A5088287889- Zebrafish Biomedical Research Applications
- Peroxisome Proliferator-Activated Receptors
- Neuroinflammation and Neurodegeneration Mechanisms
- Effects and risks of endocrine disrupting chemicals
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Birth, Development, and Health
- Neurological Disease Mechanisms and Treatments
- Molecular Biology Techniques and Applications
- Environmental Toxicology and Ecotoxicology
- Sirtuins and Resveratrol in Medicine
- Pharmacological Effects and Toxicity Studies
- Effects of Radiation Exposure
- Aquaculture Nutrition and Growth
- Neuroscience and Neuropharmacology Research
- Biochemical Analysis and Sensing Techniques
- Cholinesterase and Neurodegenerative Diseases
- Congenital heart defects research
- Calpain Protease Function and Regulation
- Parkinson's Disease Mechanisms and Treatments
- RNA Research and Splicing
- Child Welfare and Adoption
- Autophagy in Disease and Therapy
- Ultrasound and Hyperthermia Applications
- Pharmacological Receptor Mechanisms and Effects
Istanbul Medipol University
2022-2024
Marmara University
2024
Istanbul University-Cerrahpaşa
2020-2023
Introduction: Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric condition characterized by intrusive obsessions and repetitive compulsions, significantly impairing daily functioning the quality of life. Increasing evidence suggests that oxidative stress may play an important role in pathophysiology OCD, but biochemical mechanisms underlying this relationship require further elaboration. This study aims to investigate oxidant-antioxidant status OCD patients compared healthy...
Disruption of the gut-brain axis in Parkinson's disease (PD) may lead to motor symptoms and PD pathogenesis. Recently, neuroprotective potential different PPARδ-agonists has been shown. We aimed reveal effects erucic acid, peroxisome proliferator-activated receptors (PPARs)-ligand rotenone-induced model zebrafish, focusing on axis. Adult zebrafish were exposed rotenone acid for 30 days. Liquid chromatography-mass spectrometry tandem mass (LC-MS/MS) analysis was performed. Raw files analysed...
Parkinson's disease (PD) is one of the most common neurodegenerative diseases due to loss dopaminergic neurons in midbrain substantia nigra. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) a neurotoxic agent causing disruptions mitochondria leading impaired oxidant-antioxidant balance. Both zebrafish and embryos are sensitive MPTP. In embryos, MPTP decreases cells diencephalon by damaging neurons. Morphine an opioid pain killer strong analgesic that used treat chronic pain. Until today...
Obesogens affect lipid metabolism, and genetic or epigenetic factors may also contribute to the progression of obesity. Endocrine-disrupting chemicals (EDCs) are most striking among obesogens. Bisphenol A (BPA) is an estrogenic EDC used in food containers, adhesives, dye powders, dental fillers. We aimed elucidate molecular mechanisms BPA's obesogenic effects focusing on pathways liver including fibroblast growth factor (FGF) Dnmt3a which its regulator, oxidant-antioxidant status,...
Rotenone is used to generate Parkinson's disease (PD)-like symptoms in experimental animals. Octanoic acid (C8), the principal fatty of medium-chain triglycerides ketogenic diets. Beneficial effects diets were shown PD. We applied proteomic methods reveal octanoic rotenone toxicity zebrafish gain information on use Zebrafish exposed 5 μg/ml and (20 60 mg/ml) for 30 days. LC-MS/MS analysis was performed. Raw files analyzed by Proteome Discoverer 2.4 software, peptide lists searched against...
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that damages dopaminergic neurons. Zebrafish has been shown to be suitable model organism investigate the molecular pathways in pathogenesis of Parkinson's disease and also for potential therapeutic agent research. Boron play an important role neural activity brain. Boronic acids are used combinatorial approaches drug design discovery. The effect 3-pyridinylboronic acid which sub-class heterocyclic boronic not evaluated case...
We aimed to evaluate how different types of toothpaste (TP) for children affected molecular mechanisms odontogenesis in zebrafish embryos. Commercially available TPs were selected according their detergent contents as the cocamidopropyl betaine (CAPB) containing TP (TP1) and sodium lauryl sulfate (SLS) (TP2). TP3 contained no detergent. Effects SLS, CAPB alone also examined. concentrations affecting development determined 750 mg/L 4 mg/L, respectively. Embryos exposed TP1, TP2, TP3, CAPB,...
Salicylic acid topical is used to treat variety of skin conditions. However, salicylic in these products generated through industrial synthesis and has been shown negatively impact fetal development cause congenital abnormalities. We hypothesized that teratogenic effects reported can be prevented by naturally synthesizing from wintergreen oil using green chemistry method. For this purpose, we investigated the natural (NSA) synthesized synthetic (SSA) on keratinocyte cell (HaCaT)...
Ketosis is a potentially beneficial metabolic state for health especially in neurological conditions including Parkinson's disease (PD). Medium-chain-triglycerides (MCT) have specific properties and they are described as ketogenic even without restriction of carbohydrate. Octanoic acid (C8) the main MCT showing this effect. Rotenone neurotoxin that used to induce experimental PD model. inhibits mitochondrial respiratory complex 1 (MRC1) causes reactive oxygen species formation. Mass...
Objective: As an anionic surfactant, sodium lauryl sulphate (SLS), is used as emulsifying agent in toothpastes well many different household cleaning products. Many contain SLS and it responsible for the formation of foam when brushing. However may also irritate sensitive teeth gums. Lipid peroxidation (LPO) defined autoxidation process that induced through attack free oxygen radicals leading to oxidative stress pathophysiology various diseases. LPO causes highly reactive products including...
Prenatal exposure to environmental factors may play an important role in the aetiopathogenesis of autism spectrum disorder (ASD). We aim investigate potential effects low-dose x-rays from dental diagnostic on neurodevelopment and molecular mechanisms associated with ASD developing zebrafish embryos. Zebrafish embryos were divided into four groups exposed using a x-ray unit: control, 0.08, 0.15 0.30 seconds, which are exemplary settings for periapical imaging. These times measured as 7.17,...
Exposure of zebrafish embryos to glucose is a suitable model for the fetal hyperglycemia seen in gestational diabetes. Diethylhexyl phthalate (DEHP), which considered an endocrine-disrupting chemical, one most common derivatives used stretching plastic and encountered every area where daily life. In present study, effects DEHP on pathways related insulin resistance obesity were examined exposed as model. Zebrafish DEHP, glucose, + 72 h post-fertilization (hpf), developmental parameters...