groups. Every patient had, each quadrant, ≥2 teeth approximal sites a probing depth (PD) 5 7 mm gingival index (GI) ≥2. The test group received scaling root planing (SRP) probiotic‐containing lozenges. control...
Abstract Objectives The putative protective effects of resveratrol against oxidative injury in the heart, kidney and brain tissues rats induced with two-kidney, one-clip (2K1C) hypertension model were investigated. Methods Wistar albino divided into sham-operated (n = 8) or 2K1C groups, which received either (10 mg/kg per day, i.p., n 8), saline starting at Week 3 after surgery continuing for following 6 weeks. Indirect blood pressure recordings echocardiographic images made to evaluate...
Introduction: Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric condition characterized by intrusive obsessions and repetitive compulsions, significantly impairing daily functioning the quality of life. Increasing evidence suggests that oxidative stress may play an important role in pathophysiology OCD, but biochemical mechanisms underlying this relationship require further elaboration. This study aims to investigate oxidant-antioxidant status OCD patients compared healthy...
The effect of melatonin was investigated in an angiotensin II-dependent renovascular hypertension model Wistar albino rats by placing a renal artery clip (two-kidney, one-clip; 2K1C), while sham did not have placement. Starting either on the operation day or 3 wk after operation, received (10 mg/kg/day) vehicle for following 6 wk. At end nineth week, blood pressure (BP) and echocardiographic recordings were obtained, plasma samples obtained to assay lactate dehydrogenase (LDH), creatine...
Aim: The aim of this study is to investigate the possible protective effects mitoquinone and oleandrin on rotenone induced Parkinson's disease in zebrafish. Materials methods: Adult zebrafish were exposed for 30 days. Biochemical parameters determined by spectrophotometric method disease-related gene expressions reverse transcription polymerase chain reaction method. Measurement neurotransmitters was performed liquid chromatography tandem-mass spectrometry instrument. accumulation synuclein...
Abstract Methylparabens (MP) are widely used as preservatives in cosmetics, pharmacy, and food industry. Although acute toxicity studies animals indicated that parabens not significantly toxic, the effects of chronic exposure under sublethal doses still unknown number related is limited. Our aim was to evaluate MP on development zebrafish embryos focusing development, locomotor activity, oxidant–antioxidant status, apoptosis, ccnd1 myca expressions. The expressions were determined by RT‐PCR....
Rotenone is a commonly used pesticide that inhibits complex I of the mitochondrial electron transport system. exposed rats demonstrate many characteristics Parkinson Disease (PD). Oxidative stress one hallmarks PD, being major sources ROS in DA neurons. In recent years strong connection between intestinal environment and function central nervous system (CNS) has gained widespread popularity. order to explain mechanism underlying GI dysfunction we aimed investigate oxidant-antioxidant status...
Among the mechanisms underlying Parkinson's disease, many pathogenic are suggested to be effective such as oxidative stress, mitochondrial dysfunction, disruption of ubiquitin-proteasome system, and neuroinflammation. Calcium is very important for neuronal glial cells, neurodegenerative disease closely related disturbed calcium homeostasis. Recent studies strongly support role inflammation in nigrostriatal degeneration PD. In recent years, Rifampicin, a macrocyclic antibiotic has been shown...
Breast cancer is the most common in women living Western world, even though it occurs worldwide. Cancer and therapy induce multiple oral complications including dental periodontal disease. Saliva a complex dynamic biologic fluid, which reflects both systemic changes. While saliva easily accessible body there has been little effort to study its value diagnosis. Sialic acids (SA), end moieties of carbohydrate chains, are biologically important essential for functions glycoconjugates that...
Accumulation of oxidized proteins and impaired antioxidant system have been shown to be associated with arthritis. Serum sialic acid (SA) is known as a parameter inflammation. In the present study, explore potential role SA in arthritis, we measured serum levels, plasma protein oxidation, status patients primary osteoarthritis (POA) inactive rheumatoid arthritis (RA). Inactive RA (iRA) was defined upon American College Rheumatology criteria for clinical remission RA. A total 40 (20 POA...
Polyethylene terephthalate (PET) and polycarbonate (PC) are the most commonly used plastics in water bottles. Di(2-ethylhexyl) phthalate (DEHP) is as a plasticizer PET plastics, bisphenol A (BPA) to produce PC. Both DEHP BPA known for their potential endocrine disrupting effects. The Wnt/β-catenin signaling pathway has important roles cell proliferation, specification fate determination during embryonic development. Recent reports suggest link between apoptosis. aim of this study was...
Disruption of the gut-brain axis in Parkinson's disease (PD) may lead to motor symptoms and PD pathogenesis. Recently, neuroprotective potential different PPARδ-agonists has been shown. We aimed reveal effects erucic acid, peroxisome proliferator-activated receptors (PPARs)-ligand rotenone-induced model zebrafish, focusing on axis. Adult zebrafish were exposed rotenone acid for 30 days. Liquid chromatography-mass spectrometry tandem mass (LC-MS/MS) analysis was performed. Raw files analysed...
Abstract Background Tissue factor (TF) is considered to be a major regulator of normal haemostasis and thrombosis. Circulating TF activity suggested associated with diabetes mellitus. Various tissues body fluids have activity. The aim the present study was investigate streptozotocin (STZ) induced diabetic rat tissues. Peanut consumption reported decreased risk type 2 diabetes. Therefore, effect peanut on STZ tissues, haemostatic parameters such as protrombin time (PT), activated partial...
The aim of this study is to evaluate the effect these new generation hemostatic agents on early-stage soft tissue healing warfarin-treated rats by measuring factor (TF) activities. Rats in warfarin group were treated intraperitonally with 0.1 mg/kg warfarin, and control 1 mL/kg saline. All had 3 incisions dorsal dermal applied Celox, Ankaferd Blood Stopper (ABS), or no agent. Six from each killed day 4, other 6 8. Prothrombin time (PT) TF activities evaluated, respectively. Both positively...