A5014048581- Helicobacter pylori-related gastroenterology studies
- Marine Sponges and Natural Products
- Bacteriophages and microbial interactions
- Salmonella and Campylobacter epidemiology
- Aquaculture disease management and microbiota
- Antimicrobial Resistance in Staphylococcus
- Vibrio bacteria research studies
- Viral gastroenteritis research and epidemiology
- Galectins and Cancer Biology
- Antibiotic Resistance in Bacteria
- Eosinophilic Esophagitis
- Veterinary medicine and infectious diseases
- Bacterial biofilms and quorum sensing
- Escherichia coli research studies
- Genetics and Plant Breeding
- Genetic and Environmental Crop Studies
- Mosquito-borne diseases and control
- Malaria Research and Control
- Synthesis and Biological Activity
- Gastroesophageal reflux and treatments
- Microbial Natural Products and Biosynthesis
- Phytochemistry and Bioactivity Studies
- Traditional and Medicinal Uses of Annonaceae
- Viral Infections and Outbreaks Research
- Bacterial Identification and Susceptibility Testing
Agricultural Research Council of South Africa
2020-2025
University of Fort Hare
2017-2021
Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria
2021
University of Buea
2013-2015
Background: Resistance of Staphylococcus aureus to commonly used antibiotics is linked their ability acquire and disseminate antimicrobial-resistant determinants in nature, the marine environment may serve as a reservoir for antibiotic-resistant bacteria. This study determined antibiotic sensitivity profile S. isolated from selected beach water intertidal sand Eastern Cape Province South Africa. Methods: Two hundred forty-nine samples were obtained 10 beaches April 2015 2016. was using...
The global prevalence of H. pylori approaches 50%, with rates between 20 and 40% in developed countries up to 90% Africa other developing nations the world. Development pylori-associated diseases is determined by a number virulence factors. This study aimed at determining infections genes (cagA, dupA, vacA); relationship factors gastroduodenal among patients.Gastric biopsies were obtained from patients cultured, DNA was extracted cultured isolates for PCR assay after which samples...
Haematologic abnormalities are features in Plasmodium falciparum infection, and anaemia is an inevitable outcome. This study examines the influence of malaria status altitude on haematologic parameters school-aged pupils.A cross-sectional was conducted among 728 school pupils aged between four 15 years at three different altitudinal ranges along slope Mount Cameroon region. The investigative methods included use questionnaire, clinical evaluation laboratory investigations. Blood sample...
Antimicrobial‐resistant Escherichia coli , especially those belonging to the serotype O157, are increasingly linked foodborne diseases with significant fatality rates worldwide. The food and medical industries have focused on E. O157:H7 due its ability produce toxins coupled low infectious dose. aim of this study was assess virulome, resistome, pathogenicity using whole genome sequencing. Three previously isolated strains from cattle feces were subjected sizes all three 5,117,276 bp,...
Cholera has been endemic in Douala, since 1971 when it was first recorded Cameroon. Outbreaks have often started slum areas of the city including New Bell. Despite devastating nature outbreaks, always resulting high mortality and morbidity, a paucity information exists on reservoirs causative agent, V. cholerae, factors maintaining its persistence. This complicated disease prevention, frequent outbreaks cholera. We investigated water sources Bell for contamination with cholerae O1 pathogenic...
Thirty-three (33) isolates of methicillin-resistant Staphylococcus aureus (MRSA) from healthy edible marine fish harvested two aquaculture settings and the Kariega estuary, South Africa, were characterised in this study. The phenotypic antimicrobial susceptibility profiles to 13 antibiotics determined, their antibiotic resistance determinants assessed. A multiplex PCR was used determine epidemiological groups based on type SCC mec carriage followed by detection staphylococcal...
Abstract Helicobacter pylori is a gram-negative, spiral-shaped bacterial pathogen and the causative agent for gastritis, peptic ulcer disease classified as WHO class I carcinogen. While prevalence of H. infections in Africa among highest world, incidence gastric cancer comparably low. Little known about other symptoms related to infection association with certain phenotypes virulence. We established network study sites Nigeria (NG) South (ZA) gain an overview on epidemiological situation. In...
Campylobacter jejuni (CJ) is a zoonotic microbe and major causative organism of diarrheal infection in humans that often has its functional characteristics inactivated stressed conditions. The current study assessed the correlation between recovered CJ water quality parameters drug sensitivity patterns pathogen to frontline antibiotics human veterinary medicine. Water samples (n = 244) from rivers/estuarines were collected April–September 2016, physicochemical conditions recorded on-site....
