A5034328876- Veterinary Oncology Research
- Wildlife Ecology and Conservation
- Microbial infections and disease research
- Immunotherapy and Immune Responses
- Forensic Entomology and Diptera Studies
- Rabies epidemiology and control
- Veterinary Equine Medical Research
- Infectious Diseases and Mycology
- Magnesium Alloys: Properties and Applications
- Wildlife-Road Interactions and Conservation
- Veterinary Practice and Education Studies
- Species Distribution and Climate Change
- Animal Behavior and Welfare Studies
- Human-Animal Interaction Studies
- Immune Response and Inflammation
- Veterinary Medicine and Surgery
- Immune cells in cancer
- Virus-based gene therapy research
- Zoonotic diseases and public health
- Hydrogen Storage and Materials
- Entomopathogenic Microorganisms in Pest Control
- Escherichia coli research studies
- Tendon Structure and Treatment
- Venomous Animal Envenomation and Studies
- Corrosion Behavior and Inhibition
The University of Queensland
2016-2025
Australian Centre for Disease Preparedness
2019
Commonwealth Scientific and Industrial Research Organisation
2019
Westmead Hospital
2019
Pfizer (United Kingdom)
2009-2016
Suez Canal University
2014
The University of Texas MD Anderson Cancer Center
2013
Abstract Koala populations are in catastrophic decline certain eastern Australian regions. Spanning from 1997–2013, a database derived wildlife hospitals southeast Queensland with N = 20,250 entries was classified by causes of morbidity and mortality. A total 11 aetiologies were identified, chlamydiosis, trauma, wasting being most common. The clinical diagnosis at submission varied significantly over the observation period. Combinations observed 39% koalas submitted, chlamydiosis frequently...
RNA interference (RNAi) may provide a therapeutic solution to many pulmonary epithelium diseases. However, the main barrier clinical use of RNAi remains lack efficient delivery vectors. Research has mainly concentrated on intranasal route short interfering (siRNA) effector molecules for treatment respiratory this be complicated in diseased state due increased fluid production and tissue remodeling. Therefore, we investigated our hydration freeze-dried matrix (HFDM) formulated liposomes...
The calf’s gastrointestinal tract (GIT) microbiome undergoes rapid shifts during early post-natal life, which can directly affect calf performance. objectives of this study were to characterise and compare differences in the establishment succession GIT microbiota, morphological changes, growth dairy calves from birth until weaned. Forty-four newborn Holstein-Friesian randomly selected assigned Treatment (TRT) Control (CON) groups. TRT group received a once-daily dose direct-fed microbial...
Adaptation to existence outside the womb is a key event in life of mammal. The absence macrophages rats with homozygous mutation colony-stimulating factor 1 receptor ( Csf1r) gene Csf1rko ) severely compromises pre-weaning somatic growth and maturation organ function. Transfer wild-type bone marrow cells (BMT) at weaning rescues tissue macrophage populations permitting normal development long-term survival. To dissect phenotype function postnatal development, we generated transcriptomic...
Abstract Interleukin-34 (IL34) and colony stimulating factor 1 (CSF1) signal through a shared receptor (CSF1R) to control macrophage survival, differentiation function. Here we describe the impact of loss function mutation in rat Il34 gene. −/− rats showed partial reduction macrophages within squamous epithelia (Langerhans-like cells) testis. In brain, microglia brain-associated were selectively depleted grey matter. A gradient microglial density cortex suggests that CSF1 can diffuse...
Vincristine is an antineoplastic substance that part of many chemotherapy regimens, used especially for the treatment a variety pediatric cancers including leukemias and brain tumors. Unfortunately, vincristine-treated patients develop peripheral neuropathy, side effect characterized by sensory, motoric, autonomic symptoms. The sensory symptoms include pain, in particular hypersensitivity to light touch, as well loss discrimination detect vibration touch. vincristine-induced neuropathy are...
Abstract This work investigates the influence of Ag (1 wt%) on mechanical properties, in vitro and vivo corrosion, biocompatibility Fe‐35Mn. The microstructure Fe‐35Mn‐1Ag possesses a uniform dispersion discrete silver particles. Slight improvements compressive properties are attributed to enhanced density low porosity volume. exhibits good corrosion rate Fe‐35Mn due an increase microgalvanic corrosion. Gas pockets, which originate from inflammatory response implants, observed rats after 4...
