ABSTRACT Background The underlying mechanism of quetiapine (QET) in treating cognitive impairment sleep deprivation is unclear. present study aimed to evaluate the effects treatment with QET on novel object recognition and hippocampal (hippo) brain‐derived neurotrophic factor (BDNF) levels rats submitted 72 h (SD). Materials Methods A total 42 adult male Wistar albino were assigned into six experimental groups: non‐sleep‐deprived (NSD) control, short‐term control group ( n = 7) received a...

Aging is a degenerative process. Therefore, the background of our study to evaluate effects boron, one important underground resources in Türkiye, on aging and related diseases. This aimed assess antioxidant effect cognitive functions boric acid (BA) D-galactose (D-gal)-induced model. Eight male Wistar rats, each 12 weeks old, were split into four groups at random: control, D-gal, BA D-gal+BA. An experimental model was induced by single subcutaneous injection D-gal (150 mg/kg/day), (100...

Alzheimer's disease (AD), the primary cause of dementia and fifth leading global mortality, affects 45 million people worldwide.Neurodegeneration in AD is characterized by abnormal accumulation Aβ plaques, neuritic neurofibrillary tangles, synaptic abnormalities (Hampel et al., 2021;Peng 2022).D-galactose (D-gal), a six-carbon monosaccharide found hemicellulose, pectins, gums, often used as model for studying mechanisms potential treatments (Gao 2016;Chroumpi 2022).Abnormal D-gal metabolism...

Breast cancer is the most common in women living Western world, even though it occurs worldwide. Cancer and therapy induce multiple oral complications including dental periodontal disease. Saliva a complex dynamic biologic fluid, which reflects both systemic changes. While saliva easily accessible body there has been little effort to study its value diagnosis. Sialic acids (SA), end moieties of carbohydrate chains, are biologically important essential for functions glycoconjugates that...

Abstract Background Tissue factor (TF) is considered to be a major regulator of normal haemostasis and thrombosis. Circulating TF activity suggested associated with diabetes mellitus. Various tissues body fluids have activity. The aim the present study was investigate streptozotocin (STZ) induced diabetic rat tissues. Peanut consumption reported decreased risk type 2 diabetes. Therefore, effect peanut on STZ tissues, haemostatic parameters such as protrombin time (PT), activated partial...

The chemical and physical characteristics of several flavonoid compounds such as geraniol, thymoquinone, betaine, apigenin, N-acetylcysteine, catechin, l -carnosine, epigallocatachin, saponarin were examined in this work. Numerous molecular properties all used study calculated using the Calculate Molecular Properties module Accelrys Discovery Studio v20.1.0.19295.0. These included polar surface area, total solvent accessible heat formation. We MCNPX general-purpose Monte Carlo code...

Abstract The aim of this investigation was to assess the influence peanut ( Arachis hypogaea ) consumption on oxidant‐antioxidant status and lipid profile in Streptozotocin (STZ) induced diabetic rats. 32 rats were divided into 4 groups as control, control+peanut, diabetic, diabetic+peanut. Control fed standard rat chow whereas control+peanut diabetic+peanut supplemented with 0.63 g % for 12 weeks. Serum glucose levels, lipids, Glutathione (GSH), peroxidation (LPO) atherogenic index (AI)...

Abstract Saliva samples are often required to be stored for longer periods of time either because the project protocol or lack funding analysis. The effects 6 months storage (fresh, 30, 60, 90 120, 150, and 180 d) on stability salivary reduced glutathione (GSH), lipid peroxidation (LPO) days 15, tissue factor (TF) activity saliva imprint at −20°C were evaluated in this study. Salivary GSH, malondialdehyde (MDA) levels as an index LPO, TF activities determined using methods Beutler, Yagi,...

Saliva plays an important role in the protection of oral cavity and alterations either salivary flow rate or protein composition may have dramatic effects on health. Prevention management complications cancer therapy will improve function quality life, reduce morbidity cost care. The aim this study was to investigate saliva patients with breast biochemically cytologically compare healthy controls. Accordingly, lipid peroxidation (LPO), total protein, rate, pH levels were measured samples...

