A5055039621- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Advanced Proteomics Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Mass Spectrometry Techniques and Applications
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- COVID-19 Impact on Reproduction
- Fungal Biology and Applications
- Pregnancy and Medication Impact
- Cancer, Lipids, and Metabolism
- Optimism, Hope, and Well-being
- Genetic factors in colorectal cancer
- Dermatoglyphics and Human Traits
- Aquaculture Nutrition and Growth
- Neuroinflammation and Neurodegeneration Mechanisms
- Molecular Biology Techniques and Applications
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- Lipid metabolism and biosynthesis
- RNA and protein synthesis mechanisms
- Zebrafish Biomedical Research Applications
- Metabolism, Diabetes, and Cancer
- Connexins and lens biology
Istanbul University
2020-2024
Sağlık Bilimleri Üniversitesi
2022-2024
University of Health Sciences Antigua
2023
HUN-REN Institute of Experimental Medicine
2020
Orient-Institut Istanbul
2020
Disruption of the gut-brain axis in Parkinson's disease (PD) may lead to motor symptoms and PD pathogenesis. Recently, neuroprotective potential different PPARδ-agonists has been shown. We aimed reveal effects erucic acid, peroxisome proliferator-activated receptors (PPARs)-ligand rotenone-induced model zebrafish, focusing on axis. Adult zebrafish were exposed rotenone acid for 30 days. Liquid chromatography-mass spectrometry tandem mass (LC-MS/MS) analysis was performed. Raw files analysed...
Rotenone is used to generate Parkinson's disease (PD)-like symptoms in experimental animals. Octanoic acid (C8), the principal fatty of medium-chain triglycerides ketogenic diets. Beneficial effects diets were shown PD. We applied proteomic methods reveal octanoic rotenone toxicity zebrafish gain information on use Zebrafish exposed 5 μg/ml and (20 60 mg/ml) for 30 days. LC-MS/MS analysis was performed. Raw files analyzed by Proteome Discoverer 2.4 software, peptide lists searched against...
Ketosis is a potentially beneficial metabolic state for health especially in neurological conditions including Parkinson's disease (PD). Medium-chain-triglycerides (MCT) have specific properties and they are described as ketogenic even without restriction of carbohydrate. Octanoic acid (C8) the main MCT showing this effect. Rotenone neurotoxin that used to induce experimental PD model. inhibits mitochondrial respiratory complex 1 (MRC1) causes reactive oxygen species formation. Mass...
Mitogen-activated protein kinases (MAPKs) are important regulatory molecules, which have essential roles in physiology and pathology. In the present study, we examined possible correlation between MAPK7 gene colorectal cancer risk Turkish population.A total of 100 human DNA samples (50 patients 50 healthy individuals) were sequenced using next-generation sequencing to define potential genetic variations gene.Five (MAPK7; rs2233072, rs2233076, rs181138364, rs34984998, rs148989290) detected...
Objective: Type 2 diabetes mellitus (T2D) is a metabolic disease whose molecular events have not yet been fully clarified.However, nextgeneration powerful approaches such as mass spectrometry (MS)-based proteomics holds promise.In this study, we aimed to reveal the protein profile of serum samples obtained from patients with T2D and atherosclerotic cardiovascular using highresolution liquid chromatography (LC)-MS/MS system. Materials Methods:Immune depletion was performed for top 12 abundant...
Abstract Objectives The accumulation of genetic damages in onset cancer induce activation protooncogenes or inactivation tumor suppressor genes thus cause disruption the balance between cell proliferation and programmed death. As a member apoptosis inhibitory protein family (IAP), survivin play important roles carcinogenesis process. evidence suggests that polymorphisms located promoter region may be determining susceptibility cancer. In this study, we aimed to examine possible role −31 −625...
Objective: Dysregulation of cellular adhesion is one the main mechanisms responsible for tumor initiation, proliferation, and survival. E-cadherin a cell molecule associated with tissue invasion metastasis in most epithelial cancers. Gap junctions are known as small molecular channels that allow communication between neighboring cells consist connexin molecules. Connexin 43 (Cx43) gap junction protein plays central role cell-cycle regulation has an important function carcinogenesis. The...
Abstract Objectives Genetic variations of LGALS3 (Galectin-3) were found to be associated with treatment resistance, mortality, recurrence, high tumor volume and multiple involvement in solid organ cancers. The modulators extracellular matrix (ECM), which is a dynamic factor the larynx tissue biomechanical regenerating ability, can play an important role. We aimed investigate relationship between genetic variants LGALS3, one these modulators, Laryngeal Squamous Cell Carcinoma (LSCC). Methods...
Abstract Objectives Apoptosis is defined as programmed cell death, which regulates cellular functions and various physiological responses. Several studies reported that Caspase genes play important roles in the apoptosis inflammation process. Caspase-8 (CASP8) a member of cysteine protease family key regulator gene induction apoptosis. In present study, we aimed to investigate possible associations between CASP8; D302H (G>C) polymorphism colorectal cancer risk prognosis. Methods The CASP8...
Objective: Pregnancy is a process in which not only physical changes occur, but also immune responses are modulated.Therefore, pregnant women more susceptible to viral infections due these during the pregnancy.The present study aimed evaluate hematological and biochemical parameters of diagnosed with infection. Materials Methods:The groups consisted cytomegalovirus (CMV), hepatitis B virus (HBV), influenza, Covid-19 healthy as control group.The data total 522 were analyzed...
Proteomic studies permit the evaluation of pathological or physiological events in more detail through technological developments fields mass spectrometry and chromatography. Protein phosphorylation, an important research area spectrometry-based proteomic studies, plays active role as a dynamic marker molecular activity alteration cellular processes. Therefore, phosphoproteomic are gaining importance elucidation mechanisms diseases development effective diagnostic treatment methods....