A5084296021- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Maternal and fetal healthcare
- Nausea and vomiting management
- Anesthesia and Neurotoxicity Research
- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Spine and Intervertebral Disc Pathology
- Cardiovascular Issues in Pregnancy
- Anesthesia and Sedative Agents
- Pain Management and Opioid Use
- Pregnancy-related medical research
- Birth, Development, and Health
- Preterm Birth and Chorioamnionitis
- Maternal and Perinatal Health Interventions
- Pediatric Pain Management Techniques
- Neuropeptides and Animal Physiology
- Venous Thromboembolism Diagnosis and Management
- Regulation of Appetite and Obesity
- Receptor Mechanisms and Signaling
- Blood Coagulation and Thrombosis Mechanisms
- Hemodynamic Monitoring and Therapy
- Cancer, Stress, Anesthesia, and Immune Response
- Airway Management and Intubation Techniques
- Biochemical Analysis and Sensing Techniques
Columbia University
2015-2025
Emory University
2023
University of Pittsburgh
2023
Columbia University Irving Medical Center
2007-2021
Presbyterian Hospital
2021
New York Proton Center
2020
Taranaki Base Hospital
2017-2019
Kaiser Permanente Riverside Medical Center
2016-2019
Baylor College of Medicine
2016-2019
Texas Children's Hospital
2019
Cesarean delivery rates continue to increase, and surgery is associated with chronic pain, often co-existing depression. Also, acute pain in the days after a strong predictor of pain. Here we tested if mode or played role persistent depression childbirth. In this multicenter, prospective, longitudinal cohort study, 1288 women hospitalized for cesarean vaginal were enrolled. Data obtained from patient interviews medical record review within 36 h postpartum, then via telephone 8 weeks later...
Because of the lack large obstetric anesthesia databases, incidences serious complications related to remain unknown. The Society for Obstetric Anesthesia and Perinatology developed Serious Complication Repository Project establish incidence identify risk factors associated with each.Serious were defined by Research Committee which also coordinated study. Thirty institutions participated in approximately 5-yr study period. Data collected as part institutional quality assurance sent central...
Labor initiates one of the most intensely painful episodes in a woman's life. Opioids are used to provide analgesia with substantial interindividual variability efficacy. mu-Opioid receptor (muOR, OPRM1) genetic variants may explain differences response opioid analgesia. We hypothesized that OPRM1 304A/G polymorphism influences median effective dose (ED(50)) intrathecal fentanyl via combined spinal-epidural for labor Nulliparous women were prospectively recruited around 35 weeks gestation...
Chronic pain after surgery occurs in 10-40% of individuals, including 5-20% women cesarean delivery previous reports. Pain and depression 2 months childbirth are independently associated with more severe acute post-delivery pain. Here we examine other predictors at determine the incidence 6 12 childbirth.
Neuraxial analgesia is chosen by almost half of women who give birth in the United States. Unintentional dural puncture most common complication this pain management technique, occurring 0.4% to 6% parturients. Severe positional headaches develop acutely 70% 80% these Acute postdural are well known, but few studies have investigated long-term sequelae. We incidence and risk factors for chronic headache back parturients experienced unintentional with a 17-gauge Tuohy needle compared matched...
To identify whether pregnancy outcomes vary by etiology and severity of pulmonary hypertension contemporary therapies influence outcomes.A retrospective review medical records at four academic institutions was conducted to pregnant women with (2001-2015). International Classification Diseases, 9th Revision codes for were used potential participants. Medical abstracted demographics, management, outcomes. Women classified according the 2013 World Health Organization (WHO) classification groups...
Obstetric venous thromboembolism is a leading cause of severe maternal morbidity and mortality. Maternal death from amenable to prevention, thromboprophylaxis the most readily implementable means systematically reducing rate. Observational data support benefit risk-factor-based prophylaxis in obstetric thromboembolism. This bundle, developed by multidisciplinary working group published National Partnership for Safety under guidance Council on Patient Women's Health Care, supports routine...
The β3-adrenoceptor is a G protein-coupled receptor which mediates metabolic functions of the endogenous catecholamines epinephrine and norepinephrine. Questions exist regarding distribution in human tissue. In order to examine mRNA tissues, we used sensitive specific RNase protection assays without previous PCR amplification an extensive list tissues. We confirm presence white fat from several locations, gall bladder, small intestine, as well extend previously uncharacterized tissues such...
Abstract Background Current recommendations for women undergoing cesarean delivery include 15° left tilt uterine displacement to prevent aortocaval compression, although this degree of is practically never achieved. We hypothesized that under contemporary clinical practice, including a crystalloid coload and phenylephrine infusion targeted at maintaining baseline systolic blood pressure, there would be no effect maternal position on neonatal acid base status in elective with spinal...
There are marked interethnic differences in β1-adrenoceptor-mediated responsiveness, with sensitivity decreased African-Americans and increased Chinese compared Caucasians. Therefore, the frequency of a common naturally occurring polymorphism human β1-adrenoceptor gene (Arg389Gly), which has functional importance vitro, was determined 194 African-Americans, 316 Caucasian-Americans, 221 Hispanic-Americans 142 Chinese. were found to have significantly lower Arg389 allele than other three...
Identification of risk factors for adverse obstetrical outcomes after appendectomy and cholecystectomy during pregnancy is necessary evidence-based reduction adequate patient counseling.
In order to examine the clinical potential of desflurane (difluoromethyl-1-fluoro-2,2,2-trifluoroethyl ether) in humans, a randomized, controlled study was designed compare time emergence from anesthesia patients undergoing elective surgery under that isoflurane anesthesia. Twenty-eight were randomly divided into four groups. Group 1 received 0.65 MAC; group 2, 3, 1.25 and 4, MAC. Anesthesia induced with sodium thiopental, N2O 60% added volatile agent. Mean anesthetic exposure times (min...
(Abstracted from Anesth Analg, 123(4):942–949, 2016) According to the World Health Organization, 14.9% of maternal deaths in developed nations such as those Europe and North America, Australia, New Zealand, Japan are thought involve embolism. In United States alone, per Centers for Disease Control Prevention (2006–2010), approximately 9.3% pregnancy-related a result thrombotic pulmonary
Maternal hypotension is common after spinal anesthesia for cesarean delivery. There wide variability in the incidence and severity of response to treatment. The beta2 adrenoceptor (beta2AR) possesses several polymorphic sites. Codons 16 (Arg16Gly) 27 (Glu27Gln) have been shown affect desensitization receptor. goal this study was determine whether genetic variants beta2AR alter or amount vasopressor treatment required during delivery.One hundred seventy healthy women undergoing elective...
Subjects maintaining a ≥10% dietary weight loss exhibit decreased circulating concentrations of bioactive thyroid hormones and increased skeletal muscle work efficiency largely due to expression more-efficient myosin heavy chain (MHC) isoforms (MHC I) significantly mediated by the adipocyte-derived hormone leptin. The primary purpose this study was examine effects triiodothyronine (T3) repletion on energy homeostasis physiology in weight-reduced subjects compare these results with leptin...