Abstract This study aimed to determine the gamma shielding parameters of an Erbium Zinc Tellurite Glass System. The mass attenuation coefficients System xEr2O3:20ZnO : (80-x) TeO2 were computed using Monte Carlo simulation at photon energies 20, 30, and 40 keV 60, 356, 662, 1,173, 1,274, 1,332 keV. half-value layer thickness was calculated coefficients. obtained results compared standard XCOM data found comparable. It that erbium zinc tellurite glass with a higher content is superior...

This study evaluates the protective effect of Hesperidin (HES), flavanoglycone, during pre-eclampsia developed pregnancy.The pregnant rats were randomly divided into five groups as Control, L-NAME (25 mg/kg), HES (100 L-NAME-HES and P-HES.After 13 th day pregnancy, chemicals administrated until 20 day.20 days after offspring's birth, they separated from their mothers all sacrificed 6 weeks' time.Serum samples analyzed for levels Glutathione (GSH), lipid peroxidation (LPO), neuron-specific...

In an aging model established using male Wistar albino rats via the administration of D-galactose (D-gal), aim this study was to examine effects chelidonic acid (CA) on cognitive function and levels glutathione (GSH), malondialdehyde (MDA), total antioxidant status (TAS), brain-derived neurotrophic factor (BDNF).

Parkinson's disease (PD) is a one of the important neurodegenerative disorders that affect dopaminergic neurons in brain. Quercetin most potent antioxidants among all flavonoids, with direct radical scavenging activities and induction antioxidative enzymes. Studies have shown boric acid essential for activity brain functions. We also used 3-month-old Wistar-albino male rats our study, experimental groups were divided into 8 (n=7) Glutathione (GSH) Malondialdehyde (MDA) levels determined...

Diabetes mellitus inhibits wound-induced angiogenesis, impairs the wound healing process, and leads to development of chronic wounds. Ankaferd BloodStopper (ABS) is a new promising local haemostatic agent. Although mechanism ABS-mediated haemostasis well established, little known about associated histological biochemical tissue reactions. The aim this study was evaluate effects new-generation agent on short-term soft-tissue in streptozotocin (STZ)-treated rats.The 24 Wistar albino rats used...

Abstract Background and Aim: There is limited evidence suggesting that nuts improve plasma antioxidant potential. The aim of this study to investigate the effects hazelnut consumption on serum lipids, atherogenic indexes oxidant-antioxidant status in hyperlipidemic-diabetic rats. Methods: Wistar-albino rats both sexes, weighing 200-250 g were used study. group animals study, which consisted 32 rats, divided into 4 groups: control, control + hazelnut, hyperlipidemic-diabetic, hazelnut....

D-Galaktoz (D-GAL), oksidatif stresi arttirarak dogal yaslanma surecini uyaran bir monosakkarittir. Bu calismada, ile iliskili hasarli modelde stres uzerine gunluk kefir tuketiminin etkisi arastirildi. Sicanlara 8 hafta boyunca D-GAL (300 mg/kg/5 gun), Dusuk doz Kefir (DKFR) (0.7 ml/kg/5 gun) ve Yuksek (YKFR) (3.5 uygulandi. sure sonunda elde edilen beyin dokusu orneklerinde Glutatyon (GSH) Lipid peroksidasyonu (LPO) duzeyleri Superoksit dismutaz (SOD) Asetilkolin esteraz (AChE) aktiviteleri...

Epilepsi dunya capinda populasyonun yaklasik %1’ini etkileyen psikolojik ve duygusal parametrelerde anlamli degisiklikler ile iliskili karmasik norolojik bir durumdur. Oksidatif stres pek cok norodejeneratif bozuklukta noronal hasari aciklamak icin kullanilan ortak yoldur Bir biyoflavonoid olan Hesperidin’in noroprotektif, antiinflamatuvar, analjezik, antibakteriyel, antihiperkolesterolemik antikanser ozelliklere sahip oldugu bildirilmistir. Calismamizda Hesperidin antiepileptik ilaclardan...