A5101858449- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Chronic Lymphocytic Leukemia Research
- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Blood disorders and treatments
- Eosinophilic Disorders and Syndromes
- Acute Lymphoblastic Leukemia research
- Pregnancy and preeclampsia studies
- Hemophilia Treatment and Research
- Cardiovascular Issues in Pregnancy
- Atrial Fibrillation Management and Outcomes
- Emergency and Acute Care Studies
- Pneumonia and Respiratory Infections
- Acute Ischemic Stroke Management
- Protein Degradation and Inhibitors
- Iron Metabolism and Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Respiratory viral infections research
- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neutropenia and Cancer Infections
- Polyomavirus and related diseases
- Hematopoietic Stem Cell Transplantation
Universidad de Antioquia
2007-2023
Hospital Universitario de San Vicente Fundación
2004-2023
ORCID
2021
Hospital Lluis Alcanyis
2008
Thrombosis Research Institute
2004
Studies have shown an association between recurrent pregnancy loss and inherited thrombophilia in Caucasian populations, but there is insufficient knowledge concerning triethnic populations such as the Colombian. The aim of this study was to evaluate whether associated with loss. Methods . We conducted a case-control 93 patients (cases) 206 healthy multiparous women (controls) Colombian subpopulation. Three single nucleotide polymorphisms (SNPs) markers thrombophilias factor V Leiden,...
Abstract The development of venous thromboembolism is influenced by a variety genetic and environmental risk factors. A few studies have ascertained whether thrombophilic defects are factors for in Latin American populations with variable degree admixture, such as the Colombian population. To address this issue, we conducted case–control study involving 100 consecutive patients deep vein thrombosis 114 healthy controls from Hospital Universitario San Vicente de Paúl, Medellín, Colombia....
To evaluate the aspirin resistance prevalence in patients with previous ischemic cerebrovascular disease undergoing therapy for secondary prevention.Three hundred fifty presenting strokes and 100 healthy controls under treatment were evaluated using optic platelet aggregation test.Aspirin was found 7.4% of stroke 4% controls. Aspirin associated recurrence univariate analysis (p = 0.004). not smoking, diabetes, or hypercholesterolemia.Aspirin is present Colombian as well
Introducción: la leucemia mieloide crónica (LMC) se caracteriza por presencia del cromosoma Filadelfia (Ph) que resulta de translocación recíproca balanceada t(9;22)(q34;q11); este marcador cromosómico encuentra con menor frecuencia en pacientes linfoide aguda (LLA).Objetivo: determinar las fusiones génicas BCR-ABL, codifican para los transcriptos p210BCR-ABL y p190 BCR-ABL colombianos diagnóstico LMC, diferentes fases enfermedad o su tratamiento.Materiales métodos: estudio descriptivo corte...
The 20210A allele of the prothrombin gene is associated with increased risk venous thromboembolism. In this study, we described manifestations thrombosis in four generations a Colombian family, homozygous carriers and six 20210G/A heterozygous for polymorphism as well unrelated participants from same population. levels homozygote patients were higher than normal 20210G homozygotes (133 + 11% 92.3 12.4%, respectively, P < .01) heterozygotes vs. 114.8 24%, .05). About 2 out 4 5 6 members...
BackgroundAmong the chronic myeloproliferative neoplasms (MPNs) not associated with BCR-ABL mutations are polycythemia vera, primary myelofibrosis, and essential thrombocythemia. These diseases caused by gene mutations, such as JAK2, MPL, CALR genes, which regulate JAK-STAT signaling pathway. ObjectiveThis study aimed to establish frequencies of in genes Colombian patients a negative clinical diagnosis neoplasms. MethodsThe JAK2 V617F MPL W515K deletions or insertions exon 9 were analyzed 52...
Es frecuente la presencia de pruebas compatibilidad positivas en pacientes que requieren soporte transfusional. Los con anemia hemolítica autoinmune presentan autoanticuerpos calientes o fríos reaccionan contra antígenos los eritrocitos y producen reacciones hemolíticas, pueden ir desde leves hasta graves. multitransfundidos insuficiencia renal crónica células falciformes, aloanticuerpos dificultan el tratamiento derivados sangre. La frecuencia mismos es 32% algunas series. Dado...
Introducción: la púrpura trombocitopénica trombótica (PTT) es una enfermedad infrecuente, que se caracteriza por anemia hemolítica no inmune, trombocitopenia y microangiopatía trombótica. En este estudio describen las características clínicas, de laboratorio el tratamiento serie pacientes con PTT comparando según presencia o ausencia asociada.
 Material métodos: observacional descriptivo diagnóstico en un centro referencia Medellín (Colombia), evaluados entre 2012 2021.
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La leucemia mieloide extramedular (LME), también conocida como sarcoma granulocítico, es una manifestación de la aguda. Puede presentarse virtualmente en todos los sitios del organismo y cualquier momento evolución enfermedad primaria. Se define lesión tumoral compuesta células mieloides inmaduras que se localiza sitio extramedular.Se reporta el caso paciente 39 años edad quien presentó con compromiso uterino simuló un carcinoma endometrial finalmente diagnosticó LME uterino, contexto aguda...
Una de las posibles causas la PGR es trombofilia, lacual se define como una tendencia a desarrollar trombosis convariabilidad en manifestaciones clínicas dependiente laregión vascular afectada por ausencia del flujo sanguíneo. Latrombosis enfermedad multifactorial, cualcontribuyen factores genéticos y ambientales al riesgo deldesarrollo (1). Las trombofilias heredadas están asociadas polimorfismos los genes factor V LeidenG1691A, protrombina G20210A ilentetrahidrofolatoreductasa(MTHFR)...
In recent years, umbilical cord blood (UCB) has emerged as a feasible alternative source of hematopoietic progenitors (CD34+) for allogeneic stem cell transplantation, mainly in patients who lack HLA-matched related marrow donors. Since the first unrelated donor transplant 1993 more than 3500 have received UCB transplants variety malignant and non-malignant diseases. At Hospital San Vicente de Paúl Medellı́n,Colombia, 12 patients, 10 children two adults been transplanted with since 2001. 8...
La leucemia promielocítica aguda (LPA) es un subtipo de mieloide (LMA) que se origina por una traslocación balanceada entre los cromosomas 15 y 17, involucra al gen codifica para el receptor alfa del ácido retinoico (RARA) en cromosoma 17 la (PML) 15, lo da origen a t(15;17) PML/RARA. Dicho reordenamiento proteína fusión PML/RAR alfa, bloquea diferenciación las células madre mieloides estadio promielocito. LPA afecta con mayor frecuencia adultos jóvenes conlleva alto riesgo mortalidad...