ABSTRACT Trehalose 6,6′-dimycolate (TDM) is a cell wall glycolipid and an important virulence factor of mycobacteria. In order to study the role TDM in innate immune response Mycobacterium tuberculosis , microarray analysis was used examine gene regulation murine bone marrow-derived macrophages 90-μm-diameter polystyrene microspheres coated with TDM. A large number genes, particularly those involved macrophage function, were up- or downregulated these TDM-coated beads compared control beads....
Abstract Koalas are an iconic Australian marsupial undergoing precipitous population reduction in South-East Queensland from complex interacting threats. To investigate the causes of death and interaction comorbidities with demography koalas, a large scale, high-throughput prospective necropsy survey was conducted spanning 2013–2016. During this period, 519 necropsies were 155 young/subadult 235 mature, 119 old koalas 10 unknown age. Similar numbers males females assessed. Trauma infectious...
Abstract The active collection of wildlife sighting data by trained observers is expensive, restricted to small geographical areas and conducted infrequently. Reporting sightings members the public provides an opportunity collect continuously over wider areas, at lower cost. We used individual koala reported between 1997 2013 in South-East Queensland, Australia ( n = 14,076 sightings) describe spatial temporal trends presence, estimate density identify biases associated with sightings....
A magnesium alloy containing essential, non-toxic, biodegradable elements such as Ca and Zn has been fabricated using a novel twin-roll casting process (TRC). Microstructure, mechanical properties, in vivo corrosion biocompatibility have assessed compared to the properties of rare earth (RE) element WE43 alloy. TRC Mg-0.5 wt% Zn- 0.5 exhibited fine grains with an average grain size ranging from 70 150 μm. Mechanical Mg-0.5Zn-0.5Ca showed ultimate tensile strength 220 MPa ductility 9.3%. The...
: Julia Creek dunnarts are an endangered species of carnivorous marsupials and the focus multiple conservation strategies involving significant resources such as captive breeding programs. Despite relevance for conservation, no study to date has focused on evaluating geriatric diseases in dunnarts. This describes pathology findings a group one wild 35 captive-born, mostly that failed produce offspring over periods. A total 20 females 16 males were submitted postmortem examination, with ages...
Abstract Adaptation to existence outside the womb is a key event in life of mammal. The absence macrophages rats with homozygous mutation Csf1r gene ( Csf1rko ) severely compromises pre-weaning somatic growth and maturation organ function. Transfer wild-type bone marrow cells (BMT) at weaning rescues tissue macrophage populations permitting normal development long-term survival. To dissect phenotype function postnatal development, we generated transcriptomic profiles all major organs...
Background We describe intratumoral injection of a slow-release emulsion killed mycobacteria (complete Freund’s adjuvant (CFA)) in three preclinical species and human cancer patients. Methods Efficacy safety were tested mammary tumors mice, mastocytomas mice dogs, equine melanomas. In survival, tumor growth, infiltration by six immune cell subsets (by flow cytometry) investigated analyzed using Cox proportional hazards, random slopes model, full factorial respectively. Tumor growth histology...
Julia Creek dunnarts are an endangered species of carnivorous marsupials and the focus multiple conservation strategies involving significant resources such as captive breeding programs. Despite relevance for conservation, no study to date has focused on evaluating geriatric diseases in dunnarts. This describes pathology findings a group 36 captive-born, mostly that failed produce offspring over periods. A total 20 females 16 males were submitted postmortem examination, with ages ranging...
Surgical implantation of radiotelemetric transmitters is a current practice to collect variety physiological parameters in unrestrained laboratory animals, and rodents particular. In this study, the incidence peritoneal sarcomatosis arising secondary surgically implanted telemetry devices (< 15% Sprague Dawley rats) considered represent significant issue for both animal welfare data validity affected animals. Macroscopically, telemetry-associated fibrosarcomas spread along visceral parietal...
The goal of the study was to evaluate alternative student-centered approaches that could replace autopsy sessions and live demonstration explore refinements in assessment procedures for standardized cardiac dissection. Simulators videos were identified as feasible, economical, teaching methods technical skills training medical contexts, a direct comparison undertaken. A low-fidelity anatomically correct simulator approximately size horse's heart with embedded dissection pathways constructed...