A5100778966- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Radiomics and Machine Learning in Medical Imaging
- Neural dynamics and brain function
- Liver Disease Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Electrochemical Analysis and Applications
- Hepatitis C virus research
- Trauma Management and Diagnosis
- Shoulder and Clavicle Injuries
- Bone fractures and treatments
- Conducting polymers and applications
- Blood transfusion and management
- Nephrotoxicity and Medicinal Plants
- Machine Learning in Materials Science
- Clostridium difficile and Clostridium perfringens research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Colorectal Cancer Surgical Treatments
- Advanced Memory and Neural Computing
- Scoliosis diagnosis and treatment
- Lung Cancer Research Studies
- Pelvic and Acetabular Injuries
- Nursing Diagnosis and Documentation
- Diet, Metabolism, and Disease
- Fault Detection and Control Systems
Duke University
2015-2024
New York University
2016-2024
New York University Langone Orthopedic Hospital
2021
NorthShore University HealthSystem
2019
SUNY Polytechnic Institute
2016
Office of Infectious Diseases
2015
Yale University
2014
Brown University
2013
Rhode Island Hospital
2013
Beckman Research Institute
2011
Patients suffering from debilitating neurodegenerative diseases often lose the ability to communicate, detrimentally affecting their quality of life. One solution restore communication is decode signals directly brain enable neural speech prostheses. However, decoding has been limited by coarse recordings which inadequately capture rich spatio-temporal structure human signals. To resolve this limitation, we performed high-resolution, micro-electrocorticographic (µECoG) during intra-operative...
Objectives. We evaluated the safety of room occupants in Tuberculosis Ultraviolet Shelter Study (TUSS), a double-blind, placebo-controlled field trial upper-room ultraviolet germicidal irradiation (UVGI) at 14 homeless shelters six U.S. cities from 1997 to 2004. Methods. Data collection involved administering questionnaires regarding eye and skin irritation total 3,611 staff study subjects. Results. Among these subjects, there were 223 reports or symptoms. During active UV period, 95 (6%)...
The clinical use of microsignals recorded over broad cortical regions is largely limited by the chronic reliability implanted interfaces.
Abstract Objective Effective surgical treatment of drug‐resistant epilepsy depends on accurate localization the epileptogenic zone (EZ). High‐frequency oscillations (HFOs) are potential biomarkers EZ. Previous research has shown that HFOs often occur within submillimeter areas brain tissue and coarse spatial sampling clinical intracranial electrode arrays may limit capture HFO activity. In this study, we sought to characterize microscale activity captured thin, flexible...
Objective. Micro-electrocorticography (μECoG) offers a minimally invasive neural interface with high spatial resolution over large areas of cortex. However, electrode arrays many contacts that are individually wired to external recording systems cumbersome and make recordings in freely behaving rodents challenging. We report novel high-density 60-electrode system for μECoG moving rats. Approach. Multiplexed headstages overcome the problem wiring complexity by combining signals from...
One-third of epilepsy patients suffer from medication-resistant seizures. While surgery to remove epileptogenic tissue helps some patients, 30-70% continue experience seizures following resection. Surgical outcomes may be improved with more accurate localization tissue. We have previously developed novel thin-film, subdural electrode arrays hundreds microelectrodes over a 100-1000 mm2 area enable high-resolution mapping neural activity. Here, we used these high-density study microscale...
Nonalcoholic fatty liver disease (NAFLD) includes various hepatic pathologies ranging from steatosis to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Estrogen provides a protective effect on the development of NAFLD in women. Therefore, postmenopausal women have higher risk developing NAFLD. Hepatic is an early stage disease. Steatosis can develop aggressive stages (nonalcoholic steatohepatitis, cirrhosis). Currently, there no specific drug prevent/treat these diseases. In...
Abstract Spreading depolarizations (SDs) are widely recognized as a major contributor to the progression of tissue damage from ischemic stroke even if blood flow can be restored. They characterized by negative intracortical waveforms up -20 mV, propagation velocities 3 - 6 mm/min, and massive disturbance membrane ion homeostasis. High-density, micro-electrocorticographic (μECoG) epidural electrodes custom, DC-coupled, multiplexed amplifiers, were used continuously characterize monitor SD...
