Mitochondrial sn-glycerol 3-phosphate dehydrogenase (mGPDH) is a ubiquinone-linked enzyme in the mitochondrial inner membrane best characterized as part of glycerol phosphate shuttle that transfers reducing equivalents from cytosolic NADH into electron transport chain. Despite widespread expression mGPDH and availability mGPDH-null mice, physiological role this remains poorly defined many tissues, likely because compensatory pathways for regeneration NAD⁺ mechanisms metabolism. Here we...

Purpose To investigate the influence of vehicle operation speed, curve geometry parameters and rail profile on wheel–rail creepage in high-speed railway curves propose a multi-parameter coordinated optimization strategy to reduce contact fatigue damage. Design/methodology/approach Taking small-radius as research object, field measurements were conducted obtain track profiles. A coupled vehicle-track dynamics model was established. Multiple numerical experiments designed using Latin Hypercube...

<title>Abstract</title> The characteristic of endometriosis is that the endometrial tissue grows in non-endometrial parts such as pelvis and ovaries, leading to infertility chronic pain. However, its pathophysiology still unclear. Using high-precision single-cell RNA sequencing, we analyzed in-situ endometrium 13 individuals with or without endometriosis, including proliferative secretory phases. We have meticulously generated a comprehensive atlas eutopic from patients endometriosis....

Abstract The aqueous electrochemical CO 2 reduction to valuable products is seen as one of the most promising candidates achieve carbon neutrality yet still suffers from poor selectivity and lower current density. Highly efficient significantly relies on well‐constructed electrode realize stable triple‐phase contact , electrolyte, active sites. Herein, a interface engineering approach featuring combination hierarchical porous morphology design surface modification presented. A constructed by...

Rhizoctonia solani is one of the important pathogenic fungi causing several serious crop diseases, such as maize and rice sheath blight. Current methods used to control disease mainly depend on spraying fungicides because there no immunity or high resistance available in crops. Spraying double-strand RNA (dsRNA) for induced-gene silencing (SIGS) a new potentially sustainable environmentally friendly tool plant diseases. Here, we found that fluorescein-labelled EGFP-dsRNA could be absorbed by...

β2‐Glycoprotein I (β2GPI) is a principal target antigen for antiphospholipid antibodies associated with recurrent pregnancy loss and fetal growth restriction in women. The significance of disrupted β2GPI activity contributing to pathology syndrome (APS) not clear. In this study the physiological requirement functional was investigated by evaluating reproductive outcomes null mutant (β2GPI–/–) mice. β2GPI–/– mice were fertile carried viable fetuses term. However, there an 18% reduction number...

Considering the problem that least squares support vector machine prediction model with single kernel function cannot significantly improve accuracy of chaotic time series, a combination is proposed. The uses polynomial and radial basis to construct machine. An improved genetic algorithm better convergence speed precision proposed for parameter optimization model. simulation experimental results Lorenz, Mackey-Glass, Sunspot-Runoff in Yellow River network traffic series demonstrate...

We predict and realize the targeted wavelength conversion from 1550-nm band of a fs Er:fiber laser to an isolated inside 370-850 nm, corresponding blue-shift 700-1180 nm. The utilizes resonant dispersive wave generation in widely available optical fibers with good efficiency (~7%). converted has large pulse energy (~1 nJ), high spectral brightness mW/nm), broad Gaussian-like spectrum compressible clean transform-limited ~17 pulses. coherent fiber sources open up portable applications...

Coal spontaneous combustion disasters frequently appear in the process of coal mining, which brings great-hidden danger to mine safety production. To effectively inhibit combustion, HPMC/PEG/CS thermosensitive hydrogels with quick phase-transition response times and excellent thermal stability have been developed this study. Then, effects hydrogel on microscopic groups molecules at corresponding temperature heating processes are analyzed by using Fourier transform infrared spectrometry,...

Bioprinting is an emerging technology for tissue engineering and regenerative medicine. Despite its fast, accurate manufacture tissues organs in vitro, bioprinting has been seriously limited biofabrication because of the restricted approaches to reproducing extracellular matrix (ECM) with sufficient bioactivities bioprinted cells. Exosomes are natural biological particles proteins, lipids, or genetic materials. They have distinct properties unique functions manipulate cellular behaviors cell...

Abstract Background Wnt/β-catenin-mediated gene transcription plays important roles in a wide range of biological and pathophysiological processes including tumorigenesis where β-catenin-mediated activity frequently elevates. TRABID, deubiquitinase, was shown to have positive hence holds promise as putative anti-cancer target. Results In this study, we used combination structure based virtual screening an vitro deubiquitinase (DUB) assay identify several small molecules that inhibit TRABID...

Thermosensitive hydrogels have been receiving attention in the development of fire extinguishing agents due to their stimuli responsivity. Conventional are limited by slow response rate, and wettability has not studied systematically. In present study, a concentrate thermosensitive porous system successfully synthesized adding Na2CO3/CH3COOH as foaming agent into mixture hydroxypropyl methylcellulose (HPMC)/polyethylene glycol (PEG)/chitosan (CS). The systems with different concentrations...

Along with the development of beam-space multiplexing theory, multi-layer beamforming has been applied successfully in 4G and 5G terrestrial wireless communication systems to increase system capacity. For future Integrated Terrestrial-Satellite Communication (ITSC), is also expected improve gain, link quality, data transmission rate. This article explores ITSC toward B5G 6G, including its application scenarios, evolution trends, technical challenges key technologies. Based on analysis...