A5101785350- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- Cancer, Lipids, and Metabolism
- Folate and B Vitamins Research
- Diet, Metabolism, and Disease
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Immune cells in cancer
- Gallbladder and Bile Duct Disorders
Heidelberg University
2019-2021
Ajou University
2021
City of Hope
2011
Beckman Research Institute
2011
Nonalcoholic fatty liver disease (NAFLD) includes various hepatic pathologies ranging from steatosis to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Estrogen provides a protective effect on the development of NAFLD in women. Therefore, postmenopausal women have higher risk developing NAFLD. Hepatic is an early stage disease. Steatosis can develop aggressive stages (nonalcoholic steatohepatitis, cirrhosis). Currently, there no specific drug prevent/treat these diseases. In...
Drain fluid amylase is commonly used as a predictor of pancreatic fistula after pancreaticoduodenectomy (PD). This study aimed to determine the ideal cut-off value drain on postoperative day 1 (DFA1) for predicting pancreaticogastrostomy (PG).Prospective data 272 consecutive patients undergoing PG between 2010 and 2020 was collected analysed (POPF) risk factors.The incidence POPF 143 cases (52.6%). The median DFA1 in with significantly higher than that NO-POPF (5483 versus 311, P < 0.001)....
Objective: To explore the influence of patatin-like phospholipase domain containing-3 (PNPLA3) wild type 148I/I and mutant 148M/M on HepG2 cell proliferation relative mechanisms. Methods: line stably overexpressing PNPLA3 148I/I, negative control (NC) were set up. Cell counting kit-8 (CCK8) assay was used to measure viability. Edu determine ability proliferation. Western blot detect protein levels in phosphatidylinositol 3-kinases (PI3K) pathway. Enzyme-linked immunosorbent (ELISA)...
Background Nonalcoholic fatty liver disease (NAFLD), comprising a sequence of steatosis, non-alcoholic steatohepatitis (NASH), and fibrosis, significantly increases surgical morbidity in patients undergoing resection. Improving function NAFLD is therefore particular importance. We previously demonstrated that the prolyl hydroxylase (PHD) small-molecule inhibitor ethyl-3,4-dihydroxybenzoate (EDHB) promotes regeneration, putatively via organic anion transporting polypeptide 1B1 (OATP1B1)....