This multicenter study was undertaken to determine the prevalence of Helicobacter pylori (H. pylori) infection among dyspeptic patients with and without type 2 diabetes mellitus (T2DM).Patients dyspepsia were recruited from tertiary teaching hospitals, three in South-West one South-South regions Nigeria, between November 2016 August 2017. The participants had breath samples analyzed for H. by Urea Breath Test (UBT) following manufacturer's instructions. Dyspeptic who diagnosed previously...
Background: Seafood-borne Vibrio infections, often linked to contaminated seafood and water, are of increasing global public health concern. The aim this study was evaluate the prevalence human pathogenic vibrios their associated virulence genes isolated from fish water samples 2 commercial dusky kob farms Kareiga estuary, South Africa. Methods: A total 200 including (n = 120) seawater 80) were subjected screening on thiosulfate-citrate-bile salts-sucrose agar (TCBS). Presumptive isolates...
Abstract The increase in multi drug resistance (MDR) amongst food-borne pathogens such as Escherichia coli O157:H7, coupled with the upsurge of infections caused by these is a major public health concern. Lytic phages have been employed an alternative to antibiotics for use against pathogens. However, effective application, should be selectively toxic. Therefore, objective this study was characterise lytic E. O157:H7 isolated from wastewater possible biocontrol agents and access their...
Abstract This study was conducted to ascertain the occurrence of methicillin‐resistant Staphylococcus aureus (MRSA) in marine finfish ( Argyrosomus japonicus ) harvested from wild and two re‐circulatory aquaculture systems, evaluating reliability three phenotypic methods detection methicillin resistance. A total 120 dusky kob fish were sampled for S. using conventional confirmed by polymerase chain reaction (PCR) targeting nuc gene. Methicillin resistance determined molecular mecA Using as...
This study aimed to evaluate the antibiogram and antibiotic resistance genes (ARGs) of Vibrio isolates recovered from a marine fish (Argyrosomus japonicus) water samples two commercial dusky kob aquaculture farms Kariega estuary, South Africa, these findings for their public health implications. A total 277 molecularly confirmed consisting 126 fluvialis, 45 vulnificus, 30 Parahaemolyticus, 76 vibrios belonging species genus other than cholerae were subjected susceptibility testing 15...
Introduction Helicobacter pylori is a spiral shaped gram negative bacterium majorly causing peptic ulcers and gastric cancer in humans. The combinations of two or more antibiotics such as amoxicillin, clarithromycin, metronidazole tetracycline with anti-secretory agents bismuth have been used successfully for the treatment H. . Aim Increasing antibiotic resistance has contributory factor to failures; evaluation mechanism will improve management infection. Methodology isolates from Nigeria...
Helicobacter pylori is a principal cause of gastric cancer. The aim this study was to determine the prevalence and contribution duodenal ulcer promoting gene A (dupA), plasticity region genes sigma factors in relation their pathological expression H. infections Nigerian population.Polymerase Chain Reaction used analyze total forty-nine strains isolated from patients attending various endoscopic units tertiary hospitals Nigeria for complete dupA (G27 variant), jhp0917, jhp0918, other jhp...
Northern corn leaf blight (NCLB) caused by Exserohilum turcicum and Fusarium ear rot verticillioides, are economically important maize diseases in South Africa. The effect of induced plant stress NCLB on F. verticillioides fumonisin production is unknown. Four field trials were conducted during 2016/2017 2017/2018 (November December planting dates) at the Agricultural Research Council – Grain Crops Potchefstroom (South Africa). Three cultivars with varying resistance levels to selected...
Marine invertebrates constitute a diverse group of marine organisms beneficial to humanity due their therapeutic significance. The sponge species Psammaplysilla sp. 1 was collected from Philips Reef, South Africa, over four-season period and assayed for antimicrobial potential. physicochemical parameters the collection site were also recorded. crude extracts’ activity evaluated using an agar well diffusion assay against 5 pathogens. Phytochemical screening conducted identify presence 7...
Abstract Marine invertebrates constitute a diverse group of marine organisms beneficial to humankind due their therapeutic significance. The sponge species Psammaplysilla sp. 1 was collected from Philips Reef, South Africa, over four-season period and assayed for antimicrobial potential. physicochemical parameters the collection site were also recorded. crude extracts' activity evaluated using an agar well diffusion assay against five pathogens. Phytochemical screening conducted identify...
Scientists have continuously searched for novel bioactive compounds to overcome the inherent problems associated with drug resistance, evolution of unknown diseases, and toxicity currently used compounds. The ocean has been considered a rich source that possess unique chemical structures biological capabilities. Biologically active molecules isolated from marine flora fauna shown significant advancement over past century in pharmaceutical industry. Marine natural products (MNPs) as...