Abstract Behavioural engagement can enhance sensory perception. However, the neuronal mechanisms by which behavioural states affect stimulus perception remain poorly understood. Here we record from single units in auditory cortex of rats performing a self-initiated go/no-go task. Self-initiation transforms cortical tuning curves and bidirectionally modulates stimulus-evoked activity patterns improves detection recognition. Trial self-initiation decreases rate spontaneous majority recorded...

Simple tonal stimuli can shape spectral tuning of cortical neurons during an early epoch brain development. The effects complex sound experience on development remain to be determined. We exposed rat pups a frequency-modulated (FM) sweep in different time windows development, and examined the such sensory representations primary auditory cortex (AI). found that exposure FM resulted altered characteristic frequency broadened AI neurons, whereas later same only led greater selectivity for rate...

Neurons recorded in behaving animals often do not discernibly respond to sensory input and are overtly task-modulated. These non-classically responsive neurons difficult interpret typically neglected from analysis, confounding attempts connect neural activity perception behavior. Here, we describe a trial-by-trial, spike-timing-based algorithm reveal the coding capacities of these auditory frontal cortex rats. Classically cells contained significant information about stimuli behavioral...

The clinical use of microsignals recorded over broad cortical regions is largely limited by the chronic reliability implanted interfaces.

Abstract Neuronal responses during behavior are diverse, ranging from highly reliable ‘classical’ to irregular ‘non-classically responsive’ firing. While a continuum of response properties is observed across neural systems, little known about the synaptic origins and contributions diverse network function, perception, behavior. To capture heterogeneous measured auditory cortex rodents performing frequency recognition task, we use novel task-performing spiking recurrent incorporating...

Objective. Micro-electrocorticography (μECoG) offers a minimally invasive neural interface with high spatial resolution over large areas of cortex. However, electrode arrays many contacts that are individually wired to external recording systems cumbersome and make recordings in freely behaving rodents challenging. We report novel high-density 60-electrode system for μECoG moving rats. Approach. Multiplexed headstages overcome the problem wiring complexity by combining signals from...

Cortical sound representations are adapted to the acoustic environment. Early exposure exponential frequency-modulated (FM) sweeps results in more neurons selective experienced sounds. Here we examined influence of pulsed noise experience on development primary auditory cortex (AI) rat. In naïve animals, FM sweep direction selectivity depends characteristic frequency (CF) neuron--low CF tend select for upward and high downward sweeps. Such a dependence was not observed animals that had...

Objective. High channel count electrode arrays allow for the monitoring of large-scale neural activity at high spatial resolution. Implantable featuring many recording sites require compact, bandwidth front-end electronics. In present study, we investigated use a small, light weight, and low cost digital current-sensing integrated circuit acquiring cortical surface signals from 61-channel micro-electrocorticographic (μECoG) array. Approach. We recorded both acute chronic μECoG signal rat...

Micro-Electrocorticography (μECoG) offers a minimally invasive, high resolution interface with large areas of cortex. A wide variety μECoG designs have been developed and customized [1]-[4], including active, multiplexed arrays [5] on dissolving substrates for increased conformal contact [6]. However, designing fabricating requires access to microfabrication facilities, which many neuroscience labs do not have. Microfabrication is also typically labor intensive expensive. Commercial 64...

Micro-Electrocorticography (μECoG) offers a minimally invasive, high resolution interface with large areas of cortex. However, arrays electrodes many contacts that are individually wired to external recording systems cumbersome and make chronic in freely behaving small animals challenging. Multiplexed headstages overcome this limitation by combining the signals from smaller number connections directly on animal's head. Commercially available multiplexed provide performance integrated...

Objectives. Although hippocampal neurogenesis has been implicated in mood disorders, the precise role new neurons play regulation is not fully elucidated. Here we examine whether improves by facilitating segregation of novel experiences that conflict with older maladaptive memories. Methods. Study 1: Four groups (N = 9 each) adult male rats (exposed to stress or control conditions plus antidepressant placebo) underwent active training on place-avoidance task (PAT) week 0; tested recalling...

Neurons recorded in behaving animals often do not discernibly respond to sensory input and are overtly task-modulated. These nominally non-responsive neurons difficult interpret typically neglected from analysis, confounding attempts connect neural activity perception behavior. Here we describe a trial-by-trial, spike-timing-based algorithm reveal the hidden coding capacities of these auditory frontal cortex rats. Responsive cells contained significant information about stimuli behavioral...

The ability to flexibly respond sensory cues in dynamic environments is essential adaptive auditory-guided behaviors. Cortical spiking responses during behavior are highly diverse, ranging from reliable trial-averaged seemingly random firing patterns. While the of 'classically responsive' cells have been extensively studied for decades, contribution irregular 'non-classically has remained underexplored despite their prevalence. Here, we show that flexible auditory results interactions...

Abstract Neuronal responses during behavior are diverse, ranging from highly reliable ‘classical’ to irregular or seemingly-random ‘non-classically responsive’ firing. While a continuum of response properties is frequently observed across neural systems, little known about the synaptic origins and contributions diverse profiles network function, perception, behavior. Here we use task-performing, spiking recurrent model incorporating spike-timing-dependent plasticity that captures...

<title>Abstract</title> Neuronal responses during behavior are diverse, ranging from highly reliable ‘classical’ to irregular or seemingly-random ‘non-classically responsive’ firing. While a continuum of response properties is frequently observed across neural systems, little known about the synaptic origins and contributions diverse profiles network function, perception, behavior. Here we use task-performing, spiking recurrent model incorporating spike-timing-dependent plasticity that...