A 52-year-old male presented with signs of acute hepatitis and liver failure. Laboratory investigations for common etiologies were unrevealing, but history suggested injury secondary to ingestion a traditional South African herbal tea made rooibos buchu. Livery biopsy confirmed toxin-mediated injury. The patient recovered function after stopping the tea. Although hepatotoxicity associated buchu has rarely been reported, anecdotal correspondence physicians suspected cases. Hepatotoxicity may...
Simultaneous interrogation of electrical signals from wide areas the brain is vital for neuroscience research and can aid in understanding mechanisms function treatments neurological disorders. There emerges a demand development devices with highly conformal interfaces that span large cortical regions, have sufficient spatial resolution, chronic recording capability while keeping small implantation footprint. In this work, we designed 61 channel 48 high-density, cortical,...
HIV and hepatitis C (HCV) co-infection is highly common among Chinese injection drug users but it difficult to reach IDUs at traditional VCT (Voluntary counseling treatment) clinics. A new national model integrating HIV/HCV testing with methadone maintenance treatment was started in 2006. The purpose of this study investigate HCV test uptake associated factors clinics Guangdong Province, China.A cross-sectional design using routine surveillance data laboratory confirmation applied determine...
Study Design. Retrospective review. Objective. Identify co-occurring perioperative complications and associated predictors in a population of patients undergoing surgery for adult spinal deformity (ASD). Summary Background Data. Few studies have investigated the development multiple, following ASD-corrective surgery. Preoperative risk stratification may benefit from identification factors with complications. Methods. Elective ASD National Surgical Quality Improvement Program (NSQIP) 2005 to...
Micro-Electrocorticography (μECoG) offers a minimally invasive, high resolution interface with large areas of cortex. A wide variety μECoG designs have been developed and customized [1]-[4], including active, multiplexed arrays [5] on dissolving substrates for increased conformal contact [6]. However, designing fabricating requires access to microfabrication facilities, which many neuroscience labs do not have. Microfabrication is also typically labor intensive expensive. Commercial 64...
The Affordable Care Act emphasizes the use of quality metrics and greater patient understanding health-care options access to physician performance data. objectives this study were determine patients' familiarity with colonoscopy measures (CQMs) their influence on selection a colonoscopist.A prospective survey patients before screening or surveillance at university hospital, community ambulatory procedure center endoscopy units was performed from 2011 2012.Among 417 participants, 20%...
» The induced membrane technique (IMT) takes advantage of an osteoinductive environment that is created by the placement a cement spacer into bone defect. Most commonly, polymethylmethacrylate (PMMA) has been used, but spacers made from other materials have emerged and achieved good clinical outcomes. IMT demonstrated results for long-bone repair; however, more research required in order to optimize union rates as well delineate precise indications surgical timing.
Abstract The neural basis of speech production involves the rapid transition from abstract planning units such as syllables and phonemes, to motor execution sounds. Although a distributed network brain regions has been implicated in overall, it is unclear how transitions for production. Leveraging high spatio-temporal resolution intracranial recordings, we find evidence mechanisms that operate space time across prefrontal premotor cortices facilitate execution. During this execution, show...
Objective: To use the electronic medical record (EMR) to optimize patient care, facilitate documentation, and support quality improvement practice-based research in a concussion (mild traumatic brain injury; mTBI) clinic.Methods: We built customized structured clinical documentation (SCDS) toolkit for patients specialty clinic. The collected hundreds of fields discrete, standardized data. Autoscored interpreted score tests include Generalized Anxiety Disorder 7-item scale, Center...
Tranexamic acid (TXA) is a drug used to control hemorrhage by preventing the breakdown of fibrin.TXA cost-effective treatment for trauma patients across variety economic settings.Concerns TXA causing thromboembolic events (TEEs) in orthopaedic are not supported evidence.TXA has been shown reduce blood loss hip fracture surgery.
Abstract One-third of epilepsy patients suffer from medication-resistant seizures. While surgery to remove epileptogenic tissue helps some patients, 30–70% continue experience seizures following resection. Surgical outcomes may be improved with more accurate localization tissue. We have previously developed novel thin-film, subdural electrode arrays hundreds microelectrodes over a 100–1,000 mm 2 area enable high-resolution mapping neural activity. Here we used these high